DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EYS and jag2

DIOPT Version :9

Sequence 1:	NP_001278938.1	Gene:	EYS / 346007	HGNCID:	21555	Length:	3165	Species:	Homo sapiens
Sequence 2:	XP_012824896.2	Gene:	jag2 / 100497180	XenbaseID:	XB-GENE-485160	Length:	1224	Species:	Xenopus tropicalis

Alignment Length:	1343	Identity:	340/1343 - (25%)
Similarity:	512/1343 - (38%)	Gaps:	317/1343 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   374 CESFPLRNNATC---------KKCEKDY--------PCSCISGFTEKNCEKAIDHCKLLSINCLN 421
            |:......|..|         |.|.|::        ||:..||||      ::.....:.:|..|
Frog    52 CDDIKSAQNLDCGRDECDTYLKVCLKEFQAKITPTGPCNYGSGFT------SVLGGNTIYLNKYN 110

Human   422 EEWCFN--IIGRFKYVCIP---GCTKN-----PCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQ 476
            .:...|  ..||   :.||   ..|::     ..|...|...:.:.|....||:.|:...
Frog   111 HQGKSNPSESGR---ITIPFQFAWTRSFTLILEAWDWDNDTKVDEDLLIDRVTYAGVTSP----- 167

Human   477 FEYVWQL----GFAGSEGEKCQGVIDAYFFLAANCTEDATYVND-------PEDNNSSC---WFP 527
             |..|.|    |.......|.:...|..:: .:.|.:.....||       ..:...:|   |..
Frog   168 -EDQWTLLPLTGHVAQFDVKIRVKCDENYY-GSMCNKFCRPRNDFVGHYTCDSNGKKACMEGWMG 230

Human   528 HEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSC 592
            .|..:.||..||..|....:......|...|.| :|.....  ....|.|.: |::..:   |.|
Frog   231 AECKQAICKQGCDLLHGGCTVPGECKCHYGWQG-LYCSECV--PYPGCVHGS-CQEPWD---CKC 288

Human   593 SLSYIGRLCVVNVDYCLGNHSISVHGLCLAL---SHNCNCSGLQRYERNICEIDTEDCKSASCKN 654
            ..::.|.||..:::||..:|.....|.|:..   .:.|.|.  ..|....|||....|.|..|.|
Frog   289 ETNWGGLLCNKDLNYCGTHHPCLNGGTCMNTEPDKYYCACP--DGYSGQNCEIAEHACASNPCAN 351

Human   655 GTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSC 719
            ......:...|...|.||:.||.|.:|||||||:||.:|..|.|              :::||.|
Frog   352 DGVCHEVSSGFECHCPPGWTGTTCAVDIDECASNPCASGGECKD--------------LINGFEC 402

Human   720 LCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCE-QESNECKMNPCKNN 783
            :|.|.:.|..|:.|.::|....|.:...|::|...|.|.||..|.|..|. ::|::|. ..|:|.
Frog   403 ICPPQWAGTTCQLDANECEGKPCLNAYACRNLIGRYFCHCLPGWTGLNCHIKKSDDCH-GQCQNG 466

Human   784 STCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLC--HESTIPGQFVCLCPPLYTGQFC 846
            ..|.|....|||.|..|:.|:||..|:|:|.|.||.|||.|  |.:|    |.|.|.|.|:|..|
Frog   467 GICKDKVNGYRCICPRGFVGKNCEIELNKCASKPCQNGGTCEDHVNT----FRCHCAPGYSGTLC 527

Human   847 HQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKD-CLFLSCQDYGDCEDMVN 910
            ....:||:  .|||:|.:.|..| |.:.:|.|.::::|||| ..:|| |...||:....|...::
Frog   528 ELTVDLCE--PNPCQNKARCYNL-DGDYYCACSDDYDGKNC-THLKDHCKNSSCKIIDSCTIAIS 588

Human   911 ----------------------------NFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLT 947
                                        ||.|.|..||:|:.|...||:|...||||.|||.|
Frog   589 TNATQEGIRYISSNVCGPHGRCISQPGGNFTCSCDRGFTGAYCHENINDCLGTPCKNGGTCTD-- 651

Human   948 NRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEP 1012
                                                ..|.:.|.|..|:.|..|:||.::|...|
Frog   652 ------------------------------------EIDSFKCFCPNGWGGEFCDINYNDCSPNP 680

Human  1013 CLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLH-GRCTELINEYPCSCDADGTSTQC 1076
            |.:||.|||.:|.:.|:||:|:.|..|.:....|.:|.|.: |.|.:..:.:.|.|.:....:.|
Frog   681 CQNDGRCIDLVNDFACECKNGWKGKTCHSREYQCDANTCSNGGTCYDTGDSFHCLCCSGWEGSTC 745

Human  1077 KI-KINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDG 1140
            .: |.:.|...||.|.|.|..:...|:|:|..|:.|..|.::.::|     |...|.||||||||
Frog   746 NLAKNSSCLPNPCENGGTCVGNGDSFSCMCKEGWEGRTCTENTNDC-----NPYPCYNGGICVDG 805

Human  1141 PGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENEL----- 1200
            . :.|.|.|.|||:|..|.|||:||.||||.:||.|.|.||||.|.|..|.:|..|:..:
Frog   806 V-NWFRCECAPGFAGPDCRINIDECQSSPCAYGATCIDEINGYRCTCPSGRAGLRCQEVIGLGRS 869

Human  1201 ----------------ECIPNSCVHELCMENEPGSTCL---CTP---------GFMTCSIGLLCG 1237
                            ||  |||   .|::.  |..|.   |.|         ....|..|..|.
Frog   870 CWLKGMQYPHGGKWVEEC--NSC---YCLDG--GVECTKTWCGPKPCLLEHSKDKSRCPRGQDCE 927

Human  1238 DEIRRITCLTPIFQR----TDPISTQTYTIPPSETLVSSFPSIKATRIPAIMDTYPVDQGPKQTG 1298
            ..:....|..|..:.    :.|:......:|.|:.|.|:     ..||..|.::..|.||
Frog   928 ARVTPFKCFQPPCREWGECSAPLPAAVKCLPDSDYLDSN-----CARITLIFNSDKVPQG----- 982

Human  1299 IVKHDILPTTGLATLRISTPLESYL--LQELIVTRELSAKHSLLSSADVSSSRFLNFGIRDPAQI 1361
                              |.:|:..  ::.|...|.:|.:..|:...|||||  :...|......
Frog   983 ------------------TTVENVCSEIRYLPSLRTVSKERQLVVLCDVSSS--MEKAIEVAISF 1027

Human  1362 VQDKTSVSHMPIRTSAATLGFFFPDRRART-----------PFIMSSLMSDFIFPTQSLLFENCQ 1415
            :.......:..|:.:|.|:......|:..|           ..::.|..||::.|....:|
Frog  1028 ISQTDDKDNSLIQNAANTIVNAITKRQNSTVMLAVTEVKVETMVVGSSHSDYLIPVLCTVF---- 1088

Human  1416 TVALSATPTTSVIRSIPGADIELNRQSLLSRGFLLIAASISATPVVSRGAQEDIEEYSADSLISR 1480
                                           ..:.|...|.....:.:..:|.......:|..::
Frog  1089 -------------------------------SIVWITCIIICVWWMRKRRKERERRCQEESANNQ 1122

Human  1481 REHWRLLSPSMSPIFPAKVIISKQVTILNSSALHRFSTKAFNPSEYQAITEASSNQRLTNIKSQA 1545
            ||   ||:|..:||...          .|...:| :..|.| .|..:...:....::...:..:.
Frog  1123 RE---LLNPIWNPIGAP----------YNQKDIH-YECKNF-LSHQKRTYDTEEEEKEEEVGEEV 1172

Human  1546 ADSLRELSQTC---------ATCS-MTEIKSSREFSDQVLHSK 1578
            .:..:.|||||         ..|| .:.:|.....||..:.::
Frog  1173 TEVDKCLSQTCPKTLTSKGDVDCSESSPVKKPHRTSDYKMDNR 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EYS	NP_001278938.1	Plasmod_Pvs28	195..>283	CDD:283826
		EGF_CA	681..731	CDD:238011	18/49 (37%)
		EGF_CA	733..769	CDD:238011	11/35 (31%)
		EGF_CA	773..806	CDD:238011	11/32 (34%)
		EGF_CA	810..846	CDD:238011	17/37 (46%)
		EGF_CA	890..926	CDD:238011	13/64 (20%)
		EGF_CA	929..964	CDD:238011	11/34 (32%)
		EGF_CA	966..1002	CDD:238011	5/35 (14%)
		EGF_CA	1004..1040	CDD:238011	15/35 (43%)
		EGF_CA	1080..1115	CDD:238011	11/34 (32%)
		EGF_CA	1118..1159	CDD:238011	18/40 (45%)
		EGF_CA	1161..1197	CDD:238011	20/35 (57%)
		LamG	1886..2044	CDD:238058
		LamG	2149..2315	CDD:238058
		Laminin_G_2	2461..2582	CDD:280389
		EGF_CA	2657..2689	CDD:238011
		LamG	2740..2877	CDD:214598
		Laminin_G_2	3007..3138	CDD:280389
jag2	XP_012824896.2	MNNL	29..103	CDD:400141	12/56 (21%)
		DSL	171..233	CDD:396134	10/62 (16%)
		EGF_CA	300..338	CDD:238011	8/39 (21%)
		EGF	344..372	CDD:394967	8/27 (30%)
		EGF_CA	378..414	CDD:238011	18/49 (37%)
		EGF_CA	416..451	CDD:238011	11/34 (32%)
		EGF_CA	457..490	CDD:238011	12/33 (36%)
		EGF_CA	494..528	CDD:238011	17/37 (46%)
		EGF_CA	531..566	CDD:238011	15/38 (39%)
		EGF_CA	634..669	CDD:238011	16/72 (22%)
		EGF_CA	674..707	CDD:238011	14/32 (44%)
		EGF_CA	715..745	CDD:238011	6/29 (21%)
		EGF_CA	755..785	CDD:238011	10/29 (34%)
		EGF_CA	787..822	CDD:238011	18/40 (45%)
		EGF_CA	825..861	CDD:238011	20/35 (57%)
		VWC_out	870..940	CDD:214565	15/76 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910