DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mal-B1 and Mal-A8

DIOPT Version :9

Sequence 1:	NP_609522.1	Gene:	Mal-B1 / 34597	FlyBaseID:	FBgn0032381	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_610384.1	Gene:	Mal-A8 / 35830	FlyBaseID:	FBgn0033297	Length:	588	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	267/587 - (45%)
Similarity:	377/587 - (64%)	Gaps:	11/587 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVVVKIAFILSVGLVGILAHKHQSKELDAKYNWWQHEVFYQIYPRSFQDSNGDGIGDLQGITSRL 65
            |.::.:..:|.:.:....|.:.||...:...:|||...|||||||||:||:|||||||.||||:|
  Fly     1 MELLSLLTLLLLAIASNEACQVQSSSSETTKDWWQTAQFYQIYPRSFKDSDGDGIGDLNGITSKL 65

  Fly    66 QYFKDTGITSVWLSPIYESPMVDFGYDISNYTNIQPEYGTLEDFDALIAKANELGVKVILDFVPN 130
            :|.||.|:|:.|||||::|||||||||||::.:|||||||||||..||.:|.||.:|::||||||
  Fly    66 EYLKDLGVTAAWLSPIFKSPMVDFGYDISDFFDIQPEYGTLEDFRTLIKRAKELDLKIVLDFVPN 130

  Fly   131 HSSNKHPWFIKSVAREPGYEDFYVWEDG-ILLENGTRVPPNNWLSVFSGSAWMWNDERQQYYLRQ 194
            ||||:..||:|||.||.||||:|||.|| :....|.|.||.|||..|.||||.||:.||||||.|
  Fly   131 HSSNESEWFLKSVKREKGYEDYYVWHDGKVNSTTGKREPPTNWLQYFRGSAWEWNEVRQQYYLHQ 195

  Fly   195 FTYGQPDLNYRNPAVIKAMDDVMLFWLNKGIAGFRIDAIIYIYE-----DAQLRDEPPSGTTDDP 254
            |...|||||||||.|::.|..|:.:|||:|::|||.||:..::|     |.|..||..||.|:|.
  Fly   196 FAVQQPDLNYRNPLVVEQMKRVLRYWLNEGVSGFRCDALPPLFEVVPDSDGQFPDEVVSGATEDK 260

  Fly   255 NNEAYLSHIYTRNQPEDYGLLQHWRQLLDNYTANHDGPLRIMMTEGYASVSQLMEYYEDSNGVQG 319
            .:..||:..|..||||...::..||.:||::.....|...:::.|.|:.....|::| .:...:|
  Fly   261 EDRDYLTTTYIENQPETIDMVYQWRTVLDDHKRIFGGNSSVLLIETYSPAWFTMQFY-GNRSTEG 324

  Fly   320 PQFPFNFDFITELNANSTAADFV-FYISRWLIYMPHGHVANWVMGNHDNPRVASRFGEKSVDAMN 383
            ...||||:.||.:..:..:|..| ..|..||..||.|...|||:||||..|.|||:|::::|.||
  Fly   325 AHLPFNFNLITVMEQSGLSASNVQEAIDLWLKNMPAGRTPNWVLGNHDKRRAASRYGKENIDGMN 389

  Fly   384 MLLMTLPGIGITYNGEELGMTDYRDISWSDTVDQPACEAGIDNYKTISRDPERTPMQWSSDVNAG 448
            ||:|.|||:.:||.|||:|||| .:|||.||||...|.:..:.|:..:|||||||.||:...|||
  Fly   390 MLVMILPGVSVTYQGEEIGMTD-GEISWEDTVDPWGCNSNPNIYEQYTRDPERTPFQWTGGTNAG 453

  Fly   449 FSSADRTWLPVNPNYKELNLRNQQQARRSHYKIYQSLLKLRQ-LPVLKNGSFVPEVVNRRVFAFK 512
            |::...||||:..:|..:|:..:.....||.|||::|:.||: ...|:|||...:.::..:|..:
  Fly   454 FTNGSSTWLPLAADYATINVEKELSDDHSHLKIYKALVALRKSSKTLQNGSTKYQALSEDIFVVQ 518

  Fly   513 RELKNEHTLLTIVNVSNRTELVDIADFIE-QPNRLSVLVAGVDSQHRVGDRLKAETIELAPNEGL 576
            |.|....|::.::|..:..:.||::.|.: :...|.:|:..:||..:.|.|...:.:.|.|:|.|
  Fly   519 RSLTKSATIVLVINFGSVAKTVDLSQFDKSRTESLQLLIRSIDSTKKEGTRYDPKALSLDPSEAL 583

  Fly   577 VI 578
            |:
  Fly   584 VL 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-B1	NP_609522.1	AmyAc_maltase	30..500	CDD:200467	243/477 (51%)
Mal-B1	NP_609522.1	trehalose_treC	33..538	CDD:274115	250/512 (49%)
Mal-A8	NP_610384.1	AmyAc_maltase	30..506	CDD:200467	243/477 (51%)
		trehalose_treC	33..585	CDD:274115	261/553 (47%)
		Malt_amylase_C	487..585	CDD:295440	26/97 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469254
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	1	0.950	-	0.709012	Normalized mean entropy	S2995
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	12	11.750