DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde1c and pde9aa

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_009302928.1	Gene:	pde9aa / 799942	ZFINID:	ZDB-GENE-130920-1	Length:	509	Species:	Danio rerio

Alignment Length:	409	Identity:	109/409 - (26%)
Similarity:	189/409 - (46%)	Gaps:	52/409 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   661 TRLADEDDELSEVQPDAVPPEVREW----LASTFTRQMATSRRKSD-------EKPKFRSVAHAI 714
            ::|||:::....|.........|.:    |.:..|.::|...::.:       |..|.||....:
Zfish    82 SQLADKEELFQNVLTQVAEQFSRAFKINELKTEVTNRLAMLEKRVELEGMKVVEIEKCRSDIKKL 146

  Fly   715 RAGIFVDRMYRRVSSSAL------------TAFP-----PDVVRLLKN--LDDWTFDVFALTEAA 760
            |     :.|..|.:||.|            .::|     .|.|..||.  .|.|.::
Zfish   147 R-----EEMASRNNSSFLEDNKKLTPRRDVPSYPKYHLSQDTVEALKQPLFDVWQWE-------- 198

  Fly   761 SGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLC 825
            |.:::..:.: :::..|.:..|.|.|..|:.:|..:.:.|  ..||:||..|...|.|.::..:.
Zfish   199 SNEMLSCLEH-MYHDLGLVKDFNINPITLKRWLLCIHDNY--RNNPFHNFRHCFCVTQMMYSMIY 260

  Fly   826 NTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLR 890
            ..||....|.::|...:.||:.||.:|.|..|.:.:.:.:|.|:.|||.:.|||||.:.:|::..
Zfish   261 LCGLQEKFTQVDILILMTAAVCHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQIFS 325

  Fly   891 EDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQ-KVLSLVL-H 953
            :.:.||.:....|.|:::|...|.::|.|||..|.:.|.:.:|.:...:...::. ..|.:|| .
Zfish   326 QPDCNIFASFDPEAFKQIRQGTITLILATDMARHGEIMDSFKQKVDSFDYNNEEHVTCLKMVLIK 390

  Fly   954 CCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPS 1018
            |||||:..:...|...|...||||:|.|.|.||..|||.:|..||.......:||.||.|::.|.
Zfish   391 CCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKAEGLPVAPFMDREKVTKPTAQIGFIKFVLIPM 455

  Fly  1019 ----MGVMSDMLELILAPI 1033
                |.:...:.|:::.|:
Zfish   456 FETVMKLFPQIEEVMVQPL 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	10/66 (15%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	72/224 (32%)
pde9aa	XP_009302928.1	PDEase_I	242..472	CDD:278654	73/229 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920