DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-B1 and Slc3a1

DIOPT Version :9

Sequence 1:	NP_609522.1	Gene:	Mal-B1 / 34597	FlyBaseID:	FBgn0032381	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_058912.1	Gene:	Slc3a1 / 29484	RGDID:	3709	Length:	683	Species:	Rattus norvegicus

Alignment Length:	591	Identity:	208/591 - (35%)
Similarity:	328/591 - (55%)	Gaps:	44/591 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVVVKIAFILSVGLVGILAHKHQSKELDAKYNWWQHEVFYQIYPRSFQDSNGDGIGDLQGITSRL 65
            :.||.:..::...:..|:.   ..|.||    |||....||||||||:||:.||.|||:||..:|
  Rat    89 LTVVSVFLLIGATIAIIII---SPKCLD----WWQAGPMYQIYPRSFKDSDKDGNGDLKGIQEKL 146

  Fly    66 QYFKDTGITSVWLSPIYESPMVDFGYDISNYTNIQPEYGTLEDFDALIAKANELGVKVILDFVPN 130
            .|.....|.::|::..|:||:.||.|.:.::..|.|.:||::||:.|:|..::.|:|:|:||:||
  Rat   147 DYITALNIKTIWITSFYKSPLKDFRYAVEDFKEIDPIFGTMKDFENLVAAVHDKGLKLIIDFIPN 211

  Fly   131 HSSNKHPWFIKSVAREPGYEDFYVWEDGILLENGTRVPPNNWLSVFSGSAWMWNDERQQYYLRQF 195
            |:|:|||||..|..|...|.|:|:|.: ....||...||||||||:..|:|.:::||:|.|..||
  Rat   212 HTSDKHPWFQSSRTRSGKYTDYYIWHN-CTHANGVTTPPNNWLSVYGNSSWQFDEERKQCYFHQF 275

  Fly   196 TYGQPDLNYRNPAVIKAMDDVMLFWLNKGIAGFRIDAIIYIYEDAQLRDEPPSGTTDDPN----- 255
            ...|||||:|||||.:.:.:::.|||:||:.||..||:.::.|...||:|....|:..|:
  Rat   276 LKEQPDLNFRNPAVQEEIKEIIKFWLSKGVDGFSFDAVKFLLEAKDLRNEIQVNTSQIPDTVTRY 340

  Fly   256 NEAYLSHIYTRNQPEDYGLLQHWRQLLDNYTANHDGPLRIMMTEGYA-SVSQLMEYYEDSNGVQG 319
            :|.|  |.:|..|...:.|::.:||.::.: :...|..|.|.||..| |..:.|.|| ..:.:|.
  Rat   341 SELY--HDFTTTQVGMHDLVRDFRQTMNQF-SREPGRYRFMGTEVSAESTERTMVYY-GLSFIQE 401

  Fly   320 PQFPFNFDFITELNANSTAADFVFY--ISRWLIYMPHGHVANWVMGNHDNPRVASRFGEKSVDAM 382
            ..|||| .::..|:   |.:....|  |:.|:..||.|...||::|..:..|:.||.|.:.|:||
  Rat   402 ADFPFN-KYLATLD---TLSGHTVYEAITSWMENMPEGKWPNWMIGGPETSRLTSRVGSEYVNAM 462

  Fly   383 NMLLMTLPGIGITYNGEELGMTDYRDISWSDTVDQPACEAGIDNYKTISRDPERTPMQWSSDVNA 447
            ||||.||||..|||.|||:||.|....:.::..|..|..:             ::||||.:..||
  Rat   463 NMLLFTLPGTPITYYGEEIGMGDISITNLNERYDTNALLS-------------KSPMQWDNSSNA 514

  Fly   448 GFSSADRTWLPVNPNYKELNLRNQQQARRSHYKIYQ--SLLKLRQLPVLKNGSFVPEVVNRRVFA 510
            ||:.|:.||||.|.:|..:|:..|:....|..::||  |||..|:| :|..|.|.....:.....
  Rat   515 GFTEANHTWLPTNSDYHTVNVDVQKTQPSSALRLYQDLSLLHAREL-LLSRGWFCLLRDDNHSVV 578

  Fly   511 FKRELKN-EHTLLTIVNVSNRTELVDIADFI-EQPNRLSVLVAGVDSQHRVGDRLKAETIELAPN 573
            :.|||.. :...|.::|....:.::::.:.| :.|.:|.:.::  .:....|..:....:.|...
  Rat   579 YTRELDGIDKVFLVVLNFGESSTVLNLQETISDVPTKLRIRLS--TNPASKGSDVDTHAVSLEKG 641

  Fly   574 EGLVIQ 579
            |||:::
  Rat   642 EGLILE 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-B1	NP_609522.1	AmyAc_maltase	30..500	CDD:200467	188/479 (39%)
Mal-B1	NP_609522.1	trehalose_treC	33..538	CDD:274115	194/515 (38%)
Slc3a1	NP_058912.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
Slc3a1	NP_058912.1	AmyAc_SLC3A1	113..566	CDD:200494	188/479 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337365
Domainoid	1	1.000	288	1.000	Domainoid score	I1508
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37289
Inparanoid	1	1.050	379	1.000	Inparanoid score	I1996
OMA	1	1.010	-	-		QHG53234
OrthoDB	1	1.010	-	-		D1384693at2759
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		otm44438
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	O	PTHR10357
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X202
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810