DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6686 and snu-66

DIOPT Version :9

Sequence 1:	NP_723700.1	Gene:	CG6686 / 34608	FlyBaseID:	FBgn0032388	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_504952.1	Gene:	snu-66 / 179140	WormBaseID:	WBGene00017605	Length:	829	Species:	Caenorhabditis elegans

Alignment Length:	855	Identity:	264/855 - (30%)
Similarity:	421/855 - (49%)	Gaps:	191/855 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 RNRERSRSQSPASSSRKPATKEREPSSRSFSPIPENG-AGDVLSITETNKLRAKLGLKPLEVDSG 301
            :||:.|||.||..|.|  :.|:|||.        :|| ..|.:||.|||||||.|||.|||.:..
Worm    21 KNRDSSRSPSPPRSKR--SAKQREPE--------DNGEPADSMSIEETNKLRASLGLAPLETNDN 75

  Fly   302 PSKAGPPPGSSSQGEIKKPHGEADLSSYKDEWGEFLHKPADNLKEKREAEKLREKLKQRKEKRFL 366
            ..:      .::.|..:|        .|.::..||.|:.|:|:.:|::.:.::|||:..|.||.:
Worm    76 KER------DANDGTNEK--------IYNEDGFEFRHRKAENISDKKKEKDIKEKLEIAKAKRDV 126

  Fly   367 EERLARIKTLGESDEETDNVSKWVDKNKRVVNEREEAMRKAKELEELDEAFGVSEILEQEKTKAR 431
            ..::.:.|.|.:|||| |:.:.:|:|.::..:|.::|..:|...::|||..|||.|:::.|...:
Worm   127 YSKVLKAKKLADSDEE-DSAASFVNKMRQKEDEAKKAADRAAAFDQLDEELGVSAIVDKVKKPKK 190

  Fly   432 QRAYGDSNLKGLRVDHDMDDFGEGRTVILTLKDQDVLNEEEGD-TLVNVNMVDEERYKKNV-ANK 494
            .:..|.|:..|:.:.|..:.|.|| ..||.|:|:.||  ::|| .|||.|::|.||:.:|| ..|
Worm   191 PKTKGPSDTAGMVIGHGREAFIEG-DQILVLQDKGVL--DDGDEVLVNPNLLDNERHVRNVELRK 252

  Fly   495 KQNPLSYGYNVYEEQYDELGNPIERSVLEKYDDEMEGQPKKRKNFVIGENMDEEREHRRKLLEI- 558
            :::|    ...::|..||.||.....||.|||:.:||:.||:  |.:.|:...:.|..|:.:|.
Worm   253 RKDP----NRNFDEDVDEFGNAKNFGVLAKYDETLEGEQKKQ--FRLDEHGGVDLEEERREMEAF 311

  Fly   559 -KTKLAGKRLETLEDTNLQLASDTYSAEELAKFKKPK--KKVKKLRQK--LKAEDLAPLAMGEAS 618
             :.|:||||||:||....:|||:.|:.:|:.:|:|.|  ||.|.:|::  |||.||.|:.  :|.
Worm   312 RRMKMAGKRLESLETKKYELASEFYTQDEMTQFRKVKKGKKEKNIRKRKVLKASDLVPVE--KAG 374

  Fly   619 GSSDFGSR-----------------GGRYRDHE--DAEMEE------------------------ 640
            ...|||.|                 .|:..|.|  |.|:.|
Worm   375 EGRDFGRRRRDSDEPEDEGLKKEKQDGKDEDGEISDKEVPESSSDNGKWKKAMRGNGVDLQRLQK 439

  Fly   641 --FKPQIKVEVEDDD-------------------------LERVLAKARKLKQKENIIKKPLPVD 678
              .|.||   .||||                         |..:|||.||:||          :|
Worm   440 LRSKHQI---AEDDDSDNDLMFSGGVDLTGVVIDDNAEEELSSILAKTRKVKQ----------ID 491

  Fly   679 FESIQREIKPEHVED--TASGVVLTGVD----------GNIVLNATAEFCRTLGDIPTYGMAGNR 731
            .:.:..:: .:.|:|  |:.||.:. :|          |.|.:::|.|:||.:|:|.|.|:.|||
Worm   492 GKQMDNDV-GKKVQDILTSHGVKME-IDEEEDVKPLKEGQIYIDSTTEYCRHVGEITTLGLGGNR 554

  Fly   732 NEDSNDMMDFDKTEQPEEHME----------------------------THTDEPALSHGTWNSV 768
            ..|.:::....:.|..:|..|                            ....|||.|:...:|.
Worm   555 TVDVSEVKKVKEEEMEQEGSEGFEKWKRAKVDKELKEKEKRKLRDQGGWLAAGEPAPSNARIDSD 619

  Fly   769 NPDEVMQ---------PADLDNLGEDLEDRA-ILDEEPDVGAGVANALRLALSKGYLEKEEKNRP 823
            :.|.:.:         ..:.:::.||.:|.| .|.:|.||..||...|:||..||||:.......
Worm   620 DEDALEEAKKRKWSEDEEEDEDMEEDKDDYAPALGQEVDVSKGVGRMLKLAGQKGYLQNPNAKSH 684

  Fly   824 SNTKMAHLQAK--------NYSIEDKAAGEDEKVGRRDRFHFGPITDFKDKETFKPNVKLDYIDD 880
            |...:.||:.|        .:..:|:.|   :|..|.:..|.||:..|.:|..:||:|.:.|:|.
Worm   685 SGPSLDHLKNKTTQRIDGQRFDPDDRNA---KKADRLNSQHRGPVMPFAEKHDYKPDVNISYVDR 746

  Fly   881 NGRILNLKEAFRYLSHKFHGKGPGKNKIEKRLKKMEQDGLMKTMSSTDTPLGTLTMLQQKQKETK 945
            .||.::.|:|:|.||:||||:.|||.::|||..:.:::..|...:|.|||||||...::|||:..
Worm   747 KGREMDAKDAYRELSYKFHGRNPGKKQLEKRANRKDKEERMLKTNSYDTPLGTLDKQRKKQKQLS 811

  Fly   946 TAYVVLSGNN 955
            |.|:||||::
Worm   812 TPYLVLSGSS 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6686	NP_723700.1	SART-1	279..918	CDD:281354	230/774 (30%)
snu-66	NP_504952.1	SART-1	52..784	CDD:281354	230/775 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165948
Domainoid	1	1.000	268	1.000	Domainoid score	I983
eggNOG	1	0.900	-	-		E1_KOG2217
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H137789
Inparanoid	1	1.050	317	1.000	Inparanoid score	I1515
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55038
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003739
OrthoInspector	1	1.000	-	-		oto20116
orthoMCL	1	0.900	-	-		OOG6_103596
Panther	1	1.100	-	-	LDO	PTHR14152
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1368
SonicParanoid	1	1.000	-	-		X4756
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790