DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-B1 and IMA2

DIOPT Version :9

Sequence 1:	NP_609522.1	Gene:	Mal-B1 / 34597	FlyBaseID:	FBgn0032381	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_014485.1	Gene:	IMA2 / 854008	SGDID:	S000005517	Length:	589	Species:	Saccharomyces cerevisiae

Alignment Length:	604	Identity:	201/604 - (33%)
Similarity:	300/604 - (49%)	Gaps:	91/604 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 WWQHEVFYQIYPRSFQDSNGDGIGDLQGITSRLQYFKDTGITSVWLSPIYESPMVDFGYDISNYT 97
            ||:....|||||.||:|||.||.||::||.|:|:|.|:.|..::|:||.|:||..|.||||:||.
Yeast    14 WWKEATIYQIYPASFKDSNNDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYE 78

  Fly    98 NIQPEYGTLEDFDALIAKANELGVKVILDFVPNHSSNKHPWFIKSVAREPG-YEDFYVWE--DGI 159
            .:.|.|||.||..|||.|.::||:|.|.|.|.||.|::|.||.:|.:.:.. ..|::.|.  .|.
Yeast    79 KVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGY 143

  Fly   160 LLENGTRVPPNNWLSVFSGSAWMWNDERQQYYLRQFTYGQPDLNYRNPAVIKAM-DDVMLFWLNK 223
            ..| |..:|||||.|.|.||||.::::.|::|||.|...|||||:.|....||: :..:.:||:.
Yeast   144 DAE-GKPIPPNNWRSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDH 207

  Fly   224 GIAGFRIDAIIYIYEDAQLRDEPPSGTTDDPNNEAYLSHIYTRNQPEDYGLLQHWRQLLDNYTAN 288
            |:.|||||......:.|.|.|.|    ..|.|::...|..:|.|.|.    :..:.|.::.:..|
Yeast   208 GVDGFRIDVGSLYSKVAGLPDAP----VIDENSKWQPSDPFTMNGPR----IHEFHQEMNKFIRN 264

  Fly   289 H--DGPLRIMMTEG------------YASVS--QLMEYYEDSNGVQGPQFPFNFDFIT-ELNANS 336
            .  ||  |.:||.|            |.|.|  :|.|.:..|:...|....|..:.|. ||....
Yeast   265 RVKDG--REIMTVGEMQHATDETKRLYTSASRHELSELFNFSHTDVGTSPKFRQNLIPYELKDWK 327

  Fly   337 TA-ADFVFYISR---W-LIYMPHGHVANWVMGNHDNPRVASRFGEKSV-------DAMNMLLMTL 389
            .| |:...|::.   | .||:.          |||.||..:|||:.|.       ..:::||::|
Yeast   328 VALAELFRYVNGTDCWSTIYLE----------NHDQPRSITRFGDDSPKNRVISGKLLSVLLVSL 382

  Fly   390 PGIGITYNGEELG--------MTDYRDISWSDTVDQPACEAGIDNYK----------TISRDPER 436
            .|....|.|:|||        :..|.|:...:..|....|.| :|.|          .||||..|
Yeast   383 SGTLYVYQGQELGEINFKNWPIEKYEDVEVRNNYDAIKEEHG-ENSKEMKRFLEAIALISRDHAR 446

  Fly   437 TPMQWS-SDVNAGFSSAD-RTWLPVNPNYKE-LNLRNQQQARRSHYKIYQSLLKLRQL--PVLKN 496
            |||||| .:.|||||..: :.|..:|.:::| :|..::.:...|....::..|:.|:.  .:...
Yeast   447 TPMQWSREEPNAGFSGPNAKPWFYLNESFREGINAEDESKDPNSVLNFWKEALRFRKAHKDITVY 511

  Fly   497 G---SFVPEVVNRRVFAFKRELKNEHTLLTIVNVSNRTELVDIADFIEQPNRLSVLVAGVDSQHR 558
            |   .|: ::.|:::|:|.::..|: ||...:|.|:     |..|| ..||..|.......:..|
Yeast   512 GYDFEFI-DLDNKKLFSFTKKYDNK-TLFAALNFSS-----DSIDF-TIPNNSSSFKLEFGNYPR 568

  Fly   559 VGDRLKAETIELAPNEGLV 577
              ..:.|.:..|.|.||.:
Yeast   569 --SEVDASSRTLKPWEGRI 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-B1	NP_609522.1	AmyAc_maltase	30..500	CDD:200467	180/525 (34%)
Mal-B1	NP_609522.1	trehalose_treC	33..538	CDD:274115	190/563 (34%)
IMA2	NP_014485.1	AmyAc_SI_OligoGlu_DGase	16..503	CDD:200472	176/508 (35%)
IMA2	NP_014485.1	Malt_amylase_C	514..585	CDD:406946	21/80 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342196
Domainoid	1	1.000	192	1.000	Domainoid score	I624
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	257	1.000	Inparanoid score	I641
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm9159
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	O	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
TreeFam	0	0.000	Not matched by this tool.
	11	10.790