Protein Alignment EYS and Agrn

DIOPT Version :10

• Sequence 1: NP_001278938.1
• Gene: EYS / 346007
• HGNCID: 21555
• Length: 3165
• Species: Homo sapiens
• Sequence 2: XP_017448655.1
• Gene: Agrn / 25592
• RGDID: 2067
• Length: 2066
• Species: Rattus norvegicus
• Alignment Length: 3124
• Identity: 580/3124 - (18%)
• Similarity: 893/3124 - (28%)
• Gaps: 1336/3124 - (42%)

Human     9 LSLMVFHSSFINGK--TCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFLGVNT------- 64
            |.|:|..:..:.|.  ||..:.:|. ..:.::.|:..|:.|.:.:|..:..:...|..
  Rat    16 LLLLVVAARTLPGASGTCPERALER-REEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGK 79

Human    65 ------KIDTSGNQAV------PQICPLQIQLGD--ILVISSEPSLQFP-------------EIN 102
                  .:...||:.|      |.||..|:..||  |..::..|...:|             .|.
  Rat    80 DVVAQESLLDGGNKVVIGGFGDPLICDNQVSTGDTRIFFVNPAPPYMWPAHKNELMLNSSLMRIT 144

Human   103 LMNVSETSFVGCVQNTTTEDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNV 167
            |.|:.|..|  ||::                        ..|.|:         :|.|
  Rat   145 LRNLEEVEF--CVED------------------------KPGIHF---------TPAP------- 167

Human   168 TVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKR 232
                                              ..||         |.|....|
  Rat   168 ----------------------------------PTPP---------DVCRGMLC---------- 179

Human   233 ENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKP 297
                  .:..|                |:|.|...|..|        |.|.:.    .|..:..|
  Rat   180 ------GFGAV----------------CEPSVEDPGRAS--------CVCKKN----ACPATVAP 210

Human   298 CVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI- 361
                      :|.:.:|.|:.||....:..|.:..:......||.:...|..::......|.|.
  Rat   211 ----------VCGSDASTYSNECELQRAQCNQQRRIRLLRQGPCGSRDPCANVTCSFGSTCVPSA 265

Human   362 ---FTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEE 423
               ....||   .|:|...|  :...|.....|||                ..|:|||..|.::|
  Rat   266 DGQTASCLC---PTTCFGAP--DGTVCGSDGVDYP----------------SECQLLSHACASQE 309

Human   424 WCFNIIGRFKYVCIPGC----------------TKNPCWFLKNVYLIHQHLCYC---GVTFHGIC 469
               :|..:|...|.| |                |::|...|:......||...|   |||:...|
  Rat   310 ---HIFKKFNGPCDP-CQGSMSDLNHICRVNPRTRHPEMLLRPENCPAQHTPICGDDGVTYENDC 370

Human   470 QDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWF----PHEG 530
                     .:.::|  .:.|...|.|..........|.|...:       ||.|..    ||
  Rat   371 ---------VMSRIG--ATRGLLLQKVRSGQCQTRDQCPETCQF-------NSVCLSRRGRPH-- 415

Human   531 TKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHE----------------- 578
                    |||........||.:|  ...|:.| .|....|:.||:.:
  Rat   416 --------CSCDRVTCDGSYRPVC--AQDGHTY-NNDCWRQQAECRQQRAIPPKHQGPCDQTPSP 469

Human   579 ---------AVCKDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLC-------------- 620
                     |||..:..:..|.|.     |:|....|...|:..::...:|
  Rat   470 CHGVQCAFGAVCTVKNGKAECECQ-----RVCSGIYDPVCGSDGVTYGSVCELESMACTLGREIQ 529

Human   621 LALSHNCNCSGLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVP------GFKG---- 675
            :|....|:..|..|: .::||::|..|...|                :||.      |..|
  Rat   530 VARRGPCDPCGQCRF-GSLCEVETGRCVCPS----------------ECVESAQPVCGSDGHTYA 577

Human   676 TQCEIDIDEC----------ASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRC 730
            ::||:.:..|          |.| |:   ||    |...|.          |..:|:.|
  Rat   578 SECELHVHACTHQISLYVASAGH-CQ---TC----GEKVCT----------FGAVCSAG------ 618

Human   731 EQDIDDCILNACEH---NSTCKDLHLSYQCVCLSDWEGNFCEQ--ESNECKMNPCKNNSTCTDLY 790
                 .|:...|||   ...|....::|...|  :.....|:|  :..|....||:
  Rat   619 -----QCVCPRCEHPPPGPVCGSDGVTYLSAC--ELREAACQQQVQIEEAHAGPCE--------- 667

Human   791 KSYRCECTSGWTGQNCSEEINECDSDPC-MNGGLCHESTIPGQFVC--LCPPLYTGQFCHQ---R 849
               ..||.||.:|   |.|.:||:.:.| ..||:..|.:..|..||  .|..:.....|..   .
  Rat   668 ---PAECGSGGSG---SGEDDECEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPRSPVCGSDGVT 726

Human   850 YNL-CDL--------------LHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSC 899
            |.. |||              ....||..:....|..|..||                     :.
  Rat   727 YGTECDLKKARCESQQELYVAAQGACRGPTLAPLLPVAFPHC---------------------AQ 770

Human   900 QDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPF-- 962
            ..||.|:|   ||......|.:|         |.|.                |:|.|  ||.:
  Rat   771 TPYGCCQD---NFTAAQGVGLAG---------CPST----------------CHCNP--HGSYSG 805

Human   963 -CELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHD--GVCIDGIN 1024
             |:....:|.                    |.||..|:.|    |.|  ||...:  |:..||
  Rat   806 TCDPATGQCS--------------------CRPGVGGLRC----DRC--EPGFWNFRGIVTDG-- 842

Human  1025 HYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCM 1089
                                        |..||      |||||
  Rat   843 ----------------------------HSGCT------PCSCD--------------------- 852

Human  1090 NEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFS 1154
                            |||.....||:.                          |..|.|.||.:
  Rat   853 ----------------PRGAVRDDCEQM--------------------------TGLCSCRPGVA 875

Human  1155 GQFCEININECSSSPCLHGADCE-DHINGYVCKCQPGWSGHHCENELECIPNSCVHELCMENEPG 1218
            |..|    .:|.....|....|| |.:....|      ...|||....|:          |....
  Rat   876 GPKC----GQCPDGQVLGHLGCEADPMTPVTC------VEIHCEFGASCV----------EKAGF 920

Human  1219 STCLCTPGFMTC----------SIGLLCGDE--IRRITCLTPIFQRTDPISTQTYTIPPSETLVS 1271
            :.|:|..  :||          |.|:..|:|  ::.|.|.    ||.| ||||:.
  Rat   921 AQCICPT--LTCPEANSTKVCGSDGVTYGNECQLKAIACR----QRLD-ISTQSL---------- 968

Human  1272 SFPSIKATRIPAIMDTYPVDQGPKQTGIVKHDILPTTGLATLRISTPLESYLLQELIVTRELSAK 1336
                                 ||.|     ..:.|.....:..::||..       |:::.|...
  Rat   969 ---------------------GPCQ-----ESVTPGASPTSASMTTPRH-------ILSKTLPFP 1000

Human  1337 HSLLSSADVSSSRFLNFGIRDPAQIVQDKTSVSHMPIRTSAATLGFFFPDRRARTPFIMSSLMSD 1401
            |:.|..:              |.....|                   :|.....:|....|:...
  Rat  1001 HNSLPLS--------------PGSTTHD-------------------WPTPLPISPHTTVSIPRS 1032

Human  1402 FIFPTQSLLFENCQTVALSATPTTSVIRSIPGADIELNRQSLLSRGFLLIAASISATPVVSRGAQ 1466
            ..:|            .|:..||.:      .:|:            ..:|.||.:....:.|:.
  Rat  1033 TAWP------------VLTVPPTAA------ASDV------------TSLATSIFSESGSANGSG 1067

Human  1467 EDIEEYSADSLISRREHWRLLSPSMSPIFPAKVIISKQVTILNSSALHRFSTKAFNPSEYQAITE 1531
            :  ||.|.|...|......|..|..|            :.:.:...:.|.|.       |.:...
  Rat  1068 D--EELSGDEEASGGGSGGLEPPVGS------------IVVTHGPPIERASC-------YNSPLG 1111

Human  1532 ASSNQRLTNIKSQAADSLRELSQTCATCSMTEIKSSREFSDQVLHSKQSHFYETFWMNSAILASW 1596
            ..|:.:..::.|:.::           |..|:
  Rat  1112 CCSDGKTPSLDSEGSN-----------CPATK--------------------------------- 1132

Human  1597 YALMGAQTITSGHSFSSATEITPSVAFTEVPSLF--PSKKSAKRTILSSSLEESITLSSNLDVNL 1659
                         :|....|:..    .|...||  |.....|..:..   |.:.::.|.||
  Rat  1133 -------------AFQGVLELEG----VEGQELFYTPEMADPKSELFG---ETARSIESTLD--- 1174

Human  1660 CLDKTCLSIVPSQTISSDLM-NSDLTSKMTTDELSVSENILKLLKIRQYGITMGPTEVLNQESLL 1723
                             ||. |||:..    |..||        ::|:    :||.:::.
  Rat  1175 -----------------DLFRNSDVKK----DFWSV--------RLRE----LGPGKLVR----- 1201

Human  1724 DMEKSKGSHTLFKLHPSDSSLDFELNLQIYPDVTLKTYSEITHANDFKNNLPPLTGSVPDFSEVT 1788
                                                                             
  Rat  1202 ----------------------------------------------------------------- 1201

Human  1789 TNVAFYTVSATPALSIQTSSSMSVIRPDWPYFTDYMTSLKKEVKTSSEWSKWELQPSVQYQEFPT 1853
               |...|...|..:.|.|              |...:|.::::.|..|:....:|..::..|
  Rat  1202 ---AIVDVHFDPTTAFQAS--------------DVGQALLRQIQVSRPWALAVRRPLQEHVRF-- 1247

Human  1854 ASRHLPFTRSLTLSSLESILAPQRLMISDFSCVRYYGDSYLEFQNVALNPQNNISLEFQTFSSYG 1918
                                                                   |:|..|.:
  Rat  1248 -------------------------------------------------------LDFDWFPT-- 1255

Human  1919 LLLYVKQDSNLVDGFFIQLFIENGTLKYHFYCPGEAKFKSINTTVRVDNGQKYTLLIRQELDPCN 1983
                          ||                .|.|    ..||..:                ..
  Rat  1256 --------------FF----------------TGAA----TGTTAAM----------------AT 1270

Human  1984 AELTILGRNTQICESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVPVKNFTGCIEVIEINNWRS 2048
            |..|.:.|               ||.|
  Rat  1271 ARATTVSR---------------LPAS-------------------------------------- 1282

Human  2049 FIPSKAVKNYHINNCRSQGFMLSPTASFVDASDVTQGVDTMWTSV----SPSVAAPS-VCQQDVC 2108
               |...:.|..:..|..|...:|        ..|:...|..|::    :|....|| .|....|
  Rat  1283 ---SVTPRVYPSHTSRPVGRTTAP--------PTTRRPPTTATNMDRPRTPGHQQPSKSCDSQPC 1336

Human  2109 HNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPSFNGNSYLELPFLKFVLEKEHNRTV 2173
            .:||||.......|   |.|.|.....|..|||......|:|.|:|:|..|.|:..      .|:
  Rat  1337 LHGGTCQDQDSGKG---FTCSCTAGRGGSVCEKVQPPSMPAFKGHSFLAFPTLRAY------HTL 1392

Human  2174 TIYLTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTP 2238
            .:.|..:.....|.:|| |||..||.||.|.|::||...::..|:...:||          :..|
  Rat  1393 RLALEFRALETEGLLLY-NGNARGKDFLALALLDGRVQFRFDTGSGPAVLT----------SLVP 1446

Human  2239 ITIRYTTPVGSPGVVCMIE---------MTADGKPPVQKK----------DTEISHASQAYFESM 2284
            :         .||....:|         ::.||:.||..:          ||           ::
  Rat  1447 V---------EPGRWHRLELSRHWRQGTLSVDGETPVVGESPSGTDGLNLDT-----------NL 1491

Human  2285 FLGHIPAN--VQIHKKAGPVYGFRGCILDLQVNNKEFFIIDEARHGKNIENCHVPWCAHHLCRNN 2347
            ::|.||..  ..:..:.....|.:|||..|.:||::..:.|..|..  :::..|..|..|.|..|
  Rat  1492 YVGGIPEEQVAMVLDRTSVGVGLKGCIRMLDINNQQLELSDWQRAA--VQSSGVGECGDHPCLPN 1554

Human  2348 -----GTCISDNENLF-CECPRLYSGKLC--QFASCENNPCGNGATCVPKSGTDIVCLCPYGRSG 2404
                 ..|.:....:| |:||....|..|  :.:.|:.|||...|.|...|.....|.||.||||
  Rat  1555 PCHGGALCQALEAGMFLCQCPPGRFGPTCADEKSPCQPNPCHGAAPCRVLSSGGAKCECPLGRSG 1619

Human  2405 PLCTDAINI--TQPRFSGTDAFGYTSFLAYSRIS-DISFHYEFHLKFQLANNHSALQNNLIFFTG 2466
            ..|...:..  ::|..:..:.|.|.......... |:.......:.| ||...|    .|:.:.|
  Rat  1620 TFCQTVLETAGSRPFLADFNGFSYLELKGLHTFERDLGEKMALEMVF-LARGPS----GLLLYNG 1679

Human  2467 QKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRS-EPLNLSLGVHTVHLGKFFQEGWLKVDD- 2529
            ||..|..  ||:::.|.|..:.:.|:||.|.|.||| ||:.|...|. |.|.:..::|.|:|.|
  Rat  1680 QKTDGKG--DFVSLALHNRHLEFCYDLGKGAAVIRSKEPIALGTWVR-VFLERNGRKGALQVGDG 1741

Human  2530 -----HKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGH 2589
                 ...||...|..:  ||:....|:||..:::.  |..||...:||.|.|..:.:|    ||
  Rat  1742 PRVLGESPKSRKVPHTM--LNLKEPLYIGGAPDFSK--LARGAAVSSGFNGVIQLVSLR----GH 1798

Human  2590 --------FRGLGNPEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCT 2646
                    .|.:   :..|.|.....|...:||.     |||:|:
  Rat  1799 QLLTQEHVLRAV---DVSPFADHPCTQALGNPCL-----NGGSCV-------------------- 1835

Human  2647 ETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALI------------------ 2693
                            .|.||       |.|.||.|.:|::||:.|:
  Rat  1836 ----------------PREAT-------YECLCPGGFSGLHCEKGLVEKSVGDLETLAFDGRTYI 1877

Human  2694 --LIVILEKPK----PAERKVKKEALSISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADG 2752
              |..::|...    ||...:...|| .|:.:.:||                |.:|..:..|..|
  Rat  1878 EYLNAVIESELTNEIPAPETLDSRAL-FSEKALQSN----------------HFELSLRTEATQG 1925

Human  2753 ILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIILETLQKVTINGSTWHIIKAGRVGAEGY 2817
            ::.:..:  .|:..|::.:::|:..:||.|:||.:.::|.:..||  |.:.|..|:|.|...||.
  Rat  1926 LVLWIGK--AAERADYMALAIVDGHLQLSYDLGSQPVVLRSTVKV--NTNRWLRIRAHREHREGS 1986

Human  2818 LDL-DGINVTEKASTKMSSLDTNTDFYIGGVSSLNL--VNPMAIENEPVGFQGCIRQVIINNQEL 2879
            |.: :...||..:....:.|||:...::||:..|.:  ..|.|.   ..||.||:|.|::.:::|
  Rat  1987 LQVGNEAPVTGSSPLGATQLDTDGALWLGGLQKLPVGQALPKAY---GTGFVGCLRDVVVGHRQL 2048

Human  2880 QLTE 2883
            .|.|
  Rat  2049 HLLE 2052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EYS	NP_001278938.1	EGF_CA	215..253	CDD:238011	4/37 (11%)
		EGF_CA	681..731	CDD:238011	11/59 (19%)
		EGF_CA	733..769	CDD:214542	7/38 (18%)
		EGF_CA	773..806	CDD:238011	8/32 (25%)
		EGF_CA	810..846	CDD:238011	10/38 (26%)
		EGF_CA	890..926	CDD:238011	8/35 (23%)
		EGF_CA	929..964	CDD:238011	7/37 (19%)
		EGF_CA	966..1002	CDD:238011	5/35 (14%)
		EGF_CA	1004..1040	CDD:238011	7/37 (19%)
		EGF_CA	1080..1115	CDD:238011	3/34 (9%)
		EGF_CA	1118..1159	CDD:238011	6/40 (15%)
		EGF_CA	1161..1197	CDD:238011	7/36 (19%)
		LamG	1886..2044	CDD:238058	15/157 (10%)
		LamG	2149..2315	CDD:238058	43/186 (23%)
		LamG	2459..2582	CDD:214598	42/129 (33%)
		EGF	2614..2644	CDD:394967	5/29 (17%)
		EGF_CA	2657..2689	CDD:238011	9/31 (29%)
		LamG	2740..2877	CDD:214598	39/139 (28%)
		LamG	2977..3138	CDD:238058
Agrn	XP_017448655.1	NtA	33..148	CDD:460825	21/115 (18%)
		KAZAL	198..244	CDD:197624	9/59 (15%)
		KAZAL	274..319	CDD:197624	16/68 (24%)
		Kazal_1	351..391	CDD:395004	11/50 (22%)
		KAZAL_FS	423..463	CDD:238052	9/42 (21%)
		KAZAL	491..536	CDD:197624	7/49 (14%)
		KAZAL	556..601	CDD:197624	10/61 (16%)
		KAZAL	621..666	CDD:197624	9/46 (20%)
		KAZAL	706..752	CDD:197624	8/45 (18%)
		Laminin_EGF	795..837	CDD:395007	16/69 (23%)
		Laminin_EGF	849..>885	CDD:395007	17/102 (17%)
		KAZAL	924..971	CDD:197624	17/84 (20%)
		SEA	1130..1254	CDD:214554	36/356 (10%)
		Laminin_G_1	1398..1529	CDD:395008	37/161 (23%)
		Laminin_G_1	1666..1801	CDD:395008	49/150 (33%)
		EGF_CA	1823..1855	CDD:238011	15/79 (19%)
		Laminin_G_1	1919..2049	CDD:395008	37/136 (27%)