DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr81 and sel-2

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	NP_001379017.1	Gene:	sel-2 / 175606	WormBaseID:	WBGene00004760	Length:	2563	Species:	Caenorhabditis elegans

Alignment Length:	861	Identity:	177/861 - (20%)
Similarity:	290/861 - (33%)	Gaps:	286/861 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 LWEEAYRKYNGAHVRMCRSTPSAPSTKP-----PSGQGQLQPH-------DVVLKELIQRVYRCP 170
            :||:..|       |..|..|:|..::.     |.|:...:|.       ..|||.|..:.....
Worm  1667 VWEDDSR-------RRKRFVPNAYGSRHEEANLPEGEKNEEPEISEQEKIRKVLKGLFSKRQNSS 1724

  Fly   171 VLHCQLDRDGV---SDSSNATSCSAGSCHAN----VLPALVAIETSTHISVFFYPPALECSLYDC 228
            ..|..:|...:   :...:.|..|..:|.:.    :.|.:|.            |..|..:..|
Worm  1725 GSHELVDESDIDKWAQEVDPTPSSQSACFSTTAKLIAPGVVV------------PGTLSVTAND- 1776

  Fly   229 ITFSPALLGKNYNKTLFVIYQILQLAKHLQG-------QGLFLGDLRLQDIVLRENLWLQVLPRL 286
            :.|.......||.|.   ..|:|:..:.|..       :.:||....||:..|  .|:|.....:
Worm  1777 LFFDANESDPNYKKQ---CAQVLRYCEALHARWNLQEIRAIFLRRYLLQNTAL--ELFLASRTAI 1836

  Fly   287 QCNLLDDDPAGEDMSPLTPL---VSEDLGEAREAQQALPSSSTMFDLRFAYDPAHFNLREYTEM- 347
            ......:|...:.:..|..:   |...|.::|:.....|.                .|.::::|
Worm  1837 MFAFDSEDAVKKVVYQLPRVGVGVKYGLPQSRKTSLMTPR----------------QLFKHSDMC 1885

  Fly   348 --WCNGQLSNFDYLTILNNACGRSLTNAAYHHIMPWV-TDFSG-----RGGGAWRDLTKSKYRLN 404
              |...::||||||..||...||:..:.:.:.:.||: |:::.     .....:|||:|....|:
Worm  1886 AKWQKREISNFDYLMFLNTVAGRTFNDLSQYPVFPWILTNYTSDTLDLSVASNFRDLSKPIGALS 1950

  Fly   405 KGDVHLDLMYAHASQHGSADGSYQAIGDQAP--HHVSDFLSEITYFVYMARRTPQSILCAHV--- 464
            :           |.:....|.......||.|  |:.:.:.:......::.|..|.:.:..::
Worm  1951 E-----------ARRKFFNDRYTSWDDDQVPAFHYGTHYSTPAFTLNWLLRVEPFASMFINLHDG 2004

  Fly   465 ---RPIWVPAEYPVSIQRLQEWTPD--ECIPEFYSDPMIFKSIHE----------DLPDLELPAW 514
               .|..:......|..|.|..:.|  |.|||.:..|.:|::..:          .:.|:.||.|
Worm  2005 KFDHPDRITHSIKDSWDRCQRDSHDVKELIPELFYLPEMFRNSSKFNLGRRADGTPVDDVVLPPW 2069

  Fly   515 ATCPEDFICKHREALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNVCLTLVDQHRNLSQRGIV- 578
            |..||.|:..||:||||..||.:|:.||||.||||..|..||::.||       ..:|:..|.|
Worm  2070 AESPEHFVLMHRQALESDLVSCQLNQWIDLIFGYKQRGAEAVRATNV-------FYHLTYEGTVT 2127

  Fly   579 -------------------------QLFASAHPPRR----YATPWFSRTAPRLSQLYA----SPA 610
                                     ||...|||||.    .|...|.|....|..:..    ||.
Worm  2128 PKMAETPGQVAAIEQQILSFGQTPSQLLTEAHPPRHSIMSMAPTMFRRHDEDLCMMMKYISNSPV 2192

  Fly   611 KRLAKST-------------ENL----------------------------------------QA 622
            ..||.:|             :||                                        |.
Worm  2193 VYLAANTFHQLPQPTVVGVAQNLVFSLNKWDNSYSYGASQRSALSMDPSNAEGQVSLPLTADAQL 2257

  Fly   623 ESATGSSHLSLR-LGD-----------------------------------DGSSGSVHSS---- 647
            .||..::.::.| |||                                   |..||.|..:
Worm  2258 ASAASTTPVARRHLGDAFDQRLTVQCSNFVTTTDSKFIFACGYPDYSFRIVDTDSGRVRQAVYGH 2322

  Fly   648 ---------SASASASNFYAITNFIELPENYNPALLLHNLETLEAFYARTF------PQQRASAN 697
                     |.::..|:.|.:|..::.      .::|.:......|.|..:      |..|:...
Worm  2323 GDVVTCIARSETSLFSDCYVVTGSMDC------TVVLWHWNGTTGFIAGEYNQPGEVPSPRSILT 2381

  Fly   698 PEEKMISSDLMFEQNSAEHSFTNQLFASGDE-----LPPKSKNLLREKR-NCLQHLLNVRKERDL 756
            ..|..||:..:    ||||.    |..||.|     :...|.:|||..| :.:...|::.:|
Worm  2382 GHEASISALCV----SAEHG----LVVSGCEDGVILIHTTSSDLLRRIRGHGIVTQLSMSRE--- 2435

  Fly   757 HVLGCLIIELFAMQRL 772
                |:::.||..:|:
Worm  2436 ----CILLSLFDSKRM 2447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	77/297 (26%)
		WD40	<1644..1877	CDD:225201
		WD40	1651..1876	CDD:295369
		WD40 repeat	1662..1705	CDD:293791
		WD40 repeat	1710..1744	CDD:293791
		WD40 repeat	1752..1788	CDD:293791
		WD40 repeat	1799..1836	CDD:293791
sel-2	NP_001379017.1	LamG	384..530	CDD:419873
		DUF4704	605..870	CDD:406270
		DUF1088	1569..1733	CDD:399463	16/72 (22%)
		PH_BEACH	1757..1854	CDD:405526	20/114 (18%)
		Beach	1887..2162	CDD:396627	76/292 (26%)
		WD40 repeat	2283..2321	CDD:293791	4/37 (11%)
		WD40	2291..2535	CDD:421866	35/178 (20%)
		WD40 repeat	2327..2382	CDD:293791	9/60 (15%)
		WD40 repeat	2387..2422	CDD:293791	14/42 (33%)
		WD40 repeat	2430..2462	CDD:293791	6/25 (24%)
		WD40 repeat	2466..2502	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910