Protein Alignment esc and mes-6

DIOPT Version :10

• Sequence 1: NP_477431.1
• Gene: esc / 34595
• FlyBaseID: FBgn0000588
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_001370414.1
• Gene: mes-6 / 177657
• WormBaseID: WBGene00003224
• Length: 459
• Species: Caenorhabditis elegans
• Alignment Length: 440
• Identity: 117/440 - (26%)
• Similarity: 185/440 - (42%)
• Gaps: 80/440 - (18%)

  Fly    50 RSTKSKPKSRAAYKYDTHVKENHGANIFGVAFNTLLGKDEPQVFATAGSNRVTVYECPRQ-GGMQ 113
            |||:...|  ..:.....:.|:....|:|.|||...|.||.|..||.|.:.:.:|..|.. ..::
 Worm    17 RSTEDYGK--RPFVLTAKLLEDQKKAIYGCAFNQYAGIDEEQAVATVGGSFLHMYSVPIDINNIE 79

  Fly   114 L-LHCYADPDP------DEVFYTCAWSYDL----KTSSPL-LAAAGYRGVIRVIDVEQNEAVGNY 166
            | ..|....|.      :|..:|..|.||.    ...:|. :...|..|.|.|||....:.....
 Worm    80 LQWSCNFPTDKSSKVEREESLFTVTWCYDTYEAENDRNPFKVVTGGTLGHIYVIDYVSRKLSNRL 144

  Fly   167 IGHGQAINELKFHPHKLQLLLSGSKDHAIRLWNIQSHVCIAILGGVEGHRDEVLSIDFNMRGDRI 231
            ...|..||:::..|....|::..|.|.:||:.:|::..|:.::||:|.|...:||:|::..||.|
 Worm   145 RSVGWEINDIRTCPANSNLIVCASSDQSIRIHHIRNEACLIVIGGLECHAGTILSVDWSTDGDFI 209

  Fly   232 VSSGMDHSLKLWCLNTPEFHHKIELS---------NTFSQ-------EKSTLPFPTVTKHFPD-- 278
            :|.|.||.|..|.|:..:....:|.:         |..:|       .|.|:....|:::.||
 Worm   210 LSCGFDHQLMEWDLSVKQVKEHLERACKALHQDKINVLTQSQDIPYVSKGTMRKSAVSRNIPDKE 274

  Fly   279 --------------------------FSTRDIHRNYVDCVQWF--GNFVLSKSC--ENAIVCWKP 313
                                      .|| |:|.:||||:::.  .|:.|||.|  |.||..|:.
 Worm   275 EDQLLELHRELIPRPSCLLPIYTPSSVST-DMHSDYVDCIRFLIGTNYALSKGCGNEKAIHFWRF 338

  Fly   314 G--------QLHQSFEQVKPSDSSCTI-IAEFEYDECEIWFVRFGFNPWQKVIALGNQQGKVYVW 369
            |        ::|.:..:.|    |||. ...........||::|..:|.::.:..|...|.|..:
 Worm   339 GPPKGEVENRIHGNVLRPK----SCTTKFRTMNVPSGSAWFIKFAVDPRRRWLVCGGAGGSVMFF 399

  Fly   370 ELDPSDPEGAHMTTLHNSRSVATVRQIAFSRDASVLVYVCDDATVWRWNR 419
            :|..::......|....||   ||||.:||.....||.|.|:..|.|::|
 Worm   400 DLRNNEETNPTHTCSVGSR---TVRQASFSTCGRFLVLVTDEGFVCRFDR 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
esc	NP_477431.1	WD40	72..420	CDD:441893	112/418 (27%)
		WD40 repeat	76..122	CDD:293791	16/47 (34%)
		WD40 repeat	128..168	CDD:293791	11/44 (25%)
		WD40 repeat	173..210	CDD:293791	10/36 (28%)
		WD40 repeat	220..282	CDD:293791	22/105 (21%)
		WD40 repeat	289..337	CDD:293791	18/60 (30%)
		WD40 repeat	345..386	CDD:293791	8/40 (20%)
		WD40 repeat	393..417	CDD:293791	10/23 (43%)
mes-6	NP_001370414.1	WD40	120..433	CDD:475233	82/320 (26%)
		WD40 repeat	152..192	CDD:293791	11/39 (28%)
		WD40 repeat	197..233	CDD:293791	13/35 (37%)
		WD40 repeat	245..280	CDD:293791	7/34 (21%)
		WD40 repeat	310..367	CDD:293791	18/60 (30%)
		WD40 repeat	375..415	CDD:293791	8/39 (21%)
		WD40 repeat	420..444	CDD:293791	10/23 (43%)