DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hacd1 and HACD2

DIOPT Version :9

Sequence 1:	NP_609534.1	Gene:	Hacd1 / 34614	FlyBaseID:	FBgn0032394	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_001316712.1	Gene:	HACD2 / 201562	HGNCID:	9640	Length:	277	Species:	Homo sapiens

Alignment Length:	268	Identity:	90/268 - (33%)
Similarity:	139/268 - (51%)	Gaps:	40/268 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKAVSKSSKPGA-------------SKEPSAVTKLYLFAYNAGQVVGWSYILWQLVNYYILQG 52
            ::|.|.:|.:..|.             .|.|..:...||..||.....||..|...||..|:.:|
Human     4 VAATAAAKGNGGGGGRAGAGDASGTRKKKGPGPLATAYLVIYNVVMTAGWLVIAVGLVRAYLAKG 68

  Fly    53 PEFRAQVTLWEYTRLAVIIFQNAAFVE-----------------------ILNASFGLVKSNPVV 94
                :..:|:......:..||..|.:|                       ||:.:.|:|.|:.|:
Human    69 ----SYHSLYYSIEKPLKFFQTGALLENLGQYSSHKLQRSKFGVKTIRLPILHCAIGIVPSSVVL 129

  Fly    95 TGFQVFSRMMVVVGVVMATPTGKVSPGLPIALLAWAITEIIRYGYYALNIVKVVPHFVVFLRYTT 159
            |.|||.||:.::..|..:....:....:.:.::||.|||||||.:|..:::..:|:.:.:.|||.
Human   130 TSFQVMSRVFLIWAVTHSVKEVQSEDSVLLFVIAWTITEIIRYSFYTFSLLNHLPYLIKWARYTL 194

  Fly   160 FIVLYPIGVTGELLCFWWAQSYARENSVWSVVMPNKWNATFSYFGFLWIVMLGYIPIFPQLYLHM 224
            ||||||:||:||||..:.|..:.|:..::|:.:|||:|.:|.|:.||.::|:.|||||||||.||
Human   195 FIVLYPMGVSGELLTIYAALPFVRQAGLYSISLPNKYNFSFDYYAFLILIMISYIPIFPQLYFHM 259

  Fly   225 FAQRRKIL 232
            ..||||||
Human   260 IHQRRKIL 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hacd1	NP_609534.1	PTPLA	73..232	CDD:282269	69/181 (38%)
HACD2	NP_001316712.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151775
Domainoid	1	1.000	155	1.000	Domainoid score	I4218
eggNOG	1	0.900	-	-		E1_COG5198
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23409
Inparanoid	1	1.050	172	1.000	Inparanoid score	I4095
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54207
OrthoDB	1	1.010	-	-		D1458293at2759
OrthoFinder	1	1.000	-	-		FOG0001899
OrthoInspector	1	1.000	-	-		otm41099
orthoMCL	1	0.900	-	-		OOG6_101538
Panther	1	1.100	-	-	LDO	PTHR11035
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R545
SonicParanoid	1	1.000	-	-		X1253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800