DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nfs1 and nfs1

DIOPT Version :9

Sequence 1:	NP_609533.1	Gene:	Nfs1 / 34613	FlyBaseID:	FBgn0032393	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_001038458.1	Gene:	nfs1 / 562714	ZFINID:	ZDB-GENE-060405-1	Length:	451	Species:	Danio rerio

Alignment Length:	432	Identity:	324/432 - (75%)
Similarity:	371/432 - (85%)	Gaps:	7/432 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SRTAAKPAATSKE-FRERQVRFNIKNEQTEGRPLYLDAQATTPMDPRVLDAMLPYLTNFYGNPHS 95
            :::||......|| .:.|::      |:.|.||||:|.|||||||||||||||||..|:||||||
Zfish    26 AQSAANTVQKQKELIKSREL------EKDELRPLYMDFQATTPMDPRVLDAMLPYQVNYYGNPHS 84

  Fly    96 RTHAYGWETESAVEKAREQVATLIGADPKEIIFTSGATESNNIAVKGVARFYGTKKRHVITTQTE 160
            ||||||||:|||:||||:|||.||||||:||:||||||||||:::|||||||..||.|:||||.|
Zfish    85 RTHAYGWESESAMEKARKQVAGLIGADPREIVFTSGATESNNMSIKGVARFYKAKKMHIITTQIE 149

  Fly   161 HKCVLDSCRALENEGFKVTYLPVLANGLIDLQQLEETITSETSLVSIMTVNNEIGVRQPVDEIGK 225
            |||||||||.||.|||.:|||||.:||||||:|||:||..:|||||||.:||||||:|||.|||.
Zfish   150 HKCVLDSCRVLETEGFDITYLPVKSNGLIDLKQLEDTIRPDTSLVSIMAINNEIGVKQPVKEIGH 214

  Fly   226 LCRSRRVFFHTDAAQAVGKVPLDVNAMNIDLMSISGHKIYGPKGVGALYVRRRPRVRLEPIQSGG 290
            ||||:.|||||||||||||:|:||....:||||||.||||||||||||:|||||||||||:||||
Zfish   215 LCRSKNVFFHTDAAQAVGKIPVDVTDWKVDLMSISAHKIYGPKGVGALFVRRRPRVRLEPLQSGG 279

  Fly   291 GQERGLRSGTVPAPLAVGLGAAAELSLREMDYDKKWVDFLSNRLLDRISSALPHVIRNGDAKATY 355
            ||||||||||||.|||||||||.|::.:|::||.|.|..|:|||:.:|.|.:|.|:.|||....|
Zfish   280 GQERGLRSGTVPTPLAVGLGAACEIAQQELEYDHKRVSLLANRLVQKIMSEIPDVVMNGDPDQRY 344

  Fly   356 NGCLNLSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHSSIRFGIGRFTT 420
            .||:||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||
Zfish   345 PGCINLSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGADEDLAHSSIRFGIGRFTT 409

  Fly   421 VEEVDYTADKCIKHVERLREMSPLWEMVQEGIDLKTIQWSQH 462
            .|||||||:|||..|:|||||||||||||||||||:|:|:||
Zfish   410 EEEVDYTAEKCIHQVKRLREMSPLWEMVQEGIDLKSIKWTQH 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nfs1	NP_609533.1	AAT_I	63..462	CDD:388495	314/398 (79%)
nfs1	NP_001038458.1	PRK14012	52..451	CDD:184450	314/398 (79%)
nfs1	NP_001038458.1	Aminotran_5	54..415	CDD:278684	283/360 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595310
Domainoid	1	1.000	581	1.000	Domainoid score	I203
eggNOG	1	0.900	-	-		E1_COG1104
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5463
Inparanoid	1	1.050	657	1.000	Inparanoid score	I753
OMA	1	1.010	-	-		QHG61832
OrthoDB	1	1.010	-	-		D287160at33208
OrthoFinder	1	1.000	-	-		FOG0003620
OrthoInspector	1	1.000	-	-		oto39327
orthoMCL	1	0.900	-	-		OOG6_100745
Panther	1	1.100	-	-	LDO	PTHR11601
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R807
SonicParanoid	1	1.000	-	-		X2974
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800