Protein Alignment EYS and Y46G5A.29

DIOPT Version :10

• Sequence 1: NP_001278938.1
• Gene: EYS / 346007
• HGNCID: 21555
• Length: 3165
• Species: Homo sapiens
• Sequence 2: NP_496734.4
• Gene: Y46G5A.29 / 174922
• WormBaseID: WBGene00012917
• Length: 756
• Species: Caenorhabditis elegans
• Alignment Length: 392
• Identity: 99/392 - (25%)
• Similarity: 148/392 - (37%)
• Gaps: 123/392 - (31%)

Human   658 STHLRGYFFRKCVPGFKGTQCEIDI-------------------------DECASHPCKNGATCI 697
            ||.:.|..|:|..|.......|.|:                         ::|..:||:||..|.
 Worm   318 STFMMGRMFKKFAPLNDTVLQEDDLKFLNSHVHHRMLQHDFVDNNDLEMEEKCQDNPCQNGGRCS 382

Human   698 DQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSD 762
            ...|...||              |||||||..| .:||.|:.|.|::|||           |.:|
 Worm   383 MSKGKSTCQ--------------CNPGYVGANC-TEIDKCLDNECDNNST-----------CFND 421

Human   763 WEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHES 827
                         |.:|.           .|.|:|.:|..|:.|  || ||..|.|.|||.|:.:
 Worm   422 -------------KRSPV-----------GYSCKCQNGTVGKLC--EI-ECPKDQCENGGQCYLN 459

Human   828 TIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVK 892
            |. |:..|.|.|..||:.|.:..|.|.  .|.|:|.:.|:.|.: :..|.|.:.:.|:|||...:
 Worm   460 TF-GKIGCKCVPGTTGRRCEREINECG--WNSCKNGAKCVDLFN-DYRCDCADGWMGRNCERPCQ 520

Human   893 DCLFLSCQDY---GDCEDMVN-----NFRCICRPG----------------------FSGSLCEI 927
            | ::.||:.:   |.|::|.|     :..|....|                      |:..|.|.
 Worm   521 D-IYGSCRVWKREGQCQEMRNATDFFDLNCAASCGVCVKVDNGTDESYLPLQPILMPFAFLLGEW 584

Human   928 EI------NECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTD 986
            |.      |..:..|...:|...:.|..|.......:..||    ||.......||:.:.:::.:
 Worm   585 ESTIKGWNNHTTDYPADMDGMIYNETITFSVAPSLSFGTPF----VNYTATMTSLDDPSNIHQYN 645

Human   987 GY 988
            |:
 Worm   646 GF 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EYS	NP_001278938.1	EGF_CA	215..253	CDD:238011
		EGF_CA	681..731	CDD:238011	17/74 (23%)
		EGF_CA	733..769	CDD:214542	10/35 (29%)
		EGF_CA	773..806	CDD:238011	7/32 (22%)
		EGF_CA	810..846	CDD:238011	16/35 (46%)
		EGF_CA	890..926	CDD:238011	11/65 (17%)
		EGF_CA	929..964	CDD:238011	7/40 (18%)
		EGF_CA	966..1002	CDD:238011	5/23 (22%)
		EGF_CA	1004..1040	CDD:238011
		EGF_CA	1080..1115	CDD:238011
		EGF_CA	1118..1159	CDD:238011
		EGF_CA	1161..1197	CDD:238011
		LamG	1886..2044	CDD:238058
		LamG	2149..2315	CDD:238058
		LamG	2459..2582	CDD:214598
		EGF	2614..2644	CDD:394967
		EGF_CA	2657..2689	CDD:238011
		LamG	2740..2877	CDD:214598
		LamG	2977..3138	CDD:238058
Y46G5A.29	NP_496734.4	Reeler	41..181	CDD:260081
		EGF_CA	371..402	CDD:238011	16/45 (36%)
		EGF_CA	404..442	CDD:238011	18/74 (24%)
		EGF_CA	444..478	CDD:238011	15/34 (44%)
		EGF_CA	481..516	CDD:238011	11/37 (30%)
		lipocalin_heme-bd-THAP4-like	574..749	CDD:381185	16/78 (21%)