DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF391 and CG18476

DIOPT Version :9

Sequence 1:	NP_001070249.1	Gene:	ZNF391 / 346157	HGNCID:	18779	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	291	Identity:	94/291 - (32%)
Similarity:	130/291 - (44%)	Gaps:	73/291 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   133 GEKP-FECNKCGKSFSRSTHLIEHQRT-HTGEK-PYECNEC-GKAFSRSTHLSLHQR---IHTGE 190
            |.:| :.|..|.....|...:|:|||| |..:| |:||::| .|..|:|  :..|.|   ..:.|
  Fly   631 GSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKS--IMDHHRQGQCSSTE 693

Human   191 KPYECSECGKAFSRSTNLSQH---QRT-----------HTQ----------------------ER 219
            |.:.|.:|...|....||.||   |.:           |||                      :|
  Fly   694 KKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHCDR 758

Human   220 PYK----------------------------CNECGKAFGDRSTIIQHQRIHTGENPYECSKCGK 256
            .|:                            |:.||......:.::.|.|.||||.|::|..|..
  Fly   759 TYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEM 823

Human   257 AFSWISSLTEHQRTHTGENPYECSECGKVFSRSSSLTEHQRIHSGEKPHECRVCGKGFSRSSSLI 321
            ||...|.|..|:|.||||.|:.|:.|||.|:||..|..|...|||.|||:|..|.|.:.::..|.
  Fly   824 AFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLK 888

Human   322 IHQRTHTGEKPYKCNDCGKAFCQSSTLIRHQ 352
            :|.:.||||.|:.|..||:.|.|||||.:|:
  Fly   889 LHLQQHTGECPFVCGTCGERFIQSSTLEKHR 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF391	NP_001070249.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..94
		C2H2 Zn finger	111..131	CDD:275368
		zf-H2C2_2	123..148	CDD:290200	4/15 (27%)
		C2H2 Zn finger	139..159	CDD:275368	8/20 (40%)
		zf-H2C2_2	151..176	CDD:290200	12/27 (44%)
		COG5048	<163..340	CDD:227381	75/245 (31%)
		C2H2 Zn finger	167..187	CDD:275368	7/23 (30%)
		zf-H2C2_2	179..204	CDD:290200	7/27 (26%)
		C2H2 Zn finger	195..215	CDD:275368	8/33 (24%)
		zf-H2C2_2	207..230	CDD:290200	13/86 (15%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		zf-H2C2_2	238..259	CDD:290200	10/20 (50%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		zf-H2C2_2	263..288	CDD:290200	13/24 (54%)
		C2H2 Zn finger	279..299	CDD:275368	9/19 (47%)
		zf-H2C2_2	291..316	CDD:290200	11/24 (46%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		zf-H2C2_2	319..342	CDD:290200	10/22 (45%)
		zf-C2H2	333..355	CDD:278523	10/20 (50%)
		C2H2 Zn finger	335..355	CDD:275368	10/18 (56%)
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	401..422	CDD:275368
		C2H2 Zn finger	431..447	CDD:275368
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	490..511	CDD:275368
		C2H2 Zn finger	520..540	CDD:275368
		C2H2 Zn finger	638..659	CDD:275368	8/20 (40%)
		C2H2 Zn finger	668..690	CDD:275368	7/23 (30%)
		C2H2 Zn finger	698..715	CDD:275368	6/16 (38%)
		C2H2 Zn finger	753..774	CDD:275368	2/20 (10%)
		C2H2 Zn finger	790..810	CDD:275368	5/19 (26%)
		zf-H2C2_2	802..825	CDD:290200	9/22 (41%)
		COG5048	814..>886	CDD:227381	32/71 (45%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	13/24 (54%)
		C2H2 Zn finger	846..866	CDD:275368	9/19 (47%)
		zf-H2C2_2	859..883	CDD:290200	11/23 (48%)
		C2H2 Zn finger	874..894	CDD:275368	5/19 (26%)
		C2H2 Zn finger	902..924	CDD:275368	10/18 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910