Protein Alignment Pde1c and Pde1c

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: NP_112340.1
• Gene: Pde1c / 81742
• RGDID: 68332
• Length: 768
• Species: Rattus norvegicus
• Alignment Length: 752
• Identity: 282/752 - (37%)
• Similarity: 389/752 - (51%)
• Gaps: 219/752 - (29%)

  Fly   421 ESLPPVDTPDALNKAAGRIRSLLRRMDHETVAYEDMQRNLHYAARVLEAVFIDESREGCNGNCKN 485
            :.||.:|:|:||.|.:.|:|||:::::....:..|:::||.|||.|||:|:|||:|
  Rat    86 DELPQLDSPEALVKTSFRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETR--------- 141

  Fly   486 LNCSRHSHGRDDQQQDNNNSNRSCSLQEASPGGAGAGVTPGADNQDSIESRTKGVSQAPQTHSGP 550
                                                                             
  Rat   142 ----------------------------------------------------------------- 141

  Fly   551 TGPPSNTSSETIAQPAPKLQPALETVRESVMEESPSKDPGDKGPPPPASTSTLTSQTTTSSSATA 615
                                                                             
  Rat   142 ----------------------------------------------------------------- 141

  Fly   616 EPSAKAAESQAGSAGSSGSCSNPAAVHRQRRLRTPTWARSMSTNKTRLADEDDELSEVQPDAVPP 680
                                                          ||.|.:||||::|.||||.
  Rat   142 ----------------------------------------------RLLDTEDELSDIQSDAVPS 160

  Fly   681 EVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRRVSSSALTAFPPDVVRLLKN 745
            |||:||||||||||....|:|||||:|:|:.||::|||||:|||||.|:....::||.|:..||:
  Rat   161 EVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKD 225

  Fly   746 LDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNN 810
            :|.|:||||:|.||:....:|::.|||..||..|.:|||....|.:|:..:|.||.:::|||||.
  Rat   226 VDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNL 290

  Fly   811 LHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRA 875
            :||.||.||:||.|..||:.||||:|||||.:.:|.:|||||||||||||:.:.|:.|:|||||:
  Rat   291 MHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRS 355

  Fly   876 VLENHHASASFRLLRED-EYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQE 939
            ||||||.||::|||:|| |.|||.:||::::||.|.||||||:.|||:.||||:|||:..|...|
  Rat   356 VLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE 420

  Fly   940 ATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVA 1004
            | |:|.|.|||:||..|||||||.|.:||||||.||||||||||.|.||||||||||||.:|:||
  Rat   421 A-IEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVA 484

  Fly  1005 ESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPS 1069
            :||:.||||||||:..|::||.|.|::|:.. ..|:.....:..::.||..:|..
  Rat   485 QSQVGFIDFIVEPTFTVLTDMTEKIVSPLID-ETSQTGGTGQRRSSLNSINSSDA---------- 538

  Fly  1070 MDKPRDHRTEAKTTAAECLA--RKSVTGTTASKFNIPKPWLTCLVENKRIWK------EQAVKDA 1126
                  .|:..|::.:|..|  ..||.......|.  ..|...:..|:..|:      |:|.|:|
  Rat   539 ------KRSGVKSSGSEGSAPINNSVIPVDYKSFK--ATWTEVVQINRERWRAKVPKEEKAKKEA 595

  Fly  1127 EARA-LATAAEEAAAAAAAEAEE---SKPETETADGE 1159
            |.:| ||...::....|.::||:   ||.|.:|: ||
  Rat   596 EEKARLAAEEKQKEMEAKSQAEQGTTSKAEKKTS-GE 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	40/59 (68%)
		PDEase_I	807..1027	CDD:459723	146/220 (66%)
Pde1c	NP_112340.1	PDEase_I_N	142..202	CDD:462497	0/59 (0%)
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P14100	183..206		0/22 (0%)
		PDEase_I	287..515	CDD:459723	102/227 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	513..557		31/43 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	584..719		79/134 (59%)
		PTZ00121	<603..>695	CDD:173412	64/91 (70%)