Protein Alignment escl and Eed

DIOPT Version :10

• Sequence 1: NP_723702.1
• Gene: escl / 34611
• FlyBaseID: FBgn0032391
• Length: 462
• Species: Drosophila melanogaster
• Sequence 2: NP_068676.1
• Gene: Eed / 13626
• MGIID: 95286
• Length: 441
• Species: Mus musculus
• Alignment Length: 476
• Identity: 245/476 - (51%)
• Similarity: 315/476 - (66%)
• Gaps: 51/476 - (10%)

  Fly     1 MTETNPSEISPPSEEPPAEDESTDHSPAEAVLSNNSSSVCNVVEPDDEHEVNSVDREDTASLFST 65
            |:|...|.....::.|.|:.:.         ||::.:|     .||    ::..:.:|..|:.|.
Mouse     1 MSEREVSTAPAGTDMPAAKKQK---------LSSDENS-----NPD----LSGDENDDAVSIESG 47

  Fly    66 TTT---TTRSKSPNTRKLNRLCRRIKAP--------KMVQPLYKYS----SHVREDHNHQIFGVQ 115
            |.|   .|.:.:||            ||        |......|||    :.::||||..:||||
Mouse    48 TNTERPDTPTNTPN------------APGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQ 100

  Fly   116 FNPFLDRGQPQVFATVGKDRVSIYECERSTGQESCEGIRLLQVYADPDTDESFYTCAWSYDSVTG 180
            ||.....|.|.||||||.:||::||| .|.|:     |||||.|.|.|.||:||||||:|||.|.
Mouse   101 FNWHSKEGDPLVFATVGSNRVTLYEC-HSQGE-----IRLLQSYVDADADENFYTCAWTYDSNTS 159

  Fly   181 DPVLAAAGYRGVIRIFNPVKHQCSKNYIGHGHAINELKFHPTRPQLLLSGSKDHSLRLWNIQSDV 245
            .|:||.||.||:|||.||:..||.|:|:|||:|||||||||..|.||||.||||:|||||||:|.
Mouse   160 HPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDT 224

  Fly   246 CVAVFGGVEGHRDEVLSVDFDLRGDRIMSSGMDHSLKLWRLDKPDIKEAIELSSGFSPNKNTGPF 310
            .||:|||||||||||||.|:||.|::|||.||||||||||::...:..||:.|..::|||...||
Mouse   225 LVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPF 289

  Fly   311 PTIKEHFPDFSTRDIHRNYVDCVQWFGDFVFSKSCENSIVCWKPGKLSESWHEIKPQESATTVLH 375
            .:.|.||||||||||||||||||:|.||.:.||||||:||||||||:.:...:|||.||..|:|.
Mouse   290 ISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILG 354

  Fly   376 HFDYKMCEIWFVRFAFNAWQKILALGNQLGTTFVWELDCNDPNLTKCSQLVHPKSNSTIRQTSFS 440
            .|||..|:||::||:.:.|||:||||||:|..:||:|:..||:..||:.|.|.|..:.|||||||
Mouse   355 RFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFS 419

  Fly   441 KDGSILVCVCDDSTVWRWDRV 461
            :|.|||:.||||:::|||||:
Mouse   420 RDSSILIAVCDDASIWRWDRL 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
escl	NP_723702.1	WD40	102..460	CDD:441893	219/357 (61%)
		WD40 repeat	111..158	CDD:293791	25/46 (54%)
		WD40 repeat	169..209	CDD:293791	25/39 (64%)
		WD40 repeat	214..251	CDD:293791	27/36 (75%)
		WD40 repeat	261..323	CDD:293791	34/61 (56%)
		WD40 repeat	330..378	CDD:293791	28/47 (60%)
		WD40 repeat	386..426	CDD:293791	19/39 (49%)
		WD40 repeat	434..458	CDD:293791	16/23 (70%)
Eed	NP_068676.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..72		20/100 (20%)
		Interaction with EZH2	81..441		222/366 (61%)
		WD40 repeat	96..140	CDD:293791	27/49 (55%)
		WD40	<109..439	CDD:441893	208/335 (62%)
		WD40 repeat	148..188	CDD:293791	25/39 (64%)
		WD40 repeat	193..230	CDD:293791	27/36 (75%)
		WD40 repeat	240..302	CDD:293791	34/61 (56%)
		WD40 repeat	309..357	CDD:293791	28/47 (60%)
		WD40 repeat	365..405	CDD:293791	19/39 (49%)
		WD40 repeat	413..437	CDD:293791	16/23 (70%)