DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zuc and PLD2

DIOPT Version :9

Sequence 1:	NP_609530.1	Gene:	zuc / 34609	FlyBaseID:	FBgn0261266	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_002654.3	Gene:	PLD2 / 5338	HGNCID:	9068	Length:	933	Species:	Homo sapiens

Alignment Length:	155	Identity:	33/155 - (21%)
Similarity:	54/155 - (34%)	Gaps:	47/155 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 WKLVQCSRSKREKASRVHEVIIFNELGEICAAVHMRNSSMGSQ-----KPQVS----PCCNTHCS 89
            |:|....:.|.|:..|| .:::|.|: |:...:   ||....:     .|.:.    |...|..:
Human   381 WRLDIMLKRKAEEGVRV-SILLFKEV-ELALGI---NSGYSKRALMLLHPNIKVMRHPDQVTLWA 440

  Fly    90 LRNVAKIVEQIDRAVYSIDLAI-------YTFTSLFLADSIKRALQRGVIIRIISDGEMVYSKGS 147
            ......:|:|:...:..:|||.       |..|.  |.||.:.|..:....|..|
Human   441 HHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTD--LGDSSESAASQPPTPRPDS---------- 493

  Fly   148 QISMLAQLGVPVRVPITTNLMHNKF 172
                          |.|.:|.||:|
Human   494 --------------PATPDLSHNQF 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zuc	NP_609530.1	PLDc_SF	87..239	CDD:301585	19/93 (20%)
zuc	NP_609530.1	PLDc_2	96..239	CDD:289836	19/84 (23%)
PLD2	NP_002654.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		PX_domain	62..192	CDD:295365
		PLN02866	66..918	CDD:215467	33/155 (21%)
		PH_PLD	180..309	CDD:269956
		PLDc_SF	335..475	CDD:301585	21/100 (21%)
		Catalytic	441..788		19/90 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..497		6/43 (14%)
		PLDc_vPLD2_2	614..795	CDD:197303
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1502
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900