Protein Alignment Pde1c and Pde10a

DIOPT Version :9

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: XP_038945075.1
• Gene: Pde10a / 63885
• RGDID: 68434
• Length: 1075
• Species: Rattus norvegicus
• Alignment Length: 1207
• Identity: 240/1207 - (19%)
• Similarity: 401/1207 - (33%)
• Gaps: 376/1207 - (31%)

  Fly    36 SSPVSSIAIPAARVPRHRL-----RHADRDQKRDHSSDGLVSSG-ELRDEFMGIDAQPRRESLNS 94
            :||...:| |..:.|...:     |...|.:.|..::.|..:.| .|..|.:|...:
  Rat     2 ASPEERLA-PRPQAPLPEVGDEPGRGQVRLEPRRGAASGRSAVGLSLARELLGCGRE-------- 57

  Fly    95 CEVGSPGTMSSSLGKAGRLNSSRYPSGGAGAIGLSVMGNLVGTTTRKCVLTLDGYSYVIVAST-- 157
             |:.:|..:|.||..||..:    |:||.||:.:...|. .|....:....| .:|..:.:|:
  Rat    58 -ELAAPPPLSRSLSPAGHAS----PAGGPGALSVLSAGG-CGWVAARAPWAL-AFSSPVPSSSFS 115

  Fly   158 -------------------------PESLPSKRDEASGGPGSSGGTSGAATSSSSSGGGAASGAA 197
                                     ||.||.:...|:.|.|..||      ...:.|||....|.
  Rat   116 SSWYFWPPPPLPPPPLVPSSSAFHLPERLPRREGAAAAGGGGGGG------GGDAGGGGGGQEAD 174

  Fly   198 SGSVGPASGTATGTGSASGGAGG-----VSTPAQEAASPTVSELSGSGSNATINGQVARHGSLTI 257
            ..||.|.|...:|.|| |||:||     :|...|....|     :.||.......::..|..
  Rat   175 PLSVPPGSSHRSGGGS-SGGSGGRWRLFLSPAIQGLLLP-----ARSGPRPPPPPRLPLHPG--- 230

  Fly   258 IRRTNSRNFTQFDGQLASPSSTACSSTAPGIGFAQTPLSEPLAERLSFRASGGSNGSASAGD--- 319
            ..|.:|..|....|        .|....||         .....|..:|..|.:...|:|..
  Rat   231 AHRADSLGFPGAGG--------GCPGLGPG---------SAAGGRTPWRPRGTALPLATAWPLLF 278

  Fly   320 SRSSNQGPSNSGPAASAAVKMQPS--SPNATN-----YLADNIQISSANLSQTEMVVGRDSADYT 377
            ......||||:   ||...::...  ||:.|:     ||:.:.|:....:|::   |..::.:..
  Rat   279 GSDMEDGPSNN---ASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSES---VSAETVEKW 337

  Fly   378 AMHSINVGVGNSFLRGDTDIPQESGHSFETPSNMSFTAGQWDTESLPPVDTPDALNKAAGRIRSL 442
            .....|..       .|...|:|.....:|  ||.....:.::.....:||..
  Rat   338 LKRKNNKA-------EDEPSPKEVSRYQDT--NMQGVVYELNSYIEQRLDTGG------------ 381

  Fly   443 LRRMDHETVAYEDMQRNLHYAARV--LEAVFIDESREGCNGNCKNLNCSRHSHGRDDQQQDNNNS 505
                |:..:.|| :...:..|.:.  ....|:        |.|.|
  Rat   382 ----DNHLLLYE-LSSIIRIATKADGFALYFL--------GECNN-------------------- 413

  Fly   506 NRSCSLQEASPGGAGAGVTPGADNQDSIESRTKGVSQAPQTHSGPTGPPSNTSSETIAQPAPKLQ 570
                ||...:|.|...|                      |....|.||  .|...||:....|.:
  Rat   414 ----SLCVFTPPGMKEG----------------------QPRLIPAGP--ITQGTTISAYVAKSR 450

  Fly   571 PALETVRESVMEESPSKDPGDKGPPPPASTSTLTSQTTTSSSATAEPSAKAAESQAGSA------ 629
            ..|  :.|.::        ||:..|    ..|.....|...|....|...|.....|..
  Rat   451 KTL--LVEDIL--------GDERFP----RGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHW 501

  Fly   630 GSSGSCSNPAAVHRQRRLRTPTWARSMSTNKTRLA---DEDDELSEVQPDAVPPEVREWLA---- 687
            |....|.:    |::.......|| |::.::.::.   .:..||::...|.........:|
  Rat   502 GKEAFCLS----HQEVATANLAWA-SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSL 561

  Fly   688 ----STFTRQMATSRR----------------------KSDEKPKF---RSVAHAIRAGI----- 718
                ..:.:.:..:.|                      :.:.||.|   :.:..:|..||
  Rat   562 LEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVA 626

  Fly   719 -----------FVDRMYRR------------------VSSSALTAFPPDVVRLLKNL-------- 746
                       :.|..:.|                  ||..::..    ||:::..:
  Rat   627 RTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIG----VVQMVNKISGSAFSKT 687

  Fly   747 DDWTFDVFAL-----------------TEAASGQVVKYVAY------------------------ 770
            |:..|.:||:                 :|......::.::|
  Rat   688 DENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMHFNLPARICRD 752

  Fly   771 -ELFNRYGSIHKFK-IAPGILEAFLHR-------VEEGYCRY---------RNPYHNNLHAVDVM 817
             |||  :..|..|: :.|||....:||       ..|..||:         |.||||..|||
  Rat   753 IELF--HFDIGPFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAV--- 812

  Fly   818 QTIHYCLC-----NTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVL 877
             |:.:|:.     |.||   .||||....|:|.|.||.:|.|.:|::........|.||: .:.:
  Rat   813 -TVAHCMYAILQNNNGL---FTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYS-TSTM 872

  Fly   878 ENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATI 942
            |.||.|.:..:|:.:.:||.|.||..|:.::..::.:.::.||:..:|...|.:.::.......:
  Rat   873 EQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNL 937

  Fly   943 DKQ----KVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRN-NTL 1002
            ..|    :|:.|::..||:....|.|.|.......:..||:.:||..|:||:...|:.||: ...
  Rat   938 HNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDE 1002

  Fly  1003 VAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKS 1039
            |.:.|:.|.:.:..|....::.    ||.|..|:.|:
  Rat  1003 VPQGQLGFYNAVAIPCYTTLTQ----ILPPTEPLLKA 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	11/104 (11%)
		PDEase_I	807..1026	CDD:278654	63/228 (28%)
Pde10a	XP_038945075.1	GAF	382..525	CDD:396252	38/218 (17%)
		GAF	558..713	CDD:214500	17/158 (11%)
		PDEase_I	805..1037	CDD:395177	68/243 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920