DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nfs1 and Nfs1

DIOPT Version :9

Sequence 1:	NP_609533.1	Gene:	Nfs1 / 34613	FlyBaseID:	FBgn0032393	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_445914.2	Gene:	Nfs1 / 84594	RGDID:	620912	Length:	459	Species:	Rattus norvegicus

Alignment Length:	442	Identity:	319/442 - (72%)
Similarity:	374/442 - (84%)	Gaps:	15/442 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 AKPAATSKEFRE-----RQVRFNIKNEQTEG----------RPLYLDAQATTPMDPRVLDAMLPY 85
            |..||||...|.     |.:|..:.:.....          ||||:|.|||||:|||||||||||
  Rat    18 ASLAATSVALRRSSVPTRGLRLRVVDHAPHSAVPSEAEAVLRPLYMDVQATTPLDPRVLDAMLPY 82

  Fly    86 LTNFYGNPHSRTHAYGWETESAVEKAREQVATLIGADPKEIIFTSGATESNNIAVKGVARFYGTK 150
            |.|:||||||||||||||:|:|:|:||:|||:||||||:|||||||||||||||:|||||||.::
  Rat    83 LVNYYGNPHSRTHAYGWESEAAMERARQQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSR 147

  Fly   151 KRHVITTQTEHKCVLDSCRALENEGFKVTYLPVLANGLIDLQQLEETITSETSLVSIMTVNNEIG 215
            |:|::||||||||||||||:||.|||:||||||..:|:|||::||..|..:|||||:||||||||
  Rat   148 KKHLVTTQTEHKCVLDSCRSLEAEGFRVTYLPVQKSGIIDLKELEAAIQPDTSLVSVMTVNNEIG 212

  Fly   216 VRQPVDEIGKLCRSRRVFFHTDAAQAVGKVPLDVNAMNIDLMSISGHKIYGPKGVGALYVRRRPR 280
            |:||:.|||::|.||:::|||||||||||:|||||.|.||||||||||:||||||||:|:|||||
  Rat   213 VKQPIAEIGQICSSRKLYFHTDAAQAVGKIPLDVNDMKIDLMSISGHKLYGPKGVGAIYIRRRPR 277

  Fly   281 VRLEPIQSGGGQERGLRSGTVPAPLAVGLGAAAELSLREMDYDKKWVDFLSNRLLDRISSALPHV 345
            ||:|.:|||||||||:||||||.||.||||||.||:.:||:||.|.:..|:.||:.:|...||.|
  Rat   278 VRVEALQSGGGQERGMRSGTVPTPLVVGLGAACELAQQEMEYDHKRISKLAERLIQKIMKNLPDV 342

  Fly   346 IRNGDAKATYNGCLNLSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHSS 410
            :.|||.|..|.||:|||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   343 VMNGDPKQHYPGCINLSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHSS 407

  Fly   411 IRFGIGRFTTVEEVDYTADKCIKHVERLREMSPLWEMVQEGIDLKTIQWSQH 462
            ||||||||||.||||||..|||.||:|||||||||||||:|||||:|:|:||
  Rat   408 IRFGIGRFTTEEEVDYTVQKCIHHVKRLREMSPLWEMVQDGIDLKSIKWTQH 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nfs1	NP_609533.1	AAT_I	63..462	CDD:388495	308/398 (77%)
Nfs1	NP_445914.2	PRK14012	60..459	CDD:184450	298/385 (77%)
Nfs1	NP_445914.2	Aminotran_5	62..423	CDD:278684	277/360 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353221
Domainoid	1	1.000	582	1.000	Domainoid score	I199
eggNOG	1	0.900	-	-		E1_COG1104
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5463
Inparanoid	1	1.050	651	1.000	Inparanoid score	I753
OMA	1	1.010	-	-		QHG61832
OrthoDB	1	1.010	-	-		D287160at33208
OrthoFinder	1	1.000	-	-		FOG0003620
OrthoInspector	1	1.000	-	-		oto97494
orthoMCL	1	0.900	-	-		OOG6_100745
Panther	1	1.100	-	-	LDO	PTHR11601
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2974
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810