DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr81 and WDR81

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	NP_001157281.1	Gene:	WDR81 / 124997	HGNCID:	26600	Length:	1941	Species:	Homo sapiens

Alignment Length:	2151	Identity:	658/2151 - (30%)
Similarity:	968/2151 - (45%)	Gaps:	455/2151 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EIGVDPQHVCEAGGDGRFQVICDKAWLQSLERNRRLTHFPSWP--------------LLDRRSYP 60
            ::.:||:.:..|.|......:....||.|| |:|||   |..|              ||.|   .
Human    37 DLSIDPRQLAPAPGGTHVVALVPARWLASL-RDRRL---PLGPCPRAEGLGEAEVRTLLQR---S 94

  Fly    61 IGQLEHPWTRILVQTYRKQPQSRVYPLPRISGDAP---SSELPLSYSQAVSFVAHSNFKQLWEEA 122
            :.:|...|||:.|...||:..|  |||   .|..|   .|..|.:.::.:..||..|::.||..|
Human    95 VQRLPAGWTRVEVHGLRKRRLS--YPL---GGGLPFEDGSCGPETLTRFMQEVAAQNYRNLWRHA 154

  Fly   123 YRKYNGAHVRMCRSTPSAPSTKPPSGQGQLQPHDVVLKELIQRVYRCPVL------HC-QLDRDG 180
            |..|...:     |...|||..|....         :::.:||||.|..|      .| ...|:|
Human   155 YHTYGQPY-----SHSPAPSAVPALDS---------VRQALQRVYGCSFLPVGETTQCPSYAREG 205

  Fly   181 VSDSSNATSCSAGSCHANVLPALVAIETSTHISVFFY--PPALECSLYDCITFSPALLGKNYNKT 243
            ......:.:|          |:|:..|.........|  .|.::.||:|.:|||||.|..:..|.
Human   206 PCPPRGSPAC----------PSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKV 260

  Fly   244 LFVIYQILQLAKHLQGQGLFLGDLRLQDIVLRENLWLQVLPRLQCNLLDDDPAGEDMSPLTPLVS 308
            ||:::::|:.......|||..|.|.|..|.:.|.|    ...|:.:|...:...||.:...|:..
Human   261 LFILFRVLRAMDACHRQGLACGALSLYHIAVDEKL----CSELRLDLSAYERPEEDENEEAPVAR 321

  Fly   309 EDLG-EAREAQQALPSSSTMFDLRFAYDPAHFNLREYTEMWCNGQLSNFDYLTILNNACGRSLTN 372
            ::.| .::|.|...|...|          ....||.....|.:|::|||.||..||...||...:
Human   322 DEAGIVSQEEQGGQPGQPT----------GQEELRSLVLDWVHGRISNFHYLMQLNRLAGRRQGD 376

  Fly   373 AAYHHIMPWVTDFSGRGGGAWRDLTKSKYRLNKGDVHLDLMYAHASQHGSADGSYQAIGDQAPHH 437
            ..||.::|||.||: ...|.:|||.|||:||||||..||..|....|...|.|:........|||
Human   377 PNYHPVLPWVVDFT-TPHGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHH 440

  Fly   438 VSDFLSEITYFVYMARRTPQSILCAHVRPIWVPAEYPVSIQRLQEWTPDECIPEFYSDPMIFKSI 502
            :||.||:|||:||.|||||:|:||.|||..|.|.|||.|::|:|.|||||||||||:||.||:||
Human   441 ISDVLSDITYYVYKARRTPRSVLCGHVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIFRSI 505

  Fly   503 HEDLPDLELPAWATCPEDFICKHREALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNVCLTLVD 567
            |.|:|||::|||.:..::|:..||..|||:.||..|||||||.|||||.||.|||.|||||.|||
Human   506 HPDMPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVD 570

  Fly   568 QHRNLSQRGIVQLFASAHPPRRYATPWFSRTAPRLSQLY-------------------------- 606
            .|.:|:..|:||||...||.|....|..:...|.:.:|.
Human   571 AHTHLASYGVVQLFDQPHPQRLAGAPALAPEPPLIPKLLVQTIQETTGREDFTENPGQLPNGVGR 635

  Fly   607 ----ASPAKR-------------LAKSTENLQAESATGSSHLSLRLGDDGSSGSVHSSSASAS-- 652
                |:|.:.             |.::||.|.:.|..|.:...|......|.|.:..|.||||
Human   636 PVLEATPCEASWTRDRPVAGEDDLEQATEALDSISLAGKAGDQLGSSSQASPGLLSFSVASASRP 700

  Fly   653 --------ASNFYAITNFIELPENYNPALLLHNLETLEAFYARTFPQQRASANPEEKMISSDLMF 709
                    |.........|.|||.:||...|..||....|.|:..               ..|:
Human   701 GRRNKAAGADPGEGEEGRILLPEGFNPMQALEELEKTGNFLAKGL---------------GGLL- 749

  Fly   710 EQNSAEHSFTNQLFASGDELPPKSKNLLREKRNCLQHLLNVRKERDLHVLGCLIIELFAMQRLRP 774
                              |:|.:.:........||.|       ||:..||.|:.|:....|:|.
Human   750 ------------------EVPEQPRVQPAVPLQCLLH-------RDMQALGVLLAEMVFATRVRT 789

  Fly   775 LLMGNGLTATFDSRLSACRTVAQLHRQELPKPVRRVVRLLLQLEQP----GEE------------ 823
            |.....|..    |..|.|.:...|.:|:|..::.|:..|||:..|    |.|
Human   790 LQPDAPLWV----RFQAVRGLCTRHPKEVPVSLQPVLDTLLQMSGPEVPMGAERGKLDQLFEYRP 850

  Fly   824 -DQGLPQPPNPAQLLEPMFSNLLLPFPSHYMAVYALVRSLHAFEANAVLLELQTHFSCKGGRECE 887
             .|||| ||.|:|||.|..|  ::|||.::.|::   |.:..::|..|..|.|       |||.
Human   851 VSQGLP-PPCPSQLLSPFSS--VVPFPPYFPALH---RFILLYQARRVEDEAQ-------GREL- 901

  Fly   888 RYTEMDRQRVLFERKIAECKVMSCCAHVKRLLEPMSFAYEQFTP--VELLLPHIIDLLRDERTSI 950
                                       |..|.:.:....:..||  :|:|||.::.|:.:|.|::
Human   902 ---------------------------VFALWQQLGAVLKDITPEGLEILLPFVLSLMSEEHTAV 939

  Fly   951 LTAWNLFDPIAQALGVSQTQQHLLQPLLKLYDVESVSSPDDGGSNGSTNSGGHLRFSASSSFKSR 1015
            .|||.||:|:|:|||.....::||:||:..|:     ||          ...|.||
Human   940 YTAWYLFEPVAKALGPKNANKYLLKPLIGAYE-----SP----------CQLHGRF--------- 980

  Fly  1016 KSVKLYHHSFLLRLIVRFGLRCFLHHFIAPLIEAVGGYKEPEQGNGYHYHSGGSRRTSKNLNFAS 1080
               .||...|:.:|:||.||:.||.|.:..:::.:.|             :..|:..||:|..|:
Human   981 ---YLYTDCFVAQLMVRLGLQAFLTHLLPHVLQVLAG-------------AEASQEESKDLAGAA 1029

  Fly  1081 ENE------------VHQTEVAPEMK---------PDIEELFTFEDDHDRASTQDSKSIDSFDMR 1124
            |.|            ....|:..:.:         ||.....:|.|..|...|:|.::.......
Human  1030 EEEESGLPGAGPGSCAFGEEIPMDGEPPASSGLGLPDYTSGVSFHDQADLPETEDFQAGLYVTES 1094

  Fly  1125 PSTSAASAEEARESDGSPDKLVINELIYGARISPDKLSLKESQTPPALVPPPIGPRSPTIEIPMG 1189
            |....|.|                       :|..:||.|.|                |.|..:|
Human  1095 PQPQEAEA-----------------------VSLGRLSDKSS----------------TSETSLG 1120

  Fly  1190 ----PTAGGIRRSFQLSAIDCDIGSRKSVDSFDLISQAVEQLPPPAEESEAE------------- 1237
                |..||         ...|..|.:|.||    ||.::|.....||.|.|
Human  1121 EERAPDEGG---------APVDKSSLRSGDS----SQDLKQSEGSEEEEEEEDSCVVLEEEEGEQ 1172

  Fly  1238 -----ASD-SLQASVIS---------------------RLSEAKAVQNNRISEMSAESLVWLSHR 1275
                 ||: :|..:|:|                     ..||.|  :...:.:.:.:.:.|||.:
Human  1173 EEVTGASELTLSDTVLSMETVVAGGSGGDGEEEEEALPEQSEGK--EQKILLDTACKMVRWLSAK 1235

  Fly  1276 LGPVLTSRFITRNLLKLLSLCYVGQENLLPEVDDGGSSFNSSPDAANLNYFSIANARVVGDRSAA 1340
            |||.:.||.:.||||:||:.||||.......|..|     .||..:..|.:.  ...|:||..:.
Human  1236 LGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSSG-----ESPPLSAGNIYQ--KRPVLGDIVSG 1293

  Fly  1341 RVLECLMSIAALYGENFLLLQYFPHISELISLCS----KRITGSLEGAIISSLQLLKYMVPCLTD 1401
            .||.||:.||.||||..|..||.|:||.|::..|    .|:....|..:::::.|.:.::..|:|
Human  1294 PVLSCLLHIARLYGEPVLTYQYLPYISYLVAPGSASGPSRLNSRKEAGLLAAVTLTQKIIVYLSD 1358

  Fly  1402 ASIMEHLQHIMLDAILLPILRLLSSTNLVMPSGYLGRSLLARKFLDAIYALSVRLGSDMTREHLC 1466
            .::|:.|..|..: :|||:|..|:|.....|||...|::|..|.:..|..:.:|:|.:|.::||.
Human  1359 TTLMDILPRISHE-VLLPVLSFLTSLVTGFPSGAQARTILCVKTISLIALICLRIGQEMVQQHLS 1422

  Fly  1467 QPLLNPFFLIFNKAFGL-PNDFACD--------LANLSLVGGASQP--ERALEELRDVFGPELAH 1520
            :|:.. ||.:|::...| ..|...|        |..:....|..:|  ...|:||:.||..|:|:
Human  1423 EPVAT-FFQVFSQLHELRQQDLKLDPAGRGEGQLPQVVFSDGQQRPVDPALLDELQKVFTLEMAY 1486

  Fly  1521 TAYLTFLRFLGEANMKRTLSNLDFV---LTLCHEHEQPNGQSKIQL-ATNVSSGQDVDSVDASC- 1580
            |.|:.|...||:. :::.:.|.:.|   ..|..|...|:.::...: .|...:|.:.|.....|
Human  1487 TIYVPFSCLLGDI-IRKIIPNHELVGELAALYLESISPSSRNPASVEPTMPGTGPEWDPHGGGCP 1550

  Fly  1581 --ELAANSFGTQIVGNRLQVARNN----------VELI---------DMVAYKLDQMPKTRH-LK 1623
              :..:.:||:.:||||:|:..::          :..:         |..|.| .::|::.| |.
Human  1551 QDDGHSGTFGSVLVGNRIQIPNDSRPENPGPLGPISGVGGGGLGSGSDDNALK-QELPRSVHGLS 1614

  Fly  1624 GNWLAYWRNETTRNEKDTQTLNLKQIRLQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWSLR 1688
            |||||||:.|...:::|.. .:..|||||||.||:.:|:.:..|.:|:.|:|.|||:||:||.|.
Human  1615 GNWLAYWQYEIGVSQQDAH-FHFHQIRLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLY 1678

  Fly  1689 SEGDGRKTSACQFTYTAHKKSINSLGFLESLRYVVSCDSGIHLWDPFIGRPLSVLDAPRHSAV-- 1751
            :.|||...:|.:..||.|:||:..:|.||:.::|||||..:|:||||.|:.|..:: |..|.|
Human  1679 NYGDGTSETAPRLVYTQHRKSVFFVGQLEAPQHVVSCDGAVHVWDPFTGKTLRTVE-PLDSRVPL 1742

  Fly  1752 TVVKCLPSHSPLVIAGTAESTVKMVDARSCEYVNEWRVCNASLPNATVRCLAVAPSGNWLAAGLS 1816
            |.|..:|:....:...:::||::.||.|.....:|:|: ...|....||.||::|||..:.||.|
Human  1743 TAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRL-GGGLNPGLVRALAISPSGRSVVAGFS 1806

  Fly  1817 SGCIVQLDTRTGMVINSWRPMECDLLQLAAPSDQFLVSSALDHSLAVWHALDGIMHYQLKPPPEP 1881
            ||.:|.||||||:|:..|...|.|:||:.|.....||||:.||||.||..|:....:..|...:|
Human  1807 SGFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDP 1871

  Fly  1882 AHFLQSVGPSLVYATTGNRVGVYADVAHSHAFSTITKLRSETFRGVLTSLAVLPLNRAFLAGNES 1946
            .|.....|..:|..|..|::|| ..:....:.:| |||.||.|||.|||||:||..|..|.|:::
Human  1872 IHTFDLYGSEVVTGTVSNKIGV-CSLLEPPSQAT-TKLSSENFRGTLTSLALLPTKRHLLLGSDN 1934

  Fly  1947 GNIALL 1952
            |.|.||
Human  1935 GVIRLL 1940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	135/242 (56%)
		WD40	<1644..1877	CDD:225201	97/234 (41%)
		WD40	1651..1876	CDD:295369	94/226 (42%)
		WD40 repeat	1662..1705	CDD:293791	17/42 (40%)
		WD40 repeat	1710..1744	CDD:293791	15/33 (45%)
		WD40 repeat	1752..1788	CDD:293791	9/35 (26%)
		WD40 repeat	1799..1836	CDD:293791	21/36 (58%)
WDR81	NP_001157281.1	Necessary and sufficient for the interaction with SQSTM1. /evidence=ECO:0000269\|PubMed:28404643	1..650		235/663 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Beach	351..591	CDD:100117	135/240 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..637		0/18 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..718		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1022..1074		9/51 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1097..1217		33/173 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1523..1556		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1569..1602		2/32 (6%)
		WD40	1631..>1939	CDD:225201	128/312 (41%)
		WD 1	1639..1677		20/37 (54%)
		WD40	<1641..1855	CDD:295369	92/215 (43%)
		WD40 repeat	1652..1695	CDD:293791	17/42 (40%)
		WD 2	1686..1724		16/37 (43%)
		WD40 repeat	1700..1734	CDD:293791	15/33 (45%)
		WD 3	1729..1769		10/40 (25%)
		WD40 repeat	1743..1779	CDD:293791	9/35 (26%)
		WD 4	1777..1815		17/38 (45%)
		WD40 repeat	1789..1822	CDD:293791	20/32 (63%)
		WD 5	1819..1856		17/36 (47%)
		WD40 repeat	1831..1864	CDD:293791	14/32 (44%)
		WD 6	1860..1896		9/36 (25%)
		WD40 repeat	1871..1893	CDD:293791	6/21 (29%)
		WD 7	1902..1941		23/40 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152581
Domainoid	1	1.000	271	1.000	Domainoid score	I1828
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13983
Inparanoid	1	1.050	772	1.000	Inparanoid score	I534
Isobase	1	0.950	-	0	Normalized mean entropy	S7651
OMA	1	1.010	-	-		QHG48726
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	1	1.000	-	-		FOG0006096
OrthoInspector	1	1.000	-	-		oto89327
orthoMCL	1	0.900	-	-		OOG6_105710
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2948
SonicParanoid	1	1.000	-	-		X4393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.650