DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6686 and SART1

DIOPT Version :9

Sequence 1:	NP_723700.1	Gene:	CG6686 / 34608	FlyBaseID:	FBgn0032388	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_005137.1	Gene:	SART1 / 9092	HGNCID:	10538	Length:	800	Species:	Homo sapiens

Alignment Length:	836	Identity:	324/836 - (38%)
Similarity:	459/836 - (54%)	Gaps:	151/836 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 PPQISKHAEYE-----------SRREREIER--ERDARKRSGRERERERNRERSRSQSPASSSRK 254
            ||:..:|.:::           .||:|..||  ||.:.:|......|.....|.|||:..|..|.
Human    29 PPRHREHKKHKHRSGGSGGSGGERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRV 93

  Fly   255 PATKEREPSSRSFSPIPENGAGDVLSITETNKLRAKLGLKPLEVDSGPSKAGPPPGSSSQGEIKK 319
            ...|..:....:.|....:|....|||.||||||||||||||||::...:||          .|:
Human    94 KREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAIKKEAG----------TKE 148

  Fly   320 PHGEADLSSYKDEWGEFLHKPADNLKEKREAEKLREKLKQRKEKRFLEERLARIKTLGESDEETD 384
            ....||:.               |....|:.|:|||||...||||.|.::|.:||||||.|...|
Human   149 EPVTADVI---------------NPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLD 198

  Fly   385 NVSKWVDKNKRVVNEREEAMRKAKELEELDEAFGVSEILEQEKTKARQRAYGDSNLKGLRVDHDM 449
            :.:.|:::::::..|::.|.::||.|||:|:.||||.::|:|..:.||..|...:|:||.|:|.:
Human   199 DTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAI 263

  Fly   450 DDFGEGRTVILTLKDQDVLNEEEGDTLVNVNMVDEERYKKNVANKKQNP--LSYGYNVYEEQYDE 512
            |.|.||.|:||||||:.||.||| |.|||||:||:||.:|||..:|:.|  |.|   ..:|..|:
Human   264 DSFREGETMILTLKDKGVLQEEE-DVLVNVNLVDKERAEKNVELRKKKPDYLPY---AEDESVDD 324

  Fly   513 LGNPIERSVLEKYDDEMEGQPKKRKNFVIGENMDEEREHRRKLLEIKTKLAGKRL--ETLEDTNL 575
            |.....||:|.|||:|:||:.........|...|..||  |:|.||:.||   ||  ::|.....
Human   325 LAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLRE--RELEEIRAKL---RLQAQSLSTVGP 384

  Fly   576 QLASDTYSAEELAKFKKPKKKVKKLRQK-----LKAEDLAPLAMGEASGSSDFGSR---GGRYRD 632
            :|||:..:.||:..|||.|::|||:|:|     ::|:||.||  |:.:...|||||   .||.|.
Human   385 RLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPL--GDQTQDGDFGSRLRGRGRRRV 447

  Fly   633 HEDAEMEEFKPQ------IKVE--------------------VEDD----DLERVLAKARKLKQK 667
            .|..|.:|..||      .:||                    :|:|    :|::.|.|.|:|:|.
Human   448 SEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQL 512

  Fly   668 E-------------NIIKKPLPVDFESIQR----EIKPEHVEDTASGVVLTGVDGNIVLNATAEF 715
            :             .|:||     .||.||    :..||.             .|.||.|||:||
Human   513 QQLQQLRDSGEKVVEIVKK-----LESRQRGWEEDEDPER-------------KGAIVFNATSEF 559

  Fly   716 CRTLGDIPTYGMAGNRNEDSNDMMDFDKTEQPEEHMETHTD-EPALSHGTWNSVNPDEVMQPADL 779
            |||||:|||||:|||| |:..::|||::.|:...:..:.:| |..:.   |::||.||..|..|.
Human   560 CRTLGEIPTYGLAGNR-EEQEELMDFERDEERSANGGSESDGEENIG---WSTVNLDEEKQQQDF 620

  Fly   780 DNLGEDLEDRAILDEEPDVGAGVANALRLALSKGYLEKEEKNRPSNTKMAHLQAKN-------YS 837
                 ......||||||.|..|:|.||.|..:||.||...:      |:|.::|.|       |.
Human   621 -----SASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQ------KVARVKAPNKSLPSAVYC 674

  Fly   838 IEDKAAGEDEKVGRRDRFHFGPITDFKDKETFKPNVKLDYIDDNGRILNLKEAFRYLSHKFHGKG 902
            ||||.| .|:|..||:.:. |...|||:|:.:||:||::|:|:.||.|..|||||.|||:|||||
Human   675 IEDKMA-IDDKYSRREEYR-GFTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKG 737

  Fly   903 PGKNKIEKRLKKMEQDGLMKTMSSTDTPLGTLTMLQQKQKETKTAYVVLSGNNKNV 958
            .||.|.|:|:||::::.|:|.|||:||||||:.:||:|||..||.|:||||:.|::
Human   738 SGKMKTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQKTPYIVLSGSGKSM 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6686	NP_723700.1	SART-1	279..918	CDD:281354	279/705 (40%)
SART1	NP_005137.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..120		22/90 (24%)
		SART-1	117..753	CDD:397428	279/706 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..330		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..497		23/79 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	571..604		11/33 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158244
Domainoid	1	1.000	386	1.000	Domainoid score	I810
eggNOG	1	0.900	-	-		E1_KOG2217
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1594
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55038
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003739
OrthoInspector	1	1.000	-	-		oto89993
orthoMCL	1	0.900	-	-		OOG6_103596
Panther	1	1.100	-	-	LDO	PTHR14152
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1368
SonicParanoid	1	1.000	-	-		X4756
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790