DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hacd1 and HACD3

DIOPT Version :9

Sequence 1:	NP_609534.1	Gene:	Hacd1 / 34614	FlyBaseID:	FBgn0032394	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_057479.2	Gene:	HACD3 / 51495	HGNCID:	24175	Length:	362	Species:	Homo sapiens

Alignment Length:	259	Identity:	70/259 - (27%)
Similarity:	117/259 - (45%)	Gaps:	36/259 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKAVSKSSKPGASKE--PSAVTKL---YLFAYNAGQVVGWSYILWQLVNYYILQGPEFRAQVT 60
            :.||...:.:|.....|  |..:|.|   |||.||..|.:|:|:|...|...:.:.|.|     :
Human   120 LRAKEEERLNKLRLESEGSPETLTNLRKGYLFMYNLVQFLGFSWIFVNLTVRFCILGKE-----S 179

  Fly    61 LWE--YTRLAVIIF-QNAAFVEILNASFGLVKSNPVVTGFQVFSR---MMVVVGVVMATPTGKVS 119
            .::  :|...::.| |..|.||.:||:.|:..|..:.:..|:..|   :.::.|.:.......|
Human   180 FYDTFHTVADMMYFCQMLAVVETINAAIGVTTSPVLPSLIQLLGRNFILFIIFGTMEEMQNKAV- 243

  Fly   120 PGLPIALLAWAITEIIRYGYYALNIVKVVPHFVVFLRYTTFIVLYPIGVTGELLCFWWAQSYARE 184
              :......|:..||.||.:|.|..:.:....:.:||||.:|.|||:|...|.:....:.....|
Human   244 --VFFVFYLWSAIEIFRYSFYMLTCIDMDWKVLTWLRYTLWIPLYPLGCLAEAVSVIQSIPIFNE 306

  Fly   185 NSVWSVVMPN--KWNATFSYFGFLWIVMLGYIPIFPQLYL---HMFAQRRKILGGGSSGSPQKK 243
            ...:|..:|.  |....||:|..::::|     ||..||:   |::.|||:..|       |||
Human   307 TGRFSFTLPYPVKIKVRFSFFLQIYLIM-----IFLGLYINFRHLYKQRRRRYG-------QKK 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hacd1	NP_609534.1	PTPLA	73..232	CDD:282269	45/166 (27%)
HACD3	NP_057479.2	p23_hB-ind1_like	8..115	CDD:107222
HACD3	NP_057479.2	PTPLA	195..355	CDD:309504	45/167 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5198
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1458293at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.780