DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nfs1 and NFS1

DIOPT Version :9

Sequence 1:	NP_609533.1	Gene:	Nfs1 / 34613	FlyBaseID:	FBgn0032393	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_009912.2	Gene:	NFS1 / 850343	SGDID:	S000000522	Length:	497	Species:	Saccharomyces cerevisiae

Alignment Length:	455	Identity:	277/455 - (60%)
Similarity:	333/455 - (73%)	Gaps:	12/455 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IQAQVLRSRATNALANVVRHEATSSRTAAKPAATSKEFRERQVRFNIKNEQTEGRPLYLDAQATT 72
            |||......:..|.|:....:|.   .|:...|.|..::|        |.....||:|||.||||
Yeast    55 IQAAAKAQASARASASGTTPDAV---VASGSTAMSHAYQE--------NTGFGTRPIYLDMQATT 108

  Fly    73 PMDPRVLDAMLPYLTNFYGNPHSRTHAYGWETESAVEKAREQVATLIGADPKEIIFTSGATESNN 137
            |.||||||.||.:.|..||||||.||:|||||.:|||.||..||.:|.|||||||||||||||||
Yeast   109 PTDPRVLDTMLKFYTGLYGNPHSNTHSYGWETNTAVENARAHVAKMINADPKEIIFTSGATESNN 173

  Fly   138 IAVKGVARFYGTKKRHVITTQTEHKCVLDSCRALENEGFKVTYLPVLANGLIDLQQLEETITSET 202
            :.:|||.|||...|:|:|||:|||||||::.||:..|||:||:|.|...|||||::||:.|..:|
Yeast   174 MVLKGVPRFYKKTKKHIITTRTEHKCVLEAARAMMKEGFEVTFLNVDDQGLIDLKELEDAIRPDT 238

  Fly   203 SLVSIMTVNNEIGVRQPVDEIGKLCRSRRVFFHTDAAQAVGKVPLDVNAMNIDLMSISGHKIYGP 267
            .|||:|.|||||||.||:.|||.:||..:::||||||||.||:.:|||.|||||:|||.||||||
Yeast   239 CLVSVMAVNNEIGVIQPIKEIGAICRKNKIYFHTDAAQAYGKIHIDVNEMNIDLLSISSHKIYGP 303

  Fly   268 KGVGALYVRRRPRVRLEPIQSGGGQERGLRSGTVPAPLAVGLGAAAELSLREMDYDKKWVDFLSN 332
            ||:||:||||||||||||:.|||||||||||||:..||..|.|.||.|..:|.|.|:..:..||:
Yeast   304 KGIGAIYVRRRPRVRLEPLLSGGGQERGLRSGTLAPPLVAGFGEAARLMKKEFDNDQAHIKRLSD 368

  Fly   333 RLLDRISSALPHVIRNGDAKATYNGCLNLSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVL 397
            :|:..:.|| .|...||.....|.||:|:||||||||||||||:|:|||||||||||||||||||
Yeast   369 KLVKGLLSA-EHTTLNGSPDHRYPGCVNVSFAYVEGESLLMALRDIALSSGSACTSASLEPSYVL 432

  Fly   398 RAIGTDEDLAHSSIRFGIGRFTTVEEVDYTADKCIKHVERLREMSPLWEMVQEGIDLKTIQWSQH 462
            .|:|.|:.|||||||||||||:|.|||||........|:.|||:|||||||||||||.:|:||.|
Yeast   433 HALGKDDALAHSSIRFGIGRFSTEEEVDYVVKAVSDRVKFLRELSPLWEMVQEGIDLNSIKWSGH 497

Fly 463 462
Yeast 498 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nfs1	NP_609533.1	AAT_I	63..462	CDD:388495	264/398 (66%)
NFS1	NP_009912.2	AAT_I	99..497	CDD:418510	264/398 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346265
Domainoid	1	1.000	492	1.000	Domainoid score	I54
eggNOG	1	0.900	-	-		E1_COG1104
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5463
Inparanoid	1	1.050	537	1.000	Inparanoid score	I177
Isobase	1	0.950	-	0	Normalized mean entropy	S182
OMA	1	1.010	-	-		QHG61832
OrthoFinder	1	1.000	-	-		FOG0003620
OrthoInspector	1	1.000	-	-		oto99800
orthoMCL	1	0.900	-	-		OOG6_100745
Panther	1	1.100	-	-	LDO	PTHR11601
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R807
SonicParanoid	1	1.000	-	-		X2974
TreeFam	1	0.960	-	-
	16	15.740