DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr81 and atg-16.2

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	NP_495299.2	Gene:	atg-16.2 / 174067	WormBaseID:	WBGene00019427	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	433	Identity:	88/433 - (20%)
Similarity:	160/433 - (36%)	Gaps:	105/433 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1478 NKAFGLPN------DFACDLANLSLVGGASQPERALEELRDV---------FGPELAHTAYLTFL 1527
            |:.|.|.|      :.:.:..|..:   |.|.|||...:|:.         .|.|.|.:|:.|..
Worm   160 NERFQLLNRIRELQEKSAEFMNAEI---ALQEERAQMRIREQIAKATADLNLGDERASSAFGTSP 221

  Fly  1528 RFLGEANMKRTLSNLDFVLTLCHEHEQPNGQSKIQLATNVSSGQDVDSVDASCELAANSFGTQIV 1592
            ..|.|..|...|.:                :.|.:|:|:.....||:      .::.::|.|...
Worm   222 ETLDEFMMTDVLPS----------------EVKFKLSTHDGEVHDVE------WMSDDTFATAGS 264

  Fly  1593 GNRLQVARNNVELIDMVAYKLDQMPKTRHLKG-----NWLAYWRNE----TTRNEKDTQTLNLKQ 1648
            .:::|:.|        |:.......|...|.|     |.|.|....    .:.|:|..:..|:..
Worm   265 DSKVQIWR--------VSPNKTDASKVSTLSGCLGPVNRLDYDSQRHVCLASSNDKTCRLWNIDS 321

  Fly  1649 IRLQS-FVGHTNSVRAIYALDNENSFISASKDKTVKLWSLRSEGDGRKTSACQFTY--------T 1704
            .||.| |.|||:.|.:.....:.| .||.|.|:|:|.|.:.|       ..|..:|        .
Worm   322 QRLLSTFSGHTDKVSSARLFQSHN-VISGSADRTIKNWDISS-------IRCLKSYLVGSTVFDI 378

  Fly  1705 AHKKSINSLGFLESLRYVVSCDSGIHLWDP---------FIGRPLSVLDAPRHSAVTVVKCLPSH 1760
            ..|..::...|:.|     ..|..:..||.         .:|:.:|.||            :...
Worm   379 VAKCGVSQSSFISS-----HFDKKVRFWDARSSDATYSVELGQKVSSLD------------ISMD 426

  Fly  1761 SPLVIAGTAESTVKMVDARSCEYVNEWRVCNASLPNATVRCLAVAPSGNWLAAGLSSGCIVQLDT 1825
            ...|:|.:.:.|:.::|.|:...::.:..........:.|.: .:.:|.::.||.|:..:...:|
Worm   427 GLQVLASSRDDTLSLIDVRNYGIIHLYSAEQYKTSCDSTRAI-FSSTGEYVLAGSSNSSVFIWNT 490

  Fly  1826 RT---GMVINSWRPMECDLLQLA-APSDQFLVSSALDHSLAVW 1864
            :|   ..|:.:.|.....::.|| .||.:.|::.....:..:|
Worm   491 KTTKLEKVVKTARSDSAQIMSLAWNPSGRGLLACDRQKTCTLW 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117
		WD40	<1644..1877	CDD:225201	50/243 (21%)
		WD40	1651..1876	CDD:295369	48/236 (20%)
		WD40 repeat	1662..1705	CDD:293791	11/50 (22%)
		WD40 repeat	1710..1744	CDD:293791	7/42 (17%)
		WD40 repeat	1752..1788	CDD:293791	5/35 (14%)
		WD40 repeat	1799..1836	CDD:293791	8/39 (21%)
atg-16.2	NP_495299.2	ATG16	11..181	CDD:285778	4/20 (20%)
		DUF904	107..175	CDD:299763	4/14 (29%)
		WD40	<231..499	CDD:225201	61/323 (19%)
		WD40	241..524	CDD:238121	66/322 (20%)
		WD40 repeat	294..330	CDD:293791	10/35 (29%)
		WD40 repeat	335..371	CDD:293791	12/43 (28%)
		WD40 repeat	379..411	CDD:293791	6/36 (17%)
		WD40 repeat	418..456	CDD:293791	8/49 (16%)
		WD40 repeat	464..502	CDD:293791	8/38 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910