Protein Alignment Mal-B2 and SLC3A2

DIOPT Version :10

• Sequence 1: NP_723693.3
• Gene: Mal-B2 / 34598
• FlyBaseID: FBgn0032382
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001012680.1
• Gene: SLC3A2 / 6520
• HGNCID: 11026
• Length: 631
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 119/566 - (21%)
• Similarity: 192/566 - (33%)
• Gaps: 176/566 - (31%)

  Fly    34 WWPHTVFYQIYPRSFKDSNGDGIGDLKGITSKLRYLADTGITATWLSPIFQSPMIDFGYDISDYK 98
            ||.....|:|  ...:...|.|.|:|.|:..:|.||:...:....|.||.::...|...  :|..
Human   219 WWHTGALYRI--GDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQ--TDLL 279

  Fly    99 AIQPEYGTMQDFEELIDTAFELGIKVVLDFVPNHSSDQHEWFKKSAAREPGYEDFYVWHDGIVQE 163
            .|.|.:|:.:||:.|:.:|.:..|:|:||..||:.. ::.||
Human   280 QIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRG-ENSWF----------------------- 320

  Fly   164 NGTRVPPNNWPSVFYGSAWEWHEGREQYYLHQFTKEQPDLNYRNPKVVQAMDDVLLFWLNKGVAG 228
             .|:|                                       ..|...:.|.|.|||..||.|
Human   321 -STQV---------------------------------------DTVATKVKDALEFWLQAGVDG 345

  Fly   229 FRIDAVNHLFEDESLKDE---PLSGKTTDSLSYDYTKHIYSRDLPEVLEMIHHWRQLLDDFSAKH 290
            |::..:.:|.:..|...|   ...|.:.|.|....|.   |.||.::|.::...:.||
Human   346 FQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTN---SSDLQQILSLLESNKDLL------- 400

  Fly   291 PERPTRIMMTEAYAGLTQLADYYEDSNGVRGSHLPFNFHFITDVKGDSDARDYVYNVEKWLIYMP 355
                    :|.:|     |:|     :|..|.|                        .|.|:...
Human   401 --------LTSSY-----LSD-----SGSTGEH------------------------TKSLVTQY 423

  Fly   356 RGHAAN-WVMGNHDNPRVASRFGPASVDAM-NMLLLTLPGVAVTYNGEELGMVDYRELSWEETVD 418
            .....| |...:....|:.:.|.||.:..: .::|.||||..|...|:|:|:            |
Human   424 LNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGL------------D 476

  Fly   419 PPARNVGEKLYQEVSRDPVRTPFQ-WNNETNAGFSTAAKTWLPVHPNYLELNL--EAQKVANRSH 480
            ..|          :...|:..|.. |:..:           .|..|..:..|:  :.|.....|.
Human   477 AAA----------LPGQPMEAPVMLWDESS-----------FPDIPGAVSANMTVKGQSEDPGSL 520

  Fly   481 YQVYKDLLELR-KSAIMRVGRFNIEPLTRWVFAFKRSYPNFESIITVINVSDKE-----QLVDLS 539
            ..:::.|.:.| |...:..|.|:.......:|::.|.:...|..:.|:|..|..     |..||.
Human   521 LSLFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLP 585

  Fly   540 EFLSQPKKLVVEVSGVDSKYQPGQS----LAASALLLAAREGLVCR 581
            ...|.|.|..:.:|     .|||:.    |....|.|...|||:.|
Human   586 ASASLPAKADLLLS-----TQPGREEGSPLELERLKLEPHEGLLLR 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mal-B2	NP_723693.3	AmyAc_maltase	33..502	CDD:200467	95/476 (20%)
SLC3A2	NP_001012680.1	SLC3A2_N	161..226	CDD:464983	2/6 (33%)
		AmyAc_SLC3A2	208..537	CDD:200483	94/470 (20%)
		DUF3459	520..625	CDD:432205	27/109 (25%)