DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-B1 and Mal-A6

DIOPT Version :9

Sequence 1:	NP_609522.1	Gene:	Mal-B1 / 34597	FlyBaseID:	FBgn0032381	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_724679.2	Gene:	Mal-A6 / 246565	FlyBaseID:	FBgn0050360	Length:	601	Species:	Drosophila melanogaster

Alignment Length:	600	Identity:	287/600 - (47%)
Similarity:	377/600 - (62%)	Gaps:	30/600 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VKIAFILSVGL---VGILAH-----KHQSKELDAKYNWWQHEVFYQIYPRSFQDSNGDGIGDLQG 60
            |.||.||.:|:   :|..|.     :..:...|...:|||...||||||||::||:|||||||||
  Fly     6 VLIAAILVLGIHCALGSAAAVDLDLERATTAADTTRDWWQVAQFYQIYPRSYKDSDGDGIGDLQG 70

  Fly    61 ITSRLQYFKDTGITSVWLSPIYESPMVDFGYDISNYTNIQPEYGTLEDFDALIAKANELGVKVIL 125
            |.|:|.|.|:.|:|:.||||||.|||.|||||||::.:||||||||.|||.|||:|.:..:|:||
  Fly    71 IISKLDYLKEIGVTATWLSPIYSSPMADFGYDISDFFDIQPEYGTLADFDELIAEAKKRNIKIIL 135

  Fly   126 DFVPNHSSNKHPWFIKSVAREPGYEDFYVWEDG-ILLENGTRVPPNNWLSVFSGSAWMWNDERQQ 189
            ||||||||:::.||.|||.||.||||:|:|.|| :....|.|.||:|||..|.||||.|||||||
  Fly   136 DFVPNHSSDENVWFQKSVKREKGYEDYYMWHDGYVNATTGKREPPSNWLQAFRGSAWEWNDERQQ 200

  Fly   190 YYLRQFTYGQPDLNYRNPAVIKAMDDVMLFWLNKGIAGFRIDAIIYIYE-----DAQLRDEPPSG 249
            |||.||...|||||||||||:..|..|:.:||::|:||||:||:.:.:|     |.:..|||.||
  Fly   201 YYLHQFAVKQPDLNYRNPAVVAQMKRVLTYWLDRGVAGFRMDAVPWCFEVLPDADGRYPDEPLSG 265

  Fly   250 TTDDPNNEAYLSHIYTRNQPEDYGLLQHWRQLLDNYTANHDGPLRIMMTEGYASVSQLMEYYEDS 314
            .||||::.:||.||||::..|...::..||.|||:|...|.|..|::|.|.|:.:..:|::| .:
  Fly   266 YTDDPDDSSYLKHIYTQDLRETVEMVFQWRTLLDDYQRIHGGDTRVIMVETYSGLDYVMQFY-GN 329

  Fly   315 NGVQGPQFPFNFDFI---------TELNANSTAADFVFYISRWLIYMPHGHVANWVMGNHDNPRV 370
            ...:|.|.||||.||         |:|||..    ||..||.||..||.|..|||||||||..||
  Fly   330 RTTKGAQMPFNFQFIIGGNGDKNNTQLNATG----FVKIISSWLSQMPAGQTANWVMGNHDQRRV 390

  Fly   371 ASRFGEKSVDAMNMLLMTLPGIGITYNGEELGMTDYRDISWSDTVDQPACEAGIDNYKTISRDPE 435
            .||:||..:|.||||.|.|||:.|||.||||||||. ||||.|:.|..||.:..|.|:..:|||.
  Fly   391 GSRYGENRIDLMNMLQMFLPGVSITYQGEELGMTDL-DISWEDSRDPAACNSNSDIYEQFTRDPA 454

  Fly   436 RTPMQWSSDVNAGFSSADRTWLPVNPNYKELNLRNQQQARRSHYKIYQSLLKLRQLPVLKNGSFV 500
            |||.|||.:.|||||:...||||:||||..:|.:.:.....||..:|:.|:.||:...|:.|:..
  Fly   455 RTPFQWSDEANAGFSTNATTWLPINPNYVTVNAKAENSTSPSHLSLYKQLVDLRKSKTLQFGATR 519

  Fly   501 PEVVNRRVFAFKRELKNEHTLLTIVNV-SNRTELVDIADFIEQPNRLSVLVAGVDSQHRVGDRLK 564
            ...|...|.|.:|.|..|.:.:.:.|| ......:|:|..|.......:.:....::..|||.:.
  Fly   520 YANVGDNVVAIRRYLSGEPSYVLVANVLDTSVSGIDVASAIYATGSYKIKLLNPQAKATVGDSVT 584

  Fly   565 AETIELAPNEGLVIQ 579
            ...:.|.|...|:::
  Fly   585 LSNLTLEPYAALILE 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-B1	NP_609522.1	AmyAc_maltase	30..500	CDD:200467	261/484 (54%)
Mal-B1	NP_609522.1	trehalose_treC	33..538	CDD:274115	270/520 (52%)
Mal-A6	NP_724679.2	AmyAc_maltase	40..516	CDD:200467	260/481 (54%)
Mal-A6	NP_724679.2	trehalose_treC	43..599	CDD:274115	278/561 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469255
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	11	10.800