Protein Alignment Rh5 and OPN1MW

DIOPT Version :10

• Sequence 1: NP_477096.1
• Gene: Rh5 / 34615
• FlyBaseID: FBgn0014019
• Length: 382
• Species: Drosophila melanogaster
• Sequence 2: NP_000504.1
• Gene: OPN1MW / 2652
• HGNCID: 4206
• Length: 364
• Species: Homo sapiens
• Alignment Length: 361
• Identity: 90/361 - (24%)
• Similarity: 165/361 - (45%)
• Gaps: 68/361 - (18%)

  Fly    42 RGFREAPIY-------YH-AGFYIAFIVLMLSSIFGNGLVIWIFSTSKSLRTPSNLLILNLAIFD 98
            ||..|.|.|       || ...::.|:|  ::|:|.||||:......|.||.|.|.:::|||:.|
Human    37 RGPFEGPNYHIAPRWVYHLTSVWMIFVV--IASVFTNGLVLAATMKFKKLRHPLNWILVNLAVAD 99

  Fly    99 L---FMCTNMPHYLINATVGYIVGGDLGCDIYALNG------GISGMGASITNAFIAFDRYKTIS 154
            |   .:.:.:.  ::|...||.|   ||..:..|.|      ||:|:.:.   |.|:::|:..:.
Human   100 LAETVIASTIS--VVNQVYGYFV---LGHPMCVLEGYTVSLCGITGLWSL---AIISWERWMVVC 156

  Fly   155 NP-----IDGRLSYGQIVLLILFTWLWATPFSVLPLFQIWGRYQPEGFLTTCSFDYLTNTDEN-- 212
            .|     .|.:|:    ::.|.|:|:||..::..|:|. |.||.|.|..|:|..|..:.:...
Human   157 KPFGNVRFDAKLA----IVGIAFSWIWAAVWTAPPIFG-WSRYWPHGLKTSCGPDVFSGSSYPGV 216

  Fly   213 RLFVRTIFVWSYVIPMTMILVSYYKLFTHVRVHEKMLAEQAKKMNVKSLSANANADNMSVELRIA 277
            :.::..:.|...:.|:::|::.|.:::..:|.    :|:|.|:          :......|..:.
Human   217 QSYMIVLMVTCCITPLSIIVLCYLQVWLAIRA----VAKQQKE----------SESTQKAEKEVT 267

  Fly   278 KAALIIYMLFILAWTPYSVVALIGCFGEQQLITPF---VSMLPCLACKSVSCLDPWVYATSHPKY 339
            :..:::.:.|...|.||   |...||.......||   ::.||....||.:..:|.:|...:.::
Human   268 RMVVVMVLAFCFCWGPY---AFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYVFMNRQF 329

  Fly   340 R---LELERRLPWLGIREKHATSGTSGGQESVASVS 372
            |   |:|      .|.:....:..:|..:..|:|||
Human   330 RNCILQL------FGKKVDDGSELSSASKTEVSSVS 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rh5	NP_477096.1	7tmA_photoreceptors_insect	54..343	CDD:320207	76/310 (25%)
		TM helix 1	54..80	CDD:320207	8/25 (32%)
		TM helix 2	87..112	CDD:320207	6/27 (22%)
		TM helix 3	124..154	CDD:320207	8/35 (23%)
		TM helix 4	164..184	CDD:320207	5/19 (26%)
		TM helix 5	212..241	CDD:320207	4/30 (13%)
		TM helix 6	271..301	CDD:320207	6/29 (21%)
		TM helix 7	311..336	CDD:320207	8/27 (30%)
OPN1MW	NP_000504.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000269|PubMed:30948514	17..43		3/5 (60%)
		7tm_GPCRs	42..333	CDD:475119	79/322 (25%)
		TM helix 1	56..80	CDD:410628	8/25 (32%)
		TM helix 2	89..111	CDD:410628	6/23 (26%)
		TM helix 3	127..149	CDD:410628	7/24 (29%)
		TM helix 4	171..187	CDD:410628	5/15 (33%)
		TM helix 5	217..240	CDD:410628	3/22 (14%)
		TM helix 6	267..289	CDD:410628	5/24 (21%)
		TM helix 7	301..326	CDD:410628	6/24 (25%)