DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment esc and EED

DIOPT Version :9

Sequence 1:	NP_477431.1	Gene:	esc / 34595	FlyBaseID:	FBgn0000588	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_001294936.1	Gene:	EED / 8726	HGNCID:	3188	Length:	466	Species:	Homo sapiens

Alignment Length:	447	Identity:	217/447 - (48%)
Similarity:	299/447 - (66%)	Gaps:	33/447 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSDKVKNGNEPEESEESCGDESASYTTNSTTSRSKSPSSSTRSKRR---GRRSTKSKPKSRAAY 62
            :|||  :|.|.....:|:  |::.|..:.:.|.|..:|:::..:..|   |:...||| |.:.::
Human    23 LSSD--ENSNPDLSGDEN--DDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSK-KCKYSF 82

  Fly    63 KYDTHVKENHGANIFGVAFNTLLGKDEPQVFATAGSNRVTVYECPRQGGMQLLHCYADPDPDEVF 127
            |....:||:|...:|||.||....:.:|.||||.||||||:|||..||.::||..|.|.|.||.|
Human    83 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENF 147

  Fly   128 YTCAWSYDLKTSSPLLAAAGYRGVIRVIDVEQNEAVGNYIGHGQAINELKFHPHKLQLLLSGSKD 192
            |||||:||..||.||||.||.||:||:|:....:.:.:|:|||.|||||||||....||||.|||
Human   148 YTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKD 212

  Fly   193 HAIRLWNIQSHVCIAILGGVEGHRDEVLSIDFNMRGDRIVSSGMDHSLKLWCLNTPEFHHKIELS 257
            ||:||||||:...:||.||||||||||||.|:::.|::|:|.|||||||||.:|:....:.|:.|
Human   213 HALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKES 277

  Fly   258 NTFSQEKSTLPFPTVTKHFPDFSTRDIHRNYVDCVQWFGNFVLSK-------------------- 302
            ..::..|:..||.:...||||||||||||||||||:|.|:.:|||
Human   278 YDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSGRAILHSHQQCMRDPVSPN 342

  Fly   303 -----SCENAIVCWKPGQLHQSFEQVKPSDSSCTIIAEFEYDECEIWFVRFGFNPWQKVIALGNQ 362
                 ||||||||||||::....:::|||:|:.||:..|:|.:|:||::||..:.|||::|||||
Human   343 LRQHLSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQ 407

  Fly   363 QGKVYVWELDPSDPEGAHMTTLHNSRSVATVRQIAFSRDASVLVYVCDDATVWRWNR 419
            .||:|||:|:..||..|..|||.:.:..|.:||.:||||:|:|:.|||||::|||:|
Human   408 VGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDR 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esc	NP_477431.1	WD40	<67..425	CDD:225201	199/378 (53%)
		WD40	72..418	CDD:295369	195/370 (53%)
		WD40 repeat	76..122	CDD:293791	25/45 (56%)
		WD40 repeat	128..168	CDD:293791	21/39 (54%)
		WD40 repeat	173..210	CDD:293791	25/36 (69%)
		WD40 repeat	220..282	CDD:293791	27/61 (44%)
		WD40 repeat	289..337	CDD:293791	27/72 (38%)
		WD40 repeat	345..386	CDD:293791	22/40 (55%)
		WD40 repeat	393..417	CDD:293791	14/23 (61%)
EED	NP_001294936.1	WD40 repeat	96..140	CDD:293791	24/43 (56%)
		WD40 repeat	148..188	CDD:293791	21/39 (54%)
		WD40	150..463	CDD:421866	163/312 (52%)
		WD40 repeat	193..230	CDD:293791	25/36 (69%)
		WD40 repeat	240..302	CDD:293791	27/61 (44%)
		WD40 repeat	309..382	CDD:293791	27/72 (38%)
		WD40 repeat	390..430	CDD:293791	21/39 (54%)
		WD40 repeat	438..462	CDD:293791	14/23 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141257
Domainoid	1	1.000	236	1.000	Domainoid score	I2346
eggNOG	1	0.900	-	-		E1_KOG1034
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2814
Inparanoid	1	1.050	488	1.000	Inparanoid score	I1435
Isobase	1	0.950	-	0	Normalized mean entropy	S1215
OMA	1	1.010	-	-		QHG59795
OrthoDB	1	1.010	-	-		D1191277at2759
OrthoFinder	1	1.000	-	-		FOG0005723
OrthoInspector	1	1.000	-	-		otm41215
orthoMCL	1	0.900	-	-		OOG6_102885
Panther	1	1.100	-	-	O	PTHR10253
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2640
SonicParanoid	1	1.000	-	-		X4715
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750