DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nfs1 and nfs1

DIOPT Version :9

Sequence 1:	NP_609533.1	Gene:	Nfs1 / 34613	FlyBaseID:	FBgn0032393	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_596002.2	Gene:	nfs1 / 2540403	PomBaseID:	SPBC21D10.11c	Length:	501	Species:	Schizosaccharomyces pombe

Alignment Length:	459	Identity:	275/459 - (59%)
Similarity:	339/459 - (73%)	Gaps:	31/459 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TSSRTAAKPAATSKEFRERQVRFNIKN--------------------EQTEG------RPLYLDA 68
            |||| ..||:.::|   .|:..:.:.|                    .||..      .|:|:|.
pombe    48 TSSR-MDKPSMSNK---PREQMYGLGNMTAVQEPIPENSLKTVTLDQAQTAASTVTGLHPIYMDF 108

  Fly    69 QATTPMDPRVLDAMLPYLTNFYGNPHSRTHAYGWETESAVEKAREQVATLIGADPKEIIFTSGAT 133
            |||:|:|.||||:|||:.|..||||||||||||||.|.|||.||:::|::|.|||:|||||||||
pombe   109 QATSPLDYRVLDSMLPFFTGIYGNPHSRTHAYGWEAEKAVENARQEIASVINADPREIIFTSGAT 173

  Fly   134 ESNNIAVKGVARFYGTKKRHVITTQTEHKCVLDSCRALENEGFKVTYLPVLANGLIDLQQLEETI 198
            ||||..:|||||||.::|:|:::.||||||||||.|||:.|||:||:|||..||||:|.:|.:.|
pombe   174 ESNNAILKGVARFYKSRKKHLVSVQTEHKCVLDSLRALQEEGFEVTFLPVQTNGLINLDELRDAI 238

  Fly   199 TSETSLVSIMTVNNEIGVRQPVDEIGKLCRSRRVFFHTDAAQAVGKVPLDVNAMNIDLMSISGHK 263
            ..:|..||:|.|||||||.||::||||:||.::||||:||||..||:.:|||.|||||||||.||
pombe   239 RPDTVCVSVMAVNNEIGVCQPLEEIGKICRQKKVFFHSDAAQGYGKIDIDVNRMNIDLMSISAHK 303

  Fly   264 IYGPKGVGALYVRRRPRVRLEPIQSGGGQERGLRSGTVPAPLAVGLGAAAELSLREMDYDKKWVD 328
            ||||||:||.||||||||||||:.|||||||||||||:.....||.|.||.:...||.||...:.
pombe   304 IYGPKGIGAAYVRRRPRVRLEPLISGGGQERGLRSGTLAPSQVVGFGTAARICKEEMKYDYAHIS 368

  Fly   329 FLSNRLLDRISSALPHVIRNGDAKATYNGCLNLSFAYVEGESLLMALKDVALSSGSACTSASLEP 393
            .||.||:|.: .|:|:...|||.|:.|.||:|:||.|||||||||.||::|||||||||||||||
pombe   369 KLSQRLIDGL-LAIPYTSLNGDPKSRYPGCVNISFNYVEGESLLMGLKNIALSSGSACTSASLEP 432

  Fly   394 SYVLRAIGTDEDLAHSSIRFGIGRFTTVEEVDYTADKCIKHVERLREMSPLWEMVQEGIDLKTIQ 458
            ||||||||..::.||||||||||||||..|:||..:...:.|..||.|||||::||||:||.||:
pombe   433 SYVLRAIGQSDENAHSSIRFGIGRFTTEAEIDYAIENVSRQVSFLRNMSPLWDLVQEGVDLSTIE 497

  Fly   459 WSQH 462
            ||||
pombe   498 WSQH 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nfs1	NP_609533.1	AAT_I	63..462	CDD:388495	262/398 (66%)
nfs1	NP_596002.2	PRK14012	103..501	CDD:184450	262/398 (66%)
nfs1	NP_596002.2	Aminotran_5	104..465	CDD:278684	241/361 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	501	1.000	Domainoid score	I56
eggNOG	1	0.900	-	-		E1_COG1104
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5463
Inparanoid	1	1.050	550	1.000	Inparanoid score	I196
OMA	1	1.010	-	-		QHG61832
OrthoFinder	1	1.000	-	-		FOG0003620
OrthoInspector	1	1.000	-	-		oto101466
orthoMCL	1	0.900	-	-		OOG6_100745
Panther	1	1.100	-	-	LDO	PTHR11601
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R807
SonicParanoid	1	1.000	-	-		X2974
TreeFam	1	0.960	-	-
	14	13.860