DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hacd1 and HACD1

DIOPT Version :9

Sequence 1:	NP_609534.1	Gene:	Hacd1 / 34614	FlyBaseID:	FBgn0032394	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_055056.3	Gene:	HACD1 / 9200	HGNCID:	9639	Length:	288	Species:	Homo sapiens

Alignment Length:	233	Identity:	78/233 - (33%)
Similarity:	133/233 - (57%)	Gaps:	4/233 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SAKAVSKSSKPGASKEPSAVTKLYLFAYNAGQVVGWSYILWQLVNYYILQGPEFRAQVTLWEYTR 66
            :::|......||..:....:...:|..|:.....||..:...:|.:|:.:|    ....|::..:
Human    52 ASEAGEDREAPGERRRLGVLATAWLTFYDIAMTAGWLVLAIAMVRFYMEKG----THRGLYKSIQ 112

  Fly    67 LAVIIFQNAAFVEILNASFGLVKSNPVVTGFQVFSRMMVVVGVVMATPTGKVSPGLPIALLAWAI 131
            ..:..||..|.:||::...|:|.::.:|||.||.||:.:|..:..:....:....:.:.|:||.:
Human   113 KTLKFFQTFALLEIVHCLIGIVPTSVIVTGVQVSSRIFMVWLITHSIKPIQNEESVVLFLVAWTV 177

  Fly   132 TEIIRYGYYALNIVKVVPHFVVFLRYTTFIVLYPIGVTGELLCFWWAQSYARENSVWSVVMPNKW 196
            |||.||.:|..:::..:|:|:.:.||..||:|||:||.||||..:.|..:.::..::|:.:|||:
Human   178 TEITRYSFYTFSLLDHLPYFIKWARYNFFIILYPVGVAGELLTIYAALPHVKKTGMFSIRLPNKY 242

  Fly   197 NATFSYFGFLWIVMLGYIPIFPQLYLHMFAQRRKILGG 234
            |.:|.|:.||.|.|..|||:|||||.||..||||:|.|
Human   243 NVSFDYYYFLLITMASYIPLFPQLYFHMLRQRRKVLHG 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hacd1	NP_609534.1	PTPLA	73..232	CDD:282269	64/158 (41%)
HACD1	NP_055056.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		1/10 (10%)
HACD1	NP_055056.3	PTPLA	119..278	CDD:282269	64/158 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151776
Domainoid	1	1.000	155	1.000	Domainoid score	I4218
eggNOG	1	0.900	-	-		E1_COG5198
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I4095
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54207
OrthoDB	1	1.010	-	-		D1458293at2759
OrthoFinder	1	1.000	-	-		FOG0001899
OrthoInspector	1	1.000	-	-		otm41099
orthoMCL	1	0.900	-	-		OOG6_101538
Panther	1	1.100	-	-	O	PTHR11035
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R545
SonicParanoid	1	1.000	-	-		X1253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800