DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-B1 and Mal-A3

DIOPT Version :9

Sequence 1:	NP_609522.1	Gene:	Mal-B1 / 34597	FlyBaseID:	FBgn0032381	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_476628.2	Gene:	Mal-A3 / 35826	FlyBaseID:	FBgn0002571	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	263/557 - (47%)
Similarity:	360/557 - (64%)	Gaps:	11/557 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 AKYNWWQHEVFYQIYPRSFQDSNGDGIGDLQGITSRLQYFKDTGITSVWLSPIYESPMVDFGYDI 93
            |:..||:...|||||||||:||:|||:|||.|||.:|.|.|:.|||:.|||||:.|||.|||||:
  Fly    19 AEVGWWKTGQFYQIYPRSFKDSDGDGVGDLIGITQQLPYLKEIGITATWLSPIFTSPMADFGYDV 83

  Fly    94 SNYTNIQPEYGTLEDFDALIAKANELGVKVILDFVPNHSSNKHPWFIKSVAREPGYEDFYVWEDG 158
            ::...|.|.:||:|||:||:|:|.||.:|:||||||||:|::..|||:|.|.|..|:|||||..|
  Fly    84 ADLKGIDPIFGTMEDFEALLARAKELDIKIILDFVPNHTSDECDWFIRSAAGEEEYKDFYVWHTG 148

  Fly   159 ILLENGTRVPPNNWLSVFSGSAWMWNDERQQYYLRQFTYGQPDLNYRNPAVIKAMDDVMLFWLNK 223
            .:: ||.|.||.||:|||.||.|.||::||.|||.||...|||||||||.|::||.||:.|||.|
  Fly   149 KVV-NGIRQPPTNWVSVFRGSMWTWNEQRQAYYLHQFHAKQPDLNYRNPKVVEAMKDVLRFWLRK 212

  Fly   224 GIAGFRIDAIIYIYE-----DAQLRDEPPSGTTDDPNNEAYLSHIYTRNQPEDYGLLQHWRQLLD 283
            |..||||||:.::||     |....|||.:....||.:..||.||||.:|||...|:..:|.:::
  Fly   213 GAYGFRIDAVPHVYEIPADADGNWPDEPRNEAVSDPEDYTYLQHIYTTDQPETLELVYAFRDVIE 277

  Fly   284 NYTANHDGPLRIMMTEGYASVSQLMEYYEDSNGVQ-GPQFPFNFDFITELNANSTAADFVFYISR 347
            ...|...|..|:::||.|:.:..||:||  .||.. |.|.||||:.:.:::.:|.|..:...|..
  Fly   278 EIDAELGGDDRVLLTEAYSPLEVLMQYY--GNGTHLGSQIPFNFELLAKISYSSDAYHYSELIHN 340

  Fly   348 WLIYMPHGHVANWVMGNHDNPRVASRFGEKSVDAMNMLLMTLPGIGITYNGEELGMTDYRDISWS 412
            ||..||.|.|||||.||||..|:.||.|...:||.||:::.|||:.:||.|||:||||.. |||.
  Fly   341 WLDNMPEGQVANWVFGNHDQSRIGSRLGADRIDACNMIILGLPGVSVTYQGEEMGMTDVW-ISWE 404

  Fly   413 DTVDQPACEAGIDNYKTISRDPERTPMQWSSDVNAGFSSADRTWLPVNPNYKELNLRNQQQARRS 477
            ||||..||::....::.::|||.|||.|||.:||||||:|..|||||..|||.:|::.::....|
  Fly   405 DTVDPQACQSNEQEFERLTRDPVRTPFQWSDEVNAGFSNASVTWLPVASNYKLVNVKKERGIALS 469

  Fly   478 HYKIYQSLLKLRQLPVLKNGSFVPEVVNRRVFAFKRELKNEHTLLTIVNVSNRTELVDI-ADFIE 541
            |..:|:.|..||..|.||.|......:...|.||||.|....:.:|::|:::..|.::: :.|..
  Fly   470 HLNVYKQLRALRDEPTLKQGDVSVTAIGPNVLAFKRSLAGYKSYITLININDDVESINLDSVFTS 534

  Fly   542 QPNRLSVLVAGVDSQHRVGDRLKAETIELAPNEGLVI 578
            ...:|..:|....|..|..|...|.::.|.|.|.:|:
  Fly   535 ITTQLQYVVVNDKSVRRKNDLTFANSVLLLPKEAVVL 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-B1	NP_609522.1	AmyAc_maltase	30..500	CDD:200467	242/475 (51%)
Mal-B1	NP_609522.1	trehalose_treC	33..538	CDD:274115	251/511 (49%)
Mal-A3	NP_476628.2	AmyAc_maltase	22..490	CDD:200467	241/471 (51%)
Mal-A3	NP_476628.2	Alpha-amylase	46..400	CDD:278554	182/356 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469258
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	11	10.800