DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-B1 and AGBE

DIOPT Version :9

Sequence 1:	NP_609522.1	Gene:	Mal-B1 / 34597	FlyBaseID:	FBgn0032381	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_788342.1	Gene:	AGBE / 326264	FlyBaseID:	FBgn0053138	Length:	685	Species:	Drosophila melanogaster

Alignment Length:	466	Identity:	102/466 - (21%)
Similarity:	156/466 - (33%)	Gaps:	143/466 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VGILAHKHQSKELD-----AKY------------NWWQH---EVFYQIY---------PRSFQ-- 48
            :.|:...|..:.||     |||            |:.|:   ...|:.|         |:|.:
  Fly   121 IKIIIRNHSGQLLDRLSPWAKYVVQPPKSANQGVNYKQYVWEPPSYERYQRQHPGPPRPKSLRIY 185

  Fly    49 ------DSNGDGIGDLQGITSRL-QYFKDTGITSVWLSPIYE-SPMVDFGYDISNYTNIQPEYGT 105
                  .|....:|.......|: ...|..|...:.:..|.| :....|||.::::......||.
  Fly   186 ECHVGIASQEPRVGSYDEFADRIVPRIKRQGYNCIQVMAIMEHAYYASFGYQVTSFYAASSRYGN 250

  Fly   106 LEDFDALIAKANELGVKVILDFVPNHSSNKHPWFIKSVAREPGYEDFYVWEDG---ILLENGTRV 167
            .|....:|..|:..|:.|:||.|.:|:|       |:|  :.|...|    ||   ....:|.|.
  Fly   251 PEQLKRMIDVAHSHGLFVLLDVVHSHAS-------KNV--QDGLNQF----DGTNSCFFHDGARG 302

  Fly   168 PPNNWLS-------------VFSGSAWMWNDERQQYYLRQFTY-GQPDLNYRNPAVIKAM--DDV 216
            ..:.|.|             :.|...| |:||   |....:.: |...:.|.:..:.:..  |..
  Fly   303 EHSLWDSRLFNYVEYEVLRFLLSNLRW-WHDE---YNFDGYRFDGVTSMLYHSRGIGEGFSGDYN 363

  Fly   217 MLFWLN--------KGIAG---FRIDA-IIYIYEDAQLRDEPPSG--TTDDPNNEAYLSHIY--- 264
            ..|.||        .|:|.   ..||: ||.|.||.       ||  |...|.:|..:...|
  Fly   364 EYFGLNVDTDALNYLGLANHLLHTIDSRIITIAEDV-------SGMPTLCRPVSEGGIGFDYRLG 421

  Fly   265 ----------TRNQPE---DYGLLQH------WRQLLDNYTANHDGPL--------RIMMTEGYA 302
                      .:.|.:   |.|.|.|      |.:....|..:||..|        .:|..|.|.
  Fly   422 MAIPDKWIELLKEQSDDEWDMGNLVHTLTNRRWMENTVAYAESHDQALVGDKTIAFWLMDKEMYT 486

  Fly   303 SVSQLMEYYEDSNGV--QGPQFPFNFDFITELNANSTAADFV---FYISRWLIYMPHGHVANWVM 362
            .:|.|    .||:.:  :|.........||.........:|:   |....||.: |.       :
  Fly   487 HMSTL----SDSSVIIDRGLALHKMIRLITHALGGEAYLNFMGNEFGHPEWLDF-PR-------V 539

  Fly   363 GNHDNPRVASR 373
            ||:|:...|.|
  Fly   540 GNNDSYHYARR 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-B1	NP_609522.1	AmyAc_maltase	30..500	CDD:200467	97/446 (22%)
Mal-B1	NP_609522.1	trehalose_treC	33..538	CDD:274115	94/431 (22%)
AGBE	NP_788342.1	GlgB	52..682	CDD:223373	102/466 (22%)
		E_set_GBE_euk_N	62..161	CDD:199884	9/39 (23%)
		AmyAc_bac_euk_BE	167..570	CDD:200460	92/420 (22%)
		Alpha-amylase_C	588..683	CDD:280898
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443596
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930