DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh5 and OPN1MW2

DIOPT Version :9

Sequence 1:	NP_001285859.1	Gene:	Rh5 / 34615	FlyBaseID:	FBgn0014019	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001041646.1	Gene:	OPN1MW2 / 728458	HGNCID:	26952	Length:	364	Species:	Homo sapiens

Alignment Length:	361	Identity:	90/361 - (24%)
Similarity:	165/361 - (45%)	Gaps:	68/361 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 RGFREAPIY-------YH-AGFYIAFIVLMLSSIFGNGLVIWIFSTSKSLRTPSNLLILNLAIFD 98
            ||..|.|.|       || ...::.|:|  ::|:|.||||:......|.||.|.|.:::|||:.|
Human    37 RGPFEGPNYHIAPRWVYHLTSVWMIFVV--IASVFTNGLVLAATMKFKKLRHPLNWILVNLAVAD 99

  Fly    99 L---FMCTNMPHYLINATVGYIVGGDLGCDIYALNG------GISGMGASITNAFIAFDRYKTIS 154
            |   .:.:.:.  ::|...||.|   ||..:..|.|      ||:|:.:.   |.|:::|:..:.
Human   100 LAETVIASTIS--VVNQVYGYFV---LGHPMCVLEGYTVSLCGITGLWSL---AIISWERWMVVC 156

  Fly   155 NP-----IDGRLSYGQIVLLILFTWLWATPFSVLPLFQIWGRYQPEGFLTTCSFDYLTNTDEN-- 212
            .|     .|.:|:    ::.|.|:|:||..::..|:|. |.||.|.|..|:|..|..:.:...
Human   157 KPFGNVRFDAKLA----IVGIAFSWIWAAVWTAPPIFG-WSRYWPHGLKTSCGPDVFSGSSYPGV 216

  Fly   213 RLFVRTIFVWSYVIPMTMILVSYYKLFTHVRVHEKMLAEQAKKMNVKSLSANANADNMSVELRIA 277
            :.::..:.|...:.|:::|::.|.:::..:|.    :|:|.|:          :......|..:.
Human   217 QSYMIVLMVTCCITPLSIIVLCYLQVWLAIRA----VAKQQKE----------SESTQKAEKEVT 267

  Fly   278 KAALIIYMLFILAWTPYSVVALIGCFGEQQLITPF---VSMLPCLACKSVSCLDPWVYATSHPKY 339
            :..:::.:.|...|.||   |...||.......||   ::.||....||.:..:|.:|...:.::
Human   268 RMVVVMVLAFCFCWGPY---AFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYVFMNRQF 329

  Fly   340 R---LELERRLPWLGIREKHATSGTSGGQESVASVS 372
            |   |:|      .|.:....:..:|..:..|:|||
Human   330 RNCILQL------FGKKVDDGSELSSASKTEVSSVS 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh5	NP_001285859.1	7tm_4	60..>236	CDD:304433	52/191 (27%)
Rh5	NP_001285859.1	7tm_1	69..332	CDD:278431	69/281 (25%)
OPN1MW2	NP_001041646.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000269\|PubMed:30948514	17..43		3/5 (60%)
		7tm_4	61..>178	CDD:304433	37/130 (28%)
		7tm_1	71..322	CDD:278431	69/280 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910