DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-B2 and Mal-A2

DIOPT Version :9

Sequence 1:	NP_001188791.2	Gene:	Mal-B2 / 34598	FlyBaseID:	FBgn0032382	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_476625.2	Gene:	Mal-A2 / 35825	FlyBaseID:	FBgn0002569	Length:	567	Species:	Drosophila melanogaster

Alignment Length:	591	Identity:	259/591 - (43%)
Similarity:	361/591 - (61%)	Gaps:	49/591 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LIQILLFSLLNSGSIMAGLVKSDTEDFIDWWPHTVFYQIYPRSFKDSNGDGIGDLKGITSKLRYL 69
            |..:||.|....|          |.| ||||.:...||||||||:||:||||||||||||:|.||
  Fly     9 LAALLLISTTQEG----------TAD-IDWWENASLYQIYPRSFQDSDGDGIGDLKGITSRLGYL 62

  Fly    70 ADTGITATWLSPIFQSPMIDFGYDISDYKAIQPEYGTMQDFEELIDTAFELGIKVVLDFVPNHSS 134
            .:.|||||||||||.|||.|||||||::..|.|.:||::||::||..|..||:|::|||||||||
  Fly    63 KEIGITATWLSPIFTSPMSDFGYDISNFYDIDPIFGTLEDFDDLIVEAKSLGVKIILDFVPNHSS 127

  Fly   135 DQHEWFKKSAAREPGYEDFYVWHDG-IVQENGTRVPPNNWPSVFYGSAWEWHEGREQYYLHQFTK 198
            |::.||:||..||.||:|||||.|| :.:|.|.|.||:||.|||.|..|.|:|.|:||:||||..
  Fly   128 DENVWFEKSVNREDGYDDFYVWDDGKLNEETGARDPPSNWVSVFSGPMWTWNEKRQQYFLHQFQV 192

  Fly   199 EQPDLNYRNPKVVQAMDDVLLFWLNKGVAGFRIDAVNHLFE----DESLKDEPLSGKTTDSLSYD 259
            :|||||:.||.|.:.|.|||.|||::||.|||||||.|::|    |.|..|||:||..:|..:||
  Fly   193 KQPDLNFTNPMVREHMLDVLKFWLDRGVDGFRIDAVPHIYEHRNADGSYPDEPVSGWGSDPNAYD 257

  Fly   260 YTKHIYSRDLPEVLEMIHHWRQLLDDFSAKHPERPTRIMMTEAYAGLTQLADYYEDSNGVRGSHL 324
            |..|||::|.|..:::::.||:.||::.|:: ...:|:::.|||:.:..|:.|:.:|.. :|:.|
  Fly   258 YHDHIYTKDQPATVDLMYEWREFLDNYRAQN-GGDSRVLLAEAYSSVETLSAYFGNSTH-QGTQL 320

  Fly   325 PFNFHFITDVKGDSDARDYVYNVEKWLIYMPRGH-AANWVMGNHDNPRVASRFGPASVDAMNMLL 388
            |.||..:. :.|.|.|:|.|.:::.|:..|.:.| .||||:||||..|||.|.|...||.:|:::
  Fly   321 PMNFQLMY-LSGYSTAKDVVGSIDYWMNTMWKEHQTANWVVGNHDTNRVADRMGAHKVDLLNVIV 384

  Fly   389 LTLPGVAVTYNGEELGM--VDYRELSWEETVDPPARNVGEKLYQEVSRDPVRTPFQWNNETNAGF 451
            ..|||.:|||.|||:||  ||. |.:.:...|               ||..|||.||....||.|
  Fly   385 NALPGASVTYYGEEIGMSNVDV-ECTGDSCED---------------RDGERTPMQWTAGKNADF 433

  Fly   452 STAAKTWLPVHPNYLELNLEAQKVANRSHYQVYKDLLELRKS----AIMRVGRFNIEPLTRWVFA 512
            |....||||:.|.|...|::.::..:||...::|.|.||:.|    |....|.|:.|.:|..|..
  Fly   434 SDGESTWLPLSPEYQRYNVQTERGVSRSSLNIFKGLQELKSSSAFLAFKEDGGFSYEAVTEQVLQ 498

  Fly   513 FKRSYPNFESIITVINVSDKEQLVD-LSEFLSQPKKLVVEVSGVDSKYQPGQSLAAS-ALLLAAR 575
            ..|:....|....::|:.:..:::| |:     ||.....::...|.:..||....| .::|...
  Fly   499 IIRTNKISEEYRILVNMGNGMEILDGLA-----PKTYEYVLATAYSTHYSGQKADLSQRIILMPY 558

  Fly   576 EGLVCR 581
            |.:|.|
  Fly   559 EAVVLR 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-B2	NP_001188791.2	AmyAc_maltase	33..502	CDD:200467	232/480 (48%)
Mal-B2	NP_001188791.2	Malt_amylase_C	510..>541	CDD:351862	6/31 (19%)
Mal-A2	NP_476625.2	AmyAc_maltase	24..484	CDD:200467	233/479 (49%)
Mal-A2	NP_476625.2	Alpha-amylase	50..405	CDD:278554	184/357 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469253
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	10	9.900