DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde1c and pde2a

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_031751996.1	Gene:	pde2a / 780063	XenbaseID:	XB-GENE-5945995	Length:	964	Species:	Xenopus tropicalis

Alignment Length:	317	Identity:	95/317 - (29%)
Similarity:	158/317 - (49%)	Gaps:	30/317 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   772 LFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRN-PYHNNLHAVDVMQTIHYCLC---NTGLMNW 832
            :|...|.::.:||....|..|...|::|   ||: ||||.:||..|.   |:|..   |..|:|:
Frog   638 MFEDMGFVNNYKIDRTTLIRFCLMVKKG---YRDPPYHNWMHAFSVS---HFCYLLFKNLELVNY 696

  Fly   833 LTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLY-NDRAVLENHHASASFRLLREDEYNI 896
            |..:||||..::.|.||.:|.||.|:|.|.|.|..|.|| ::.:|:|.||.:.:..:|.....||
Frog   697 LEYIEIFALFVSCLCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNSQGCNI 761

  Fly   897 LSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQK------VLSLVLHCC 955
            |...||::::.:..|:.:::|.||:.:|   ::..::|..:.:...|.|.      ::.|::...
Frog   762 LEQFSRKDYQRMLDLMRDIILATDLAHH---LRIFKELTRMSQDGFDPQNKHHHYLLICLLMTSS 823

  Fly   956 DISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMG 1020
            |:|...|.|....:...|:.:|||.||||||.:|...|.:.||....:.|.||.|::.|..|...
Frog   824 DLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPSEMMDREKAYIPELQISFMEHIAMPIYN 888

  Fly  1021 VMSDML--ELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRD 1075
            ::.|:.  ...|......|:.| .|.|.|:.|...       :|::.....:|:..|
Frog   889 LLKDLFPRSAELYERVATNREK-WTRVSHKFTIRG-------LPSNNSLDFLDEEYD 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	74/228 (32%)
pde2a	XP_031751996.1	GAF	255..401	CDD:214500
		GAF	423..574	CDD:214500
		PDEase_I	671..904	CDD:395177	75/238 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010