DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-B2 and Mal-A4

DIOPT Version :9

Sequence 1:	NP_001188791.2	Gene:	Mal-B2 / 34598	FlyBaseID:	FBgn0032382	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_610381.1	Gene:	Mal-A4 / 35827	FlyBaseID:	FBgn0033294	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	579	Identity:	278/579 - (48%)
Similarity:	373/579 - (64%)	Gaps:	18/579 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LFSLLNSGSIMAGLVKSDTEDFIDWWPHTVFYQIYPRSFKDSNGDGIGDLKGITSKLRYLADTGI 74
            ||.||.     .||:..|..  ..||....||||||||||||:|:|:|||.|:|.||.||.:.|:
  Fly     7 LFLLLG-----LGLLAVDAA--APWWKTASFYQIYPRSFKDSDGNGVGDLNGVTEKLEYLKEIGV 64

  Fly    75 TATWLSPIFQSPMIDFGYDISDYKAIQPEYGTMQDFEELIDTAFELGIKVVLDFVPNHSSDQHEW 139
            |||||||..:|||.||||||||:||:.|.:|||:|||.::..|.|||:|::||||||||||:.:|
  Fly    65 TATWLSPFLKSPMADFGYDISDFKAVDPLFGTMEDFENMVSRAKELGVKIILDFVPNHSSDECDW 129

  Fly   140 FKKSAAREPGYEDFYVWHDGIVQENGTRVPPNNWPSVFYGSAWEWHEGREQYYLHQFTKEQPDLN 204
            |.:|||.|..|:|:|:||.|.:.|:|||.||.||.|||.||||||||||::||||||.|:|||.|
  Fly   130 FLRSAAGEEEYKDYYMWHPGFLDEDGTRRPPTNWVSVFRGSAWEWHEGRQEYYLHQFHKKQPDFN 194

  Fly   205 YRNPKVVQAMDDVLLFWLNKGVAGFRIDAVNHLFEDE-----SLKDEPLSGKTTDSLSYDYTKHI 264
            :|||.|.:.|::||.|||.|||.|||:||:.|.||.|     :..|||.:..|.|...|.||..|
  Fly   195 FRNPVVREEMNNVLRFWLEKGVDGFRVDAIYHAFEIEADENGNYPDEPRNDWTNDPDEYGYTHKI 259

  Fly   265 YSRDLPEVLEMIHHWRQLLDDFSAKHPERPTRIMMTEAYAGLTQLADYYEDSNGVRGSHLPFNFH 329
            |:.|.||...:::.|||:|:.|.|.: ....||:|.|.::.:..:..||.:.. ..|:.:||||.
  Fly   260 YTVDQPETPHLVYEWRQILEQFQADN-GGDERILMVETWSPIEIVMHYYGNET-ADGAQIPFNFQ 322

  Fly   330 FITDVKGDSDARDYVYNVEKWLIYMPRGHAANWVMGNHDNPRVASRFGPASVDAMNMLLLTLPGV 394
            .|:::..||||..|.|.:..||..||.|.:||||:||||..||.||||...||..|:|||||||.
  Fly   323 LISNLHYDSDAYHYEYLINNWLNLMPEGKSANWVIGNHDKNRVGSRFGADRVDLFNILLLTLPGC 387

  Fly   395 AVTYNGEELGMVD-YRELSWEETVDPPARNVGEKLYQEVSRDPVRTPFQWNNETNAGFSTAAKTW 458
            ::||.||||||:| |  :|||:||||.|.|..|..|.:.||||.|||..|::||.|||:|...||
  Fly   388 SITYQGEELGMLDGY--VSWEDTVDPQACNGYEANYMDNSRDPARTPMHWSDETMAGFTTGNSTW 450

  Fly   459 LPVHPNYLELNLEAQKVANRSHYQVYKDLLELRKSAIMRVGRFNIEPLTRWVFAFKRSYPNFESI 523
            |||..:|.:.|::.::..:.||..|:|.|.:||:...:..|...::.::.:|.|.||........
  Fly   451 LPVSTDYRQRNVKTERGVSLSHLNVFKRLQQLRQEPSIEEGSAEVKAVSNYVLAVKRHLSGDFVY 515

  Fly   524 ITVINVSDKEQLVDLSE-FLSQPKKLVVEVSGVDSKYQPGQSLAASALLLAAREGLVCR 581
            |::.|:.|..:.|:||. |.|.|.|....:....|..:.|..::|.::.|...|.:|.|
  Fly   516 ISLFNIFDSIENVNLSSVFGSLPAKFQYALVTEKSIKKVGDQVSAGSVTLMPHESIVLR 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-B2	NP_001188791.2	AmyAc_maltase	33..502	CDD:200467	250/474 (53%)
Mal-B2	NP_001188791.2	Malt_amylase_C	510..>541	CDD:351862	10/31 (32%)
Mal-A4	NP_610381.1	AmyAc_maltase	24..492	CDD:200467	249/471 (53%)
Mal-A4	NP_610381.1	Alpha-amylase	47..401	CDD:278554	192/355 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469251
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	1	0.950	-	0.709012	Normalized mean entropy	S2995
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R680
SonicParanoid	1	1.000	-	-		X202
	12	11.880