DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6686 and DOT2

DIOPT Version :9

Sequence 1:	NP_723700.1	Gene:	CG6686 / 34608	FlyBaseID:	FBgn0032388	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_001318573.1	Gene:	DOT2 / 831541	AraportID:	AT5G16780	Length:	820	Species:	Arabidopsis thaliana

Alignment Length:	970	Identity:	261/970 - (26%)
Similarity:	424/970 - (43%)	Gaps:	264/970 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 ERERANEVISLEESDSDSFSFFSGSDCVEVPVQAQVQAQAKLRDARESSNRDKERDSGRDRELLR 131
            |:.::...|..|.:|      :.||     ||:.....:.|.:|.|   ::|||:|  .|||.:|
plant     4 EKSKSRHEIREERAD------YEGS-----PVREHRDGRRKEKDHR---SKDKEKD--YDREKIR 52

  Fly   132 ERERERDRERERDRDREKEREREREKERLREREEREREREKERIREREKERLRERERERERERVR 196
            :::..||:|:||||.|.::.:.|:|..|     .|::||||::.|:|.||:.:|:||.|.::|
plant    53 DKDHRRDKEKERDRKRSRDEDTEKEISR-----GRDKEREKDKSRDRVKEKDKEKERNRHKDR-- 110

  Fly   197 ELTAPPPPQISKHAEYESRREREIERERDARKRSGRERERERNRERSRSQSPASSSRKPATKERE 261
                                    |.|||..|...::|.|.:.|...:|......:.|.|.:...
plant   111 ------------------------ENERDNEKEKDKDRARVKERASKKSHEDDDETHKAAERYEH 151

  Fly   262 PSSRSFSPIPENGAGDVLSITETNKLRAKLGLKPLEVDSGPSKAGPPPGSSSQGEIKKPHGEADL 326
            ..:|..     |..||                   .||           ::|.|
plant   152 SDNRGL-----NEGGD-------------------NVD-----------AASSG----------- 170

  Fly   327 SSYKDEWGEFLHKPADNLKEKREAEKLREKLKQRKEKRFLEERLARIKTLGESDEETDNVSKWVD 391
                        |.|..|..:....|:||   :||:|.                |:..:...||.
plant   171 ------------KEASALDLQNRILKMRE---ERKKKA----------------EDASDALSWVA 204

  Fly   392 KNKRVVNEREEAMRKAKELEELDEAFGVSEILEQEKTKARQRAYGD--SNLKGLRVDHDMDDFGE 454
            :::::..:|....::|::|..:.|        ||:.....:...|:  .:|.|::|.|.::...|
plant   205 RSRKIEEKRNAEKQRAQQLSRIFE--------EQDNLNQGENEDGEDGEHLSGVKVLHGLEKVVE 261

  Fly   455 GRTVILTLKDQDVLNE----EEGDTLVNVNMVDEERYKK--NVANKKQNPLSYGYNVYEEQYDEL 513
            |..||||||||.||.:    .|.|.|.||.:.:::|..:  ..|.||:       .:|::::::
plant   262 GGAVILTLKDQSVLTDGDVNNEIDMLENVEIGEQKRRNEAYEAAKKKK-------GIYDDKFND- 318

  Fly   514 GNP-IERSVLEKYDDEM--EGQPKKRKNFVIGENMDEEREHRRKLLEIKTKLAGKRLETLEDTN- 574
             :| .|:.:|.:||:..  ||.....|....|       |..:||.|::.::.|:...|.||.|
plant   319 -DPGAEKKMLPQYDEAATDEGIFLDAKGRFTG-------EAEKKLEELRKRIQGQTTHTFEDLNS 375

  Fly   575 -LQLASDTYSAEELAKFKKPKKKVKKLRQKLKAEDLAPL---AMGEASGSSDFGSRGGRYRDHED 635
             .:::||.:|.||:.|||||||| |:||:|.|. ||:.|   |:....|:.|.|||    :|...
plant   376 SAKVSSDYFSQEEMLKFKKPKKK-KQLRKKDKL-DLSMLEAEAVASGLGAEDLGSR----KDGRR 434

  Fly   636 AEMEEFKPQIKVEVEDDDLERVLAK---ARKLKQKENIIKKPLPVD--------------FESIQ 683
            ..|:|.|.:|:.|...:..:..:||   |.:|.::|.:  :|...|              ::|::
plant   435 QAMKEEKERIEYEKRSNAYQEAIAKADEASRLLRREQV--QPFKRDEDESMVLADDAEDLYKSLE 497

  Fly   684 RE-----IKPEHVED--------TASGVVLTGVDGNIVLNATAE---FCRTLGDIPTYGMAGN-- 730
            :.     ||.|....        .||....|..|.....:.|.|   ....:||. .:|:...
plant   498 KARRLALIKKEEAGSGPQAVAHLVASSTNQTTDDNTTTGDETQENTVVFTEMGDF-VWGLQREND 561

  Fly   731 -RNEDSNDM-MDFD-KTEQPEEHMETHTDEPALSHGTWNSVNPDEVMQPADLD-NLGEDLEDRAI 791
             |..:|.|: |:.| ..:.|.|..|.|               ||.:.:..|.| :..||..|...
plant   562 VRKPESEDVFMEEDVAPKAPVEVKEEH---------------PDGLTEVNDTDMDAAEDSSDTKE 611

  Fly   792 L--DE---EPDVGAGVANALRLALSKGYLEKEEKNRPSNTKMAHLQAKNYSIEDKAAGEDEKVGR 851
            :  ||   |..||.|::.||:|...:|.|  :||.......|...::|...|.|...|::.|
plant   612 ITPDENIHEVAVGKGLSGALKLLKDRGTL--KEKVEWGGRNMDKKKSKLVGIVDDDGGKESK--- 671

  Fly   852 RDRFHFGPITDFKDKETFKPNVKLDYIDDNGRILNLKEAFRYLSHKFHGKGPGKNKIEKRLKKME 916
                      |.:.|:.|| :::::..|:.||.|..|||||.||||||||||||.|.|||:|:.:
plant   672 ----------DKESKDRFK-DIRIERTDEFGRTLTPKEAFRLLSHKFHGKGPGKMKEEKRMKQYQ 725

  Fly   917 QDGLMKTMSSTDTPLGTLTMLQQKQKETKTAYVVLSGN----------------NKNVPG 960
            ::..:|.|.::|||..::..:::.|.:.||.|:||||:                .|:|||
plant   726 EELKLKQMKNSDTPSQSVQRMREAQAQLKTPYLVLSGHVKPGQTSDPQSGFATVEKDVPG 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6686	NP_723700.1	SART-1	279..918	CDD:281354	185/698 (27%)
DOT2	NP_001318573.1	SF-CC1	38..>148	CDD:273721	45/145 (31%)
DOT2	NP_001318573.1	SART-1	171..727	CDD:397428	181/638 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	160	1.000	Domainoid score	I1272
eggNOG	1	0.900	-	-		E1_KOG2217
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55038
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003739
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103596
Panther	1	1.100	-	-	LDO	PTHR14152
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4756
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.870