DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment escl and FIE

DIOPT Version :9

Sequence 1:	NP_001285857.1	Gene:	escl / 34611	FlyBaseID:	FBgn0032391	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_188710.1	Gene:	FIE / 821622	AraportID:	AT3G20740	Length:	369	Species:	Arabidopsis thaliana

Alignment Length:	395	Identity:	158/395 - (40%)
Similarity:	229/395 - (57%)	Gaps:	50/395 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 SKSPNTRKLNRLCRRIKAPKMVQPLYKYSSHVREDHNHQIFGVQFNPFLDRGQPQVFATVGKDRV 136
            |.:|:.:|..::..||:..|  :|||               .|.|| |||.....||.|.|.:|:
plant    14 SLTPSNKKSYKVTNRIQEGK--KPLY---------------AVVFN-FLDARFFDVFVTAGGNRI 60

  Fly   137 SIYECERSTGQESCEGIRLLQVYADPDTDESFYTCAWSYDSVTGDPVLAAAGYRGVIRIFNPVKH 201
            ::|.|   .|..:   |..||.|||.|.:|||||.:|:. .|.|:|.:||.|.:|:||:.:....
plant    61 TLYNC---LGDGA---ISALQSYADEDKEESFYTVSWAC-GVNGNPYVAAGGVKGIIRVIDVNSE 118

  Fly   202 QCSKNYIGHGHAINELKFHPTRPQLLLSGSKDHSLRLWNIQSDVCVAVFGGVEGHRDEVLSVDF- 265
            ...|:.:|||.::||::..|.:|||:::.|||.|:||||:::.:|:.:|.|..|||.|||||||
plant   119 TIHKSLVGHGDSVNEIRTQPLKPQLVITASKDESVRLWNVETGICILIFAGAGGHRYEVLSVDFH 183

  Fly   266 --DLRGDRIMSSGMDHSLKLWRLDKPDIKE---AIELSSGFSPNKNTGPFPTIKEHFPDFSTRDI 325
              |:.  |..|.|||.::|:|     .:||   .:|.|  |:...:...|||....||.| |..|
plant   184 PSDIY--RFASCGMDTTIKIW-----SMKEFWTYVEKS--FTWTDDPSKFPTKFVQFPVF-TASI 238

  Fly   326 HRNYVDCVQWFGDFVFSKSCENSIVCWKPGKLSESWHEIKPQESATTVLHHFDYKMCEIWFVRFA 390
            |.|||||.:|||||:.|||.:|.|:.|:| :|.|:    .|.|.|:.||..:...||:|||::|:
plant   239 HTNYVDCNRWFGDFILSKSVDNEILLWEP-QLKEN----SPGEGASDVLLRYPVPMCDIWFIKFS 298

  Fly   391 FNAWQKILALGNQLGTTFVWEL-DCNDPNLTKCSQLVHPKSNSTIRQTSFSKDGSILVCVCDDST 454
            .:.....:|:|||.|..:||:| .|....:||.|   |.:|.|.||||:.|.|||.::..|:|.|
plant   299 CDLHLSSVAIGNQEGKVYVWDLKSCPPVLITKLS---HNQSKSVIRQTAMSVDGSTILACCEDGT 360

  Fly   455 VWRWD 459
            :||||
plant   361 IWRWD 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
escl	NP_001285857.1	WD40	96..459	CDD:225201	149/369 (40%)
		WD40	107..352	CDD:295369	104/250 (42%)
		WD40 repeat	111..158	CDD:293791	16/46 (35%)
		WD40 repeat	169..209	CDD:293791	13/39 (33%)
		WD40 repeat	214..251	CDD:293791	15/36 (42%)
		WD40	253..>459	CDD:295369	90/212 (42%)
		WD40 repeat	261..323	CDD:293791	24/67 (36%)
		WD40 repeat	330..378	CDD:293791	22/47 (47%)
		WD40 repeat	386..426	CDD:293791	14/40 (35%)
		WD40 repeat	434..458	CDD:293791	12/23 (52%)
FIE	NP_188710.1	WD40	50..365	CDD:421866	141/339 (42%)
		WD40 repeat	87..126	CDD:293791	13/39 (33%)
		WD40 repeat	131..168	CDD:293791	15/36 (42%)
		WD40 repeat	178..219	CDD:293791	18/49 (37%)
		WD40 repeat	243..284	CDD:293791	22/45 (49%)
		WD40 repeat	292..332	CDD:293791	15/39 (38%)
		WD40 repeat	339..364	CDD:293791	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	136	1.000	Domainoid score	I1597
eggNOG	1	0.900	-	-		E1_KOG1034
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2814
Inparanoid	1	1.050	273	1.000	Inparanoid score	I905
OMA	1	1.010	-	-		QHG59795
OrthoDB	1	1.010	-	-		D1191277at2759
OrthoFinder	1	1.000	-	-		FOG0005723
OrthoInspector	1	1.000	-	-		otm2719
orthoMCL	1	0.900	-	-		OOG6_102885
Panther	1	1.100	-	-	LDO	PTHR10253
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4715
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840