DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-B1 and zgc:158423

DIOPT Version :9

Sequence 1:	NP_609522.1	Gene:	Mal-B1 / 34597	FlyBaseID:	FBgn0032381	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_001073552.1	Gene:	zgc:158423 / 790938	ZFINID:	ZDB-GENE-061215-58	Length:	480	Species:	Danio rerio

Alignment Length:	575	Identity:	107/575 - (18%)
Similarity:	190/575 - (33%)	Gaps:	182/575 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GLVGILAHKHQSKELDAKYNWWQHEVFYQIYPRSFQDSNGDGIGDLQGITSRLQYFKDTGITSVW 77
            |.:.|:....:.|.: .:.:||.....|||     .|.|......|:|:..:|.|.....:..|.
Zfish    73 GAIVIIVQAPRCKPI-PEMHWWNEGPLYQI-----SDVNAFTESGLKGLEGKLDYLSQMNVAGVV 131

  Fly    78 LSPIYESPMVDFGYDISNYTNIQPEYGTLEDFDALIAKANELGVKVILDFVPNHSSNKHPWFIKS 142
            |.||: |..:| ..|..|..::|.|.||..:.::|:..|::.|:.::|:..||.:..
Zfish   132 LGPIH-SLKID-QLDTLNLISVQSEVGTENELESLLGLAHKKGIFIVLNLTPNFNKT-------- 186

  Fly   143 VAREPGYEDFYVWEDGILLENGTRVPPNNWLSVFSGSAWMWNDERQQYYLRQFTYGQPDLNYRNP 207
                                                |||..|..
Zfish   187 ------------------------------------SAWFNNFN--------------------- 194

  Fly   208 AVIKAMDDVMLFWLNKGIAGFRIDAIIYIYEDAQLRDEPPSGTTDDPNNEAYLSHIYTRNQ-PED 271
            ||.:.:.|...:||:||:.|..:..:..|..||.     ||           :..|:.|:. .::
Zfish   195 AVAEKIKDACTYWLDKGLDGIFLSDLNEIPTDAW-----PS-----------IKEIFNRSDATKE 243

  Fly   272 YGLLQHWRQLLDN---YTANHDGPLRIMMTEGYASVSQLMEYYEDSNGVQGPQFPFNFDFITELN 333
            ..|:.....:..|   ...|..| :.:::| |...:|       ||...|.       ..|.|.|
Zfish   244 VALMGSVNSMSVNDISVLLNRSG-VDLLLT-GQPDLS-------DSGEKQA-------QIIKEFN 292

  Fly   334 ANSTAADFVFYISRWLIYMPHGHVANWVMGNHDNPRVASRFGEKSVDAMNMLLMTLPGIGITYNG 398
            ::......                 .| ....|...:|:.|   .:....:||.||||..:...|
Zfish   293 SSIQQTSL-----------------GW-RSRQDPGTLAAEF---PIRLYQILLFTLPGTPVFSAG 336

  Fly   399 EELGMTDYRDISWSDTVDQPACEAGIDNYKTISRDPERTPMQWSSDVNAGFSSADRTWLPVNP-- 461
            ||||:                            :..|:....|..:               ||
Zfish   337 EELGL----------------------------KAEEQLQALWDLE---------------NPVE 358

  Fly   462 --NYKELNLRNQQQARRSHYKIYQSLL-KLRQLPVLKNGSFVPEVVNRRVFAFKRELKNEHTLLT 523
              |.|...|:.::.|.|:.:|....|. |.|.   |::|.:|....::...||.|........:|
Zfish   359 EKNAKAKALQEERLAVRNFFKTLSDLRGKERS---LQHGEYVGLSNSKSSLAFLRVWDQSKRFIT 420

  Fly   524 IVNVSNRTELVDIADFIEQPNRLSVLVAGVDSQHRVGDRLKAETIELAPNEGLVI 578
            .:|..::...:.:. :.:.|....||::...|...:...:..|.::|.|.:.:::
Zfish   421 ALNWGDKPVTMKLT-YRDLPAEAQVLLSTDTSSLALESMVSLEKLQLDPKQAVLL 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-B1	NP_609522.1	AmyAc_maltase	30..500	CDD:200467	91/478 (19%)
Mal-B1	NP_609522.1	trehalose_treC	33..538	CDD:274115	97/513 (19%)
zgc:158423	NP_001073552.1	SLC3A2_N	29..98	CDD:292647	5/25 (20%)
		AmyAc_family	81..391	CDD:298606	90/481 (19%)
		AmyA	99..446	CDD:223443	97/518 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576548
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1384693at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750