DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh5 and RRH

DIOPT Version :9

Sequence 1:	NP_001285859.1	Gene:	Rh5 / 34615	FlyBaseID:	FBgn0014019	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_006574.1	Gene:	RRH / 10692	HGNCID:	10450	Length:	337	Species:	Homo sapiens

Alignment Length:	334	Identity:	83/334 - (24%)
Similarity:	156/334 - (46%)	Gaps:	59/334 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DGSVFPMGHGYPAEYQHMVHAHWRGFREAPIYYHAGFYIAFIVLMLSSIFGNGLVIWIFSTSKSL 83
            |||||       ::.:|.:.|.:                 .|:..:.||..|.:|:.||...|.|
Human    16 DGSVF-------SQTEHNIVATY-----------------LIMAGMISIISNIIVLGIFIKYKEL 56

  Fly    84 RTPSNLLILNLAIFDLFMCTNMPHYLINATVGYIVG-----------GDLGCDIYALNGGISGMG 137
            |||:|.:|:|||:.|:.:          :::||.:.           |..||.:||......||.
Human    57 RTPTNAIIINLAVTDIGV----------SSIGYPMSAASDLYGSWKFGYAGCQVYAGLNIFFGMA 111

  Fly   138 ASITNAFIAFDRYKTISNP-IDGRLSYGQIVLLILFTWLWATPFSVLPLFQIWGRYQPEGFLTTC 201
            :......:|.|||.||..| :..|::....:.|||..|:....::::|:.. |..|.|:....||
Human   112 SIGLLTVVAVDRYLTICLPDVGRRMTTNTYIGLILGAWINGLFWALMPIIG-WASYAPDPTGATC 175

  Fly   202 SFDYLTNTDENRLFVRTIFVWSYVIPMTMILVSYYKLFTHVRVHEKMLAEQAKKMNVKSLSANAN 266
            :.::..|......:..|:...::::|:|::...||.:...::.|           .....:.:.|
Human   176 TINWRKNDRSFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHH-----------TTSDCTESLN 229

  Fly   267 ADNMSVELRIAKAALIIYMLFILAWTPYSVVALIGCFGEQQLITPFVSMLPCLACKSVSCLDPWV 331
            .| .|.::.:.|.::|:..:|::||:|||:|.|...||:.:.|.|.::::..|..||.:..:|.:
Human   230 RD-WSDQIDVTKMSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCI 293

  Fly   332 YATSHPKYR 340
            |..::.|:|
Human   294 YVVANKKFR 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh5	NP_001285859.1	7tm_4	60..>236	CDD:304433	49/187 (26%)
Rh5	NP_001285859.1	7tm_1	69..332	CDD:278431	70/274 (26%)
RRH	NP_006574.1	7tmA_Peropsin	26..305	CDD:320201	77/317 (24%)
		TM helix 1	27..53	CDD:320201	8/42 (19%)
		TM helix 2	60..87	CDD:320201	8/36 (22%)
		TM helix 3	98..128	CDD:320201	10/29 (34%)
		TM helix 4	141..159	CDD:320201	4/17 (24%)
		TM helix 5	186..216	CDD:320201	5/29 (17%)
		TM helix 6	233..263	CDD:320201	11/29 (38%)
		TM helix 7	273..298	CDD:320201	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48050
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920