DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh5 and rho

DIOPT Version :9

Sequence 1:	NP_001285859.1	Gene:	Rh5 / 34615	FlyBaseID:	FBgn0014019	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001090803.1	Gene:	rho / 100037900	XenbaseID:	XB-GENE-966887	Length:	354	Species:	Xenopus tropicalis

Alignment Length:	396	Identity:	99/396 - (25%)
Similarity:	164/396 - (41%)	Gaps:	64/396 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 INGPSGPQAYVNDSLGDGSVFPMGHGYPAEY-QHMVHAHWRGFREAPIYYHAGFYIAFIVLMLSS 66
            :||..||..|:..|...|.|     ..|.:| |:.:...|:       |.....|:..::|:...
Frog     1 MNGTEGPNFYIPMSNKTGVV-----RSPFDYPQYYLAEPWK-------YSALAAYMFLLILLGFP 53

  Fly    67 IFGNGLVIWIFSTSKSLRTPSNLLILNLAIFDLFMCTNMPHYLINATV-------GYIVGGDLGC 124
            |  |.:.:::....|.||||.|.::|||...:.||      .|...||       ||.:.|..||
Frog    54 I--NFMTLYVTIQHKKLRTPLNYILLNLVFANHFM------VLCGFTVTMYTSMHGYFIFGQTGC 110

  Fly   125 DIYALNGGISGMGASITNAFIAFDRYKTISNPI-DGRLSYGQIVLLILFTWLWATPFSVLPLFQI 188
            .|......:.|..|..:...:|.:||..:..|: :.|......::.::|||:.|...:..|||.
Frog   111 YIEGFFATLGGEMALWSLVVLAIERYVVVCKPMANFRFGENHAIMGVVFTWIMALSCAAPPLFG- 174

  Fly   189 WGRYQPEGFLTTCSFDYLTNTDE--NRLFVRTIFVWSYVIPMTMILVSYYKLFTHVRVHEKMLAE 251
            |.||.|||...:|..||.|...|  |..||..:|:..:.||:.:|...|.:|...|:   :..|:
Frog   175 WSRYIPEGMQCSCGVDYYTLKPEVNNESFVVYMFIVHFTIPLCVIFFCYGRLLCTVK---EAAAQ 236

  Fly   252 QAKKMNVKSLSANANADNMSVELRIAKAALIIYMLFILAWTPYSVVALIGCFGEQQLITPFVSML 316
            |.:           :|.....|..:.:..:::.:.|::.|.||:.||......:.....|....:
Frog   237 QQE-----------SATTQKAEKEVTRMVVMMVIFFLICWVPYAYVAFYIFTHQGSDFGPVFMTV 290

  Fly   317 PCLACKSVSCLDPWVYATSHPKYRLELERRL-----PWLGIREKHATSGTSGGQESVASVSGDTL 376
            |....||.:..:|.:|...:.::|..|...|     |:             |.:|..::.|..|.
Frog   291 PAFFAKSSAIYNPVIYIVLNKQFRNCLITTLCCGKNPF-------------GDEEGSSAASSKTE 342

  Fly   377 ALSVQN 382
            |.||.:
Frog   343 ASSVSS 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh5	NP_001285859.1	7tm_4	60..>236	CDD:304433	55/185 (30%)
Rh5	NP_001285859.1	7tm_1	69..332	CDD:278431	71/272 (26%)
rho	NP_001090803.1	Rhodopsin_N	3..37	CDD:313611	11/45 (24%)
		7tmA_MWS_opsin	38..317	CDD:381742	76/301 (25%)
		TM helix 1	39..65	CDD:381742	4/27 (15%)
		TM helix 2	72..99	CDD:381742	9/32 (28%)
		TM helix 3	110..140	CDD:381742	7/29 (24%)
		TM helix 4	151..173	CDD:381742	5/21 (24%)
		TM helix 5	200..230	CDD:381742	9/29 (31%)
		TM helix 6	245..275	CDD:381742	7/29 (24%)
		TM helix 7	285..310	CDD:381742	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910