Protein Alignment Rh5 and RGR

DIOPT Version :10

• Sequence 1: NP_477096.1
• Gene: Rh5 / 34615
• FlyBaseID: FBgn0014019
• Length: 382
• Species: Drosophila melanogaster
• Sequence 2: NP_002912.2
• Gene: RGR / 5995
• HGNCID: 9990
• Length: 295
• Species: Homo sapiens
• Alignment Length: 314
• Identity: 81/314 - (25%)
• Similarity: 138/314 - (43%)
• Gaps: 55/314 - (17%)

  Fly    60 IVLMLSSIFG---NGLVIWIFSTSKSLRTPSNLLILNLAIFDLFMCTNMPHYLINATVGYI---- 117
            :||::.::.|   |.|.|:.|..:..||||.:||:|:||:.|..:..|.   |:.||...:
Human    21 MVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNA---LVAATSSLLRVSH 82

  Fly   118 ----VGGDLGCDIYALNGGISGMGASITNAFIAFDRYKTISNPIDGRLSYGQIVLLILFTWLWAT 178
                .|.| ||..:...|.::.:.:..::|.||:.||.....  ..:|::...|.|:||.||.:.
Human    83 RRWPYGSD-GCQAHGFQGFVTALASICSSAAIAWGRYHHYCT--RSQLAWNSAVSLVLFVWLSSA 144

  Fly   179 PFSVLPLFQIWGRYQPEGFLTTCSFDYLTNTDENRLFVRTIFVWSYVIPMTMILVSYYKLFTHVR 243
            .::.|||.. ||.|..|...|.|:.||.........|:.|:..:::.:|:.:.:.||
Human   145 FWAALPLLG-WGHYDYEPLGTCCTLDYSKGDRNFTSFLFTMSFFNFAMPLFITITSY-------- 200

  Fly   244 VHEKMLAEQAKKMNVKSLSANANADNMSVELRIAKAALIIYMLFILAWTPYSVVALIGCFGEQQL 308
                .|.||  |:        ..:.::.|...:....|      :|.|.||:::.|.....:...
Human   201 ----SLMEQ--KL--------GKSGHLQVNTTLPARTL------LLGWGPYAILYLYAVIADVTS 245

  Fly   309 ITPFVSMLPCLACKSVSCLDPWVYATSHPKYRLELERRLPWLGI----REKHAT 358
            |:|.:.|:|.|..|.|..::...||..:     |:..|..|..:    |||..|
Human   246 ISPKLQMVPALIAKMVPTINAINYALGN-----EMVCRGIWQCLSPQKREKDRT 294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rh5	NP_477096.1	7tmA_photoreceptors_insect	54..343	CDD:320207	74/293 (25%)
		TM helix 1	54..80	CDD:320207	7/22 (32%)
		TM helix 2	87..112	CDD:320207	8/24 (33%)
		TM helix 3	124..154	CDD:320207	7/29 (24%)
		TM helix 4	164..184	CDD:320207	6/19 (32%)
		TM helix 5	212..241	CDD:320207	5/28 (18%)
		TM helix 6	271..301	CDD:320207	7/29 (24%)
		TM helix 7	311..336	CDD:320207	8/24 (33%)
RGR	NP_002912.2	7tmA_Retinal_GPR	17..281	CDD:320200	76/299 (25%)
		TM helix 1	18..44	CDD:320200	7/22 (32%)
		TM helix 2	51..77	CDD:320200	10/28 (36%)
		TM helix 3	92..122	CDD:320200	7/29 (24%)
		TM helix 4	130..150	CDD:320200	6/19 (32%)
		TM helix 5	177..206	CDD:320200	8/42 (19%)
		TM helix 6	208..238	CDD:320200	7/35 (20%)
		TM helix 7	248..273	CDD:320200	8/24 (33%)