DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde1c and pde4b

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_031756141.1	Gene:	pde4b / 780324	XenbaseID:	XB-GENE-963512	Length:	733	Species:	Xenopus tropicalis

Alignment Length:	751	Identity:	186/751 - (24%)
Similarity:	312/751 - (41%)	Gaps:	181/751 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 MQPSSPNATNYLADNIQISSANLSQTEMVVGRDSADYTAMHSINVGVGNSFLRGDTDIP------ 398
            |:.|....|....||:|      :.||:.:.:..:.|.....|::..|..|..|...:|
Frog     1 MKKSRSVMTVTAEDNVQ------NFTEVCLSKSYSSYGYNMGIDLWKGKRFCSGTLQLPPLHHRQ 59

  Fly   399 ------QESGHSFET-----PSNMSFTAGQWDTESLPPVDTPDALNKAAGRIRSLLRRMDHETVA 452
                  .:..|...|     |..::.|..:.|:..:....||       ||     ..:||
Frog    60 MRRAKTPDYIHRPTTLPLLLPPKIAVTPVEKDSFDVENGPTP-------GR-----SPLDH---- 108

  Fly   453 YEDMQRNLHYAARVLEAVFIDESREGCNGNCKNLNCSRHSHGRD------DQQQDNNNSNRSCSL 511
                                 ::..| :|...:.|.:.|:..|:      |...|.:....|.:.
Frog   109 ---------------------QASPG-SGLVLHTNFTSHNQRRESFLYRSDSDYDLSPKTMSRNS 151

  Fly   512 QEAS-PGGAGAGVTPGADNQDSIESRTKGVSQAPQTHSGPTGPPSNTSSETIAQPAPKLQPALET 575
            ..|| ..|....|||.|....|:.|.....:.....|..|     |..|....||        :.
Frog   152 SAASEQHGDDLIVTPFAQVLASLRSVRNNFTVLTNVHGAP-----NKRSPMTTQP--------QI 203

  Fly   576 VRESVMEESPSKDPGDKGPPPPASTSTL-----------TSQTTTSSSATAEPSAKAAESQAGSA 629
            .|.::.|:|..|          .:..||           |.||..|.|
Frog   204 SRVNLQEDSYQK----------IAMDTLEELDWCLDQLETIQTYRSVS----------------- 241

  Fly   630 GSSGSCSNPAAVHRQRRLRTPTWARSMSTNKTR--LADEDDELSEVQPDAVPPEVREWLASTFTR 692
                                     .|::||.:  |..|...|||:....  .:|.|:::|||..
Frog   242 -------------------------EMASNKFKRMLNRELTHLSEMSRSG--NQVSEYISSTFLD 279

  Fly   693 -----QMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRRVSSSAL-----------TAFPPDVVR 741
                 ::.:..:|..||.|.:.:...| :|:     .:.:.||:|           |.:...:.:
Frog   280 KQNDVEIPSPTQKDREKKKKQQLMTQI-SGV-----KKLMHSSSLNNTSMSRFGVKTEYEDMLSK 338

  Fly   742 LLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNP 806
            .|::|:.|..::|.:...:..:.:..:.|.:|.....:..|||....|..:...:|:.| .....
Frog   339 ELEDLNKWGLNIFKVASYSCNRPLTCIMYAIFQERDLLKTFKIPADTLITYTMTLEDHY-HSDVA 402

  Fly   807 YHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLY 871
            |||:|||.||.|:.|..|....|....|||||.|::.||.:||.:|.|.:|.|.:.:.||.||:|
Frog   403 YHNSLHAADVTQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMY 467

  Fly   872 NDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLT 936
            ||.:||||||.:..|:||:|:..:|..:|::::.:.||.:||:|||.|||:.|...:..::.::.
Frog   468 NDESVLENHHLAVGFKLLQEEHCDIFQNLTKKQRQSLRKMVIDMVLATDMSKHMSLLADLKTMVE 532

  Fly   937 LQEAT----------IDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLP 991
            .::.|          .|:.:||..::||.|:|:|.|...::.:||..::||||:|||.|:|.|:.
Frog   533 TKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGME 597

  Fly   992 FSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLE 1027
            .||:||::...|.:||:.|||:||.|.....:|:::
Frog   598 ISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQ 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	15/60 (25%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	92/228 (40%)
pde4b	XP_031756141.1	PDE4_UCR	164..279	CDD:407935	36/181 (20%)
pde4b	XP_031756141.1	PDEase_I	403..644	CDD:395177	92/231 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920