DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment escl and Lrwd1

DIOPT Version :9

Sequence 1:	NP_001285857.1	Gene:	escl / 34611	FlyBaseID:	FBgn0032391	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_082167.2	Gene:	Lrwd1 / 71735	MGIID:	1918985	Length:	648	Species:	Mus musculus

Alignment Length:	498	Identity:	96/498 - (19%)
Similarity:	165/498 - (33%)	Gaps:	176/498 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 AEAVLSNNSSSVCNVVEPDDEHEVNSVDREDTASLFSTTTTTTR--SKSPNTRKLNRLCRRI--- 87
            ||.::::..:.|.:...|.:..:...      ||.|......::  .|.|.|...::..|.:
Mouse   196 AEELVASGGAQVQDAKVPVEHPQAAG------ASKFRAREVASKRPGKDPVTLPPSKRVRALPPA 254

  Fly    88 ------------KAPKMVQPLYKYSSHVR----EDHNHQIFGVQFNPFLDRGQ----PQVFATVG 132
                        :|...::||:....|.|    :|...|::...|.|..:.|.    .|..||.|
Mouse   255 QAEGSPMGADGGQAALHLEPLHFLQCHSRNNSPKDLETQLWACAFEPAREEGHSRATSQTVATCG 319

  Fly   133 KDRVSIYECERSTGQESCEGIRLLQVYADPDTDESFYTCAWSYDSVTGDP-------VLAAAGYR 190
            .:.|.:.:|:  ||       .:|..|..|  .|.|::.||:..:|....       :|||||.|
Mouse   320 GEAVCVIDCQ--TG-------LVLHKYKVP--GEEFFSVAWTALTVVTQAGHKKRWNMLAAAGLR 373

  Fly   191 GVIRIFNPVKHQCSKNYIGHGHAINELKFHPTRPQLLLSGSKDHSLRLWNIQSDVCVAVFGGVEG 255
            |::|:.:.....|......|..||..|.|.|:....|.:.|.|..:.||:|          ||..
Mouse   374 GMVRLLHVRAGFCCSVIRAHKKAIATLCFSPSHETHLFTASYDKRIILWDI----------GVPN 428

  Fly   256 HRDEVLSVDFDLRGDRIMSSGMDHSLKLWRLDKPDIKEAIELSSGFSPNKNTGPFPTIKEHFPDF 320
            .       |:..:..::::                      |:.|..|.: ..|..|.    ||
Mouse   429 Q-------DYKFQASQLLT----------------------LNCGSVPLR-LCPVATC----PD- 458

  Fly   321 STRDIHRNYVDCVQWFGDFVFSKSCENSIVCWKPGKLSESWHEIKPQESATTVLHHFDYKMCEIW 385
                             ||:.: .||....||.. :|.:      ||:.          ::||:.
Mouse   459 -----------------DFLLA-GCEGGCYCWDV-RLDQ------PQKQ----------RVCEVN 488

  Fly   386 FV-------------RFAFNAWQKILALGNQLGTTFVW---------------------ELDCND 416
            |:             ..||.....:.:.|:..||.::|                     .|..:.
Mouse   489 FIFSEDSKVSGQRVDGLAFVNEDVVASKGSGQGTIYLWSWSQTWAGRGRQSVLPVVILVRLQWSP 553

  Fly   417 PNLTKCSQLVHPKSNSTIRQTSFSKDGSILVCVCDDSTVWRWD 459
            .||...|....|..|             :::|..::.:||.:|
Mouse   554 TNLAYFSLSTCPGKN-------------LVLCGDEEGSVWIYD 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
escl	NP_001285857.1	WD40	96..459	CDD:225201	82/411 (20%)
		WD40	107..352	CDD:295369	55/255 (22%)
		WD40 repeat	111..158	CDD:293791	12/50 (24%)
		WD40 repeat	169..209	CDD:293791	12/46 (26%)
		WD40 repeat	214..251	CDD:293791	10/36 (28%)
		WD40	253..>459	CDD:295369	36/239 (15%)
		WD40 repeat	261..323	CDD:293791	8/61 (13%)
		WD40 repeat	330..378	CDD:293791	9/47 (19%)
		WD40 repeat	386..426	CDD:293791	11/73 (15%)
		WD40 repeat	434..458	CDD:293791	3/23 (13%)
Lrwd1	NP_082167.2	LRR_4	22..64	CDD:289563
		LRR 1	22..43
		leucine-rich repeat	23..48	CDD:275378
		LRR_8	47..103	CDD:290566
		LRR_4	47..87	CDD:289563
		LRR 2	48..69
		leucine-rich repeat	49..70	CDD:275378
		LRR_4	70..108	CDD:289563
		LRR 3	70..91
		leucine-rich repeat	71..92	CDD:275378
		LRR 4	92..113
		leucine-rich repeat	93..106	CDD:275378
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..262		7/53 (13%)
		WD40	295..585	CDD:295369	78/393 (20%)
		WD40 repeat	345..391	CDD:293791	12/45 (27%)
		WD40	<365..585	CDD:225201	59/312 (19%)
		WD 1	392..432		15/56 (27%)
		WD40 repeat	397..440	CDD:293791	13/59 (22%)
		WD 2	443..482		15/69 (22%)
		WD40 repeat	448..490	CDD:293791	15/82 (18%)
		WD 3	497..536		6/38 (16%)
		WD40 repeat	497..526	CDD:293791	5/28 (18%)
		WD 4	541..592		10/56 (18%)
		WD40 repeat	558..598	CDD:293791	7/39 (18%)
		WD 5	616..648
		WD40 repeat	616..645	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8374
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860