DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF391 and hic2

DIOPT Version :9

Sequence 1:	NP_001070249.1	Gene:	ZNF391 / 346157	HGNCID:	18779	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_878289.2	Gene:	hic2 / 359828	ZFINID:	ZDB-GENE-030619-1	Length:	560	Species:	Danio rerio

Alignment Length:	331	Identity:	95/331 - (28%)
Similarity:	152/331 - (45%)	Gaps:	58/331 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     9 AQGPTNEEDYKNEGQLSRQTKCPAQKKSSFEN----TVVRKVSVTLKEIFTGEEGPESSEFSLSP 69
            :|.|.:.:.:|:..|::||.:.|..:....|:    |:...||..||  ..||..|..
Zfish   274 SQPPPDVDQHKSSRQVTRQRRQPKSEGKKGEDMERVTLPNGVSKRLK--VAGERLPAG------- 329

Human    70 NLDAQQKIPKGHGSPISRKNSKDNSDLIKHQRLFSQRKPCKCNECEKAFSYQSDLLVHSRIHGGE 134
                      |:|:.......||..:.:::.:..|:.            |.||:
Zfish   330 ----------GNGNSEVSFQCKDEEEGLENGQEQSEE------------SGQSE----------- 361

Human   135 KPFECNKCGKSFSRSTHLIEHQRTHTGEKPYECNECGKAFSRSTHLSLHQRIHTGEKPYECSECG 199
                 |:.|::.:...:..|......|:..|.|..|||.|..|..|:.|...||.|:.|...|..
Zfish   362 -----NEGGRNSANYVYRQEGFEPALGDNLYVCIPCGKGFPSSEELNAHVETHTEEELYIKEEDN 421

Human   200 KAFSRSTNL------SQHQRTH-TQERPYKCNECGKAFGDRSTIIQHQRIHTGENPYECSKCGKA 257
            .::.:...:      ||..:.| |:.|.:.|:.|.|::.|.:|:.||::.|....|:.|:.|||.
Zfish   422 DSYPKEDEVEAEDLSSQITQVHGTETRRFSCSVCNKSYKDPATLRQHEKTHWLTRPFPCNICGKM 486

Human   258 FSWISSLTEHQRTHTGENPYECSECGKVFSRSSSLTEHQRIHSGEKPHECRVCGKGFSRSSSLII 322
            |:...::|.|.|:|.|..|:.|.|||..|:|...||||.|:||||||:||::||..|::..:||.
Zfish   487 FTQRGTMTRHMRSHLGLKPFACEECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLIS 551

Human   323 HQRTHT 328
            |.|.||
Zfish   552 HLRMHT 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF391	NP_001070249.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..94		7/37 (19%)
		C2H2 Zn finger	111..131	CDD:275368	3/19 (16%)
		zf-H2C2_2	123..148	CDD:290200	2/24 (8%)
		C2H2 Zn finger	139..159	CDD:275368	3/19 (16%)
		zf-H2C2_2	151..176	CDD:290200	8/24 (33%)
		COG5048	<163..340	CDD:227381	67/173 (39%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	7/24 (29%)
		C2H2 Zn finger	195..215	CDD:275368	3/25 (12%)
		zf-H2C2_2	207..230	CDD:290200	8/29 (28%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		zf-H2C2_2	238..259	CDD:290200	8/20 (40%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		zf-H2C2_2	263..288	CDD:290200	11/24 (46%)
		C2H2 Zn finger	279..299	CDD:275368	11/19 (58%)
		zf-H2C2_2	291..316	CDD:290200	16/24 (67%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		zf-H2C2_2	319..342	CDD:290200	6/10 (60%)
		zf-C2H2	333..355	CDD:278523
		C2H2 Zn finger	335..355	CDD:275368
hic2	NP_878289.2	BTB	18..118	CDD:279045
		BTB	25..120	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..163
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..367		26/139 (19%)
		C2H2 Zn finger	389..409	CDD:275368	8/19 (42%)
		zf-C2H2	450..472	CDD:278523	7/21 (33%)
		C2H2 Zn finger	452..472	CDD:275368	7/19 (37%)
		zf-C2H2	478..500	CDD:278523	8/21 (38%)
		C2H2 Zn finger	480..500	CDD:275368	8/19 (42%)
		zf-H2C2_2	493..517	CDD:290200	11/23 (48%)
		C2H2 Zn finger	508..528	CDD:275368	11/19 (58%)
		zf-H2C2_2	521..545	CDD:290200	16/23 (70%)
		C2H2 Zn finger	536..556	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910