DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-B1 and Mal-B2

DIOPT Version :9

Sequence 1:	NP_609522.1	Gene:	Mal-B1 / 34597	FlyBaseID:	FBgn0032381	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_001188791.2	Gene:	Mal-B2 / 34598	FlyBaseID:	FBgn0032382	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	345/550 - (62%)
Similarity:	438/550 - (79%)	Gaps:	1/550 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 NWWQHEVFYQIYPRSFQDSNGDGIGDLQGITSRLQYFKDTGITSVWLSPIYESPMVDFGYDISNY 96
            :||.|.||||||||||:||||||||||:||||:|:|..|||||:.|||||::|||:|||||||:|
  Fly    33 DWWPHTVFYQIYPRSFKDSNGDGIGDLKGITSKLRYLADTGITATWLSPIFQSPMIDFGYDISDY 97

  Fly    97 TNIQPEYGTLEDFDALIAKANELGVKVILDFVPNHSSNKHPWFIKSVAREPGYEDFYVWEDGILL 161
            ..|||||||::||:.||..|.|||:||:|||||||||::|.||.||.||||||||||||.|||:.
  Fly    98 KAIQPEYGTMQDFEELIDTAFELGIKVVLDFVPNHSSDQHEWFKKSAAREPGYEDFYVWHDGIVQ 162

  Fly   162 ENGTRVPPNNWLSVFSGSAWMWNDERQQYYLRQFTYGQPDLNYRNPAVIKAMDDVMLFWLNKGIA 226
            |||||||||||.|||.||||.|::.|:||||.|||..|||||||||.|::|||||:|||||||:|
  Fly   163 ENGTRVPPNNWPSVFYGSAWEWHEGREQYYLHQFTKEQPDLNYRNPKVVQAMDDVLLFWLNKGVA 227

  Fly   227 GFRIDAIIYIYEDAQLRDEPPSGTTDDPNNEAYLSHIYTRNQPEDYGLLQHWRQLLDNYTANH-D 290
            ||||||:.:::||..|:|||.||.|.|..:..|..|||:|:.||...::.|||||||:::|.| :
  Fly   228 GFRIDAVNHLFEDESLKDEPLSGKTTDSLSYDYTKHIYSRDLPEVLEMIHHWRQLLDDFSAKHPE 292

  Fly   291 GPLRIMMTEGYASVSQLMEYYEDSNGVQGPQFPFNFDFITELNANSTAADFVFYISRWLIYMPHG 355
            .|.||||||.||.::||.:||||||||:|...||||.|||::..:|.|.|:|:.:.:||||||.|
  Fly   293 RPTRIMMTEAYAGLTQLADYYEDSNGVRGSHLPFNFHFITDVKGDSDARDYVYNVEKWLIYMPRG 357

  Fly   356 HVANWVMGNHDNPRVASRFGEKSVDAMNMLLMTLPGIGITYNGEELGMTDYRDISWSDTVDQPAC 420
            |.||||||||||||||||||..|||||||||:||||:.:|||||||||.|||::||.:|||.||.
  Fly   358 HAANWVMGNHDNPRVASRFGPASVDAMNMLLLTLPGVAVTYNGEELGMVDYRELSWEETVDPPAR 422

  Fly   421 EAGIDNYKTISRDPERTPMQWSSDVNAGFSSADRTWLPVNPNYKELNLRNQQQARRSHYKIYQSL 485
            ..|...|:.:||||.|||.||:::.|||||:|.:|||||:|||.||||..|:.|.||||::|:.|
  Fly   423 NVGEKLYQEVSRDPVRTPFQWNNETNAGFSTAAKTWLPVHPNYLELNLEAQKVANRSHYQVYKDL 487

  Fly   486 LKLRQLPVLKNGSFVPEVVNRRVFAFKRELKNEHTLLTIVNVSNRTELVDIADFIEQPNRLSVLV 550
            |:||:..:::.|.|..|.:.|.||||||...|..:::|::|||::.:|||:::|:.||.:|.|.|
  Fly   488 LELRKSAIMRVGRFNIEPLTRWVFAFKRSYPNFESIITVINVSDKEQLVDLSEFLSQPKKLVVEV 552

  Fly   551 AGVDSQHRVGDRLKAETIELAPNEGLVIQL 580
            :||||:::.|..|.|..:.||..||||.:|
  Fly   553 SGVDSKYQPGQSLAASALLLAAREGLVCRL 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-B1	NP_609522.1	AmyAc_maltase	30..500	CDD:200467	308/468 (66%)
Mal-B1	NP_609522.1	trehalose_treC	33..538	CDD:274115	325/505 (64%)
Mal-B2	NP_001188791.2	AmyAc_maltase	33..502	CDD:200467	308/468 (66%)
Mal-B2	NP_001188791.2	Malt_amylase_C	510..>541	CDD:351862	14/30 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469247
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	1	1.000	-	-		H37289
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	1	0.950	-	0.709012	Normalized mean entropy	S2995
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	12	11.850