DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-B1 and mal1

DIOPT Version :9

Sequence 1:	NP_609522.1	Gene:	Mal-B1 / 34597	FlyBaseID:	FBgn0032381	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_595063.1	Gene:	mal1 / 2539976	PomBaseID:	SPBC1683.07	Length:	579	Species:	Schizosaccharomyces pombe

Alignment Length:	550	Identity:	192/550 - (34%)
Similarity:	274/550 - (49%)	Gaps:	79/550 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 KYNWWQHEVFYQIYPRSFQDSNGDGIGDLQGITSRLQYFKDTGITSVWLSPIYESPMVDFGYDIS 94
            |.|||:....|||||.||:||||||.|||:||.|::.|.|...:.|:||.|||.||:.|.|||:|
pombe    10 KPNWWRETSVYQIYPASFKDSNGDGFGDLEGIISKVDYLKALNVESIWLCPIYPSPLKDMGYDVS 74

  Fly    95 NYTNIQPEYGTLEDFDALIAKANELGVKVILDFVPNHSSNKHPWFIKSVAREPG-YEDFYVWEDG 158
            :|..|...||||||.|.|:...:|..:|:::|.|.||:|::|.||.:|.:.:.. ..|:|.|:..
pombe    75 DYKQIDSRYGTLEDLDRLMKALHERDMKLVMDLVLNHTSDQHEWFKESRSSKTNPKRDWYFWKPA 139

  Fly   159 ILLENGTRVPPNNWLSVFSGSAWMWNDERQQYYLRQFTYGQPDLNYRNPAVIKAMDDVMLFWLNK 223
            ...|.|.|:|||||.|.|..|||.|::..|:|||..::.||||||:..|.|.:|:.|::.|||::
pombe   140 RYNEKGERLPPNNWRSYFDTSAWEWDEATQEYYLHLWSVGQPDLNWETPKVREAVHDILRFWLDR 204

  Fly   224 GIAGFRIDAIIYIYEDAQLRDEPPSGTTDDPNNEAYLSHIYTRNQPEDYGLLQHWRQLLDNYTAN 288
            |:.|||:|||..|.:|.:..|.|   .||| ..|..|::.|..|.|..:..|.....:|..|.|
pombe   205 GVDGFRLDAINMISKDQRFLDAP---ITDD-RYEYQLAYQYYANGPRIHEYLNGIGNILTEYDA- 264

  Fly   289 HDGPLRIMMTEGYASVSQLMEYYEDSN------GVQGPQFP--FNFDFI-TELNANS-------- 336
                         .||.: |.|..|:|      |....:..  |.|||: .:|:.|.
pombe   265 -------------FSVGE-MPYVLDTNEILHVVGADRRELTMIFQFDFVDLDLDPNQHKYIEGSW 315

  Fly   337 TAADFVFYISRWLIYMPHGHVANW---VMGNHDNPRVASRFGEKS--VDAMNMLLMTL-----PG 391
            ..:|....:.:|...:..|  ..|   .:.|||..|..||:...|  ..|.:..||.|     .|
pombe   316 ELSDLKKSLKKWQSALLSG--GGWNASFIENHDQTRTVSRYLSDSPKYRAYSSKLMALFIIFQSG 378

  Fly   392 IGITYNGEELGMT---------DYRDIS----W----SDTVDQPACEAGIDNYKTISRDPERTPM 439
            ....:.|:||.:.         :|.|:.    |    |....|...|..:|.....:||..||||
pombe   379 TPFVFQGQELALANIPRDWPIDEYLDVETQNFWKLFMSGNPSQEEIEKTMDIVNKRARDNGRTPM 443

  Fly   440 QWSSDVNAGFSSAD-RTWLPVNPNYKELNLRNQQQARRSHYKIYQSLLKLRQLPVLKN----GSF 499
            .|.|..|.||:.|. :.|:.|..:|||.|..||.....|.|..:...|:||:  .||:    |||
pombe   444 HWDSSPNGGFTKAGVKPWMRVTNDYKEWNAANQVNDPESPYTFWSKALELRK--ELKDAVVYGSF 506

  Fly   500 VPEVVNRR---VFAFKRELKNEHTLLTIVN 526
              |:::..   :.||.|| .:.:.|:.::|
pombe   507 --ELISEEDPSIVAFVRE-SSTYKLIILLN 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-B1	NP_609522.1	AmyAc_maltase	30..500	CDD:200467	184/519 (35%)
Mal-B1	NP_609522.1	trehalose_treC	33..538	CDD:274115	189/546 (35%)
mal1	NP_595063.1	trehalose_treC	13..579	CDD:274115	189/546 (35%)
		AmyAc_SI_OligoGlu_DGase	15..496	CDD:200472	176/503 (35%)
		Malt_amylase_C	504..576	CDD:295440	9/32 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	218	1.000	Domainoid score	I560
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I649
OMA	1	1.010	-	-		QHG53234
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		otm46985
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	O	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
TreeFam	0	0.000	Not matched by this tool.
	11	10.870