DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-B1 and Mal-A2

DIOPT Version :9

Sequence 1:	NP_609522.1	Gene:	Mal-B1 / 34597	FlyBaseID:	FBgn0032381	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_476625.2	Gene:	Mal-A2 / 35825	FlyBaseID:	FBgn0002569	Length:	567	Species:	Drosophila melanogaster

Alignment Length:	580	Identity:	268/580 - (46%)
Similarity:	359/580 - (61%)	Gaps:	34/580 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VGLVGILAHKHQSKELDAKYNWWQHEVFYQIYPRSFQDSNGDGIGDLQGITSRLQYFKDTGITSV 76
            :||..:|... .::|..|..:||::...|||||||||||:|||||||:||||||.|.|:.|||:.
  Fly     7 LGLAALLLIS-TTQEGTADIDWWENASLYQIYPRSFQDSDGDGIGDLKGITSRLGYLKEIGITAT 70

  Fly    77 WLSPIYESPMVDFGYDISNYTNIQPEYGTLEDFDALIAKANELGVKVILDFVPNHSSNKHPWFIK 141
            |||||:.|||.||||||||:.:|.|.:|||||||.||.:|..||||:||||||||||:::.||.|
  Fly    71 WLSPIFTSPMSDFGYDISNFYDIDPIFGTLEDFDDLIVEAKSLGVKIILDFVPNHSSDENVWFEK 135

  Fly   142 SVAREPGYEDFYVWEDGIL-LENGTRVPPNNWLSVFSGSAWMWNDERQQYYLRQFTYGQPDLNYR 205
            ||.||.||:|||||:||.| .|.|.|.||:||:|||||..|.||::||||:|.||...|||||:.
  Fly   136 SVNREDGYDDFYVWDDGKLNEETGARDPPSNWVSVFSGPMWTWNEKRQQYFLHQFQVKQPDLNFT 200

  Fly   206 NPAVIKAMDDVMLFWLNKGIAGFRIDAIIYIYE----DAQLRDEPPSGTTDDPNNEAYLSHIYTR 266
            ||.|.:.|.||:.|||::|:.||||||:.:|||    |....|||.||...|||...|..||||:
  Fly   201 NPMVREHMLDVLKFWLDRGVDGFRIDAVPHIYEHRNADGSYPDEPVSGWGSDPNAYDYHDHIYTK 265

  Fly   267 NQPEDYGLLQHWRQLLDNYTANHDGPLRIMMTEGYASVSQLMEYYEDSNGVQGPQFPFNFDFITE 331
            :||....|:..||:.||||.|.:.|..|:::.|.|:||..|..|:.:|.. ||.|.|.||. :..
  Fly   266 DQPATVDLMYEWREFLDNYRAQNGGDSRVLLAEAYSSVETLSAYFGNSTH-QGTQLPMNFQ-LMY 328

  Fly   332 LNANSTAADFVFYISRWLIYMPHGH-VANWVMGNHDNPRVASRFGEKSVDAMNMLLMTLPGIGIT 395
            |:..|||.|.|..|..|:..|...| .||||:||||..|||.|.|...||.:|:::..|||..:|
  Fly   329 LSGYSTAKDVVGSIDYWMNTMWKEHQTANWVVGNHDTNRVADRMGAHKVDLLNVIVNALPGASVT 393

  Fly   396 YNGEELGMTDYRDISWSDTVDQPACEAGIDNYKTISRDPERTPMQWSSDVNAGFSSADRTWLPVN 460
            |.|||:||::. |:..:.    .:||         .||.|||||||::..||.||..:.||||::
  Fly   394 YYGEEIGMSNV-DVECTG----DSCE---------DRDGERTPMQWTAGKNADFSDGESTWLPLS 444

  Fly   461 PNYKELNLRNQQQARRSHYKIYQSLLKLRQ----LPVLKNGSFVPEVVNRRVFAFKRELKNEHTL 521
            |.|:..|::.::...||...|::.|.:|:.    |...::|.|..|.|..:|....|..|.....
  Fly   445 PEYQRYNVQTERGVSRSSLNIFKGLQELKSSSAFLAFKEDGGFSYEAVTEQVLQIIRTNKISEEY 509

  Fly   522 LTIVNVSNRTELVD-IADFIEQPNRLSVLVAGVDSQHRVGDRLK-AETIELAPNEGLVIQ 579
            ..:||:.|..|::| :|     |.....::|...|.|..|.:.. ::.|.|.|.|.:|::
  Fly   510 RILVNMGNGMEILDGLA-----PKTYEYVLATAYSTHYSGQKADLSQRIILMPYEAVVLR 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-B1	NP_609522.1	AmyAc_maltase	30..500	CDD:200467	241/479 (50%)
Mal-B1	NP_609522.1	trehalose_treC	33..538	CDD:274115	252/515 (49%)
Mal-A2	NP_476625.2	AmyAc_maltase	24..484	CDD:200467	240/475 (51%)
Mal-A2	NP_476625.2	Alpha-amylase	50..405	CDD:278554	194/357 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469259
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	11	10.800