DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-B2 and CD98hc

DIOPT Version :9

Sequence 1:	NP_001188791.2	Gene:	Mal-B2 / 34598	FlyBaseID:	FBgn0032382	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001262354.2	Gene:	CD98hc / 40941	FlyBaseID:	FBgn0037533	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	120/541 - (22%)
Similarity:	200/541 - (36%)	Gaps:	110/541 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IMAGLVKSDTEDFIDWW---PHTVFYQIYPRSFKDSNGDGIGDLKGITSKLRYLADTGITATWLS 80
            |:.|..|......:.|:   ||..|..:.....:|..         :..||       ::|   .
  Fly   166 IIIGAPKCAAPQPLPWYKRGPHAKFASVETCRPEDVQ---------VAKKL-------VSA---G 211

  Fly    81 PIFQSPMIDFGYDISDYKAIQPEYGTMQDFEELIDTAFEL----GIKVVLDFVPNHSSDQHEWFK 141
            .|::.|.. ..||:.     :||      .||.|.....|    ..:|:||..||::: ::....
  Fly   212 AIYELPAA-LTYDVK-----KPE------VEEKIKHLVALYQGSDTRVILDLTPNYAA-KNSQLV 263

  Fly   142 KSAAREPGYEDFYVWHDGIVQENGTRVPPNNWPSVFYGSAWEWHEGREQYYLHQFTKEQPDLNYR 206
            :.|...|.....:||      .:|.:..||||..| .|:...|.:..:.|.|.||.....||...
  Fly   264 QDAIANPEKRSAFVW------VSGGKALPNNWLKV-GGNRSAWEKVGDNYVLSQFEDGYYDLKMN 321

  Fly   207 NPKVVQAMDDVLLFWLNKGVAGFRIDAVNHLFEDESLKDEPLSGKTTD-SL---SYDYTKHIYSR 267
            :..:......||...:..||.|||:.........:||:||.:|....| ||   .|.:..|..:.
  Fly   322 STIIRNEFGAVLKHLVALGVRGFRLKNTKFFALFDSLEDEQISSSPKDFSLGPNEYGFYSHRQTT 386

  Fly   268 DLPEVLEMIHHWRQLLDD------FSAKHPERPTRIMMTEAYAGLTQLADYYEDSNGVRGSHLPF 326
            .|..:.::::.:..::.:      ||....     :|..:.|    ||:    ..:|..|..||.
  Fly   387 FLSGLGDVLYDYLSIVKNASDEAFFSVAED-----VMEPQVY----QLS----GDSGAYGIDLPM 438

  Fly   327 NFHFI---TDVKGDSDARDYVYNVEKWLIYMPRGHAANWVMGNHDNPRVASRFGPASVDAMNMLL 388
            ..:|:   :..|.|:..:..:.|.      :.:....:|:..|..:..|.:   |....|:.|.|
  Fly   439 YGNFVKVLSKSKPDTSLQKELDNT------LAQSGTDSWLQWNLADVYVDT---PQDPSALAMFL 494

  Fly   389 LTLPGV------AVTYNG--EELGMVDYREL-SWEETVDPPARNVGEKLYQEVSRDPVRTPFQWN 444
            ..||||      ||.|..  ||    .||:: |..:|......|:  .|||   .||: ..|...
  Fly   495 SLLPGVPVVAVDAVAYQNVTEE----TYRQITSLRKTASYMHGNL--NLYQ---ADPL-VAFSRI 549

  Fly   445 NETNAG-FSTAAKTWLPVHPNYLELNLEAQKVANRSHYQVYKDLLELRKSAIMRVGRFNIEPLTR 508
            ...|.| |.....|.||...|:...:....|:......:.|.:.:: ....:...||.|::.|
  Fly   550 KSGNPGYFVIFNPTELPQASNFTIPDNLPDKMTVSYFSEQYNNNMD-NSGKVAHAGRVNLKDL-- 611

  Fly   509 WVFAFKRSYPNFESIITVINV 529
                  :..|:...|:|.:.|
  Fly   612 ------KVAPHSSIILTYVPV 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-B2	NP_001188791.2	AmyAc_maltase	33..502	CDD:200467	111/498 (22%)
Mal-B2	NP_001188791.2	Malt_amylase_C	510..>541	CDD:351862	4/20 (20%)
CD98hc	NP_001262354.2	AmyAc_maltase-like	117..593	CDD:200468	112/497 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1384693at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.820