DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde1c and pde8b

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_009293455.1	Gene:	pde8b / 571011	ZFINID:	ZDB-GENE-091117-3	Length:	874	Species:	Danio rerio

Alignment Length:	954	Identity:	198/954 - (20%)
Similarity:	338/954 - (35%)	Gaps:	289/954 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 AQEAASPTVSELSGSGSNATINGQVARHGSLTII----------RRTNSRNFTQFD--GQLASPS 277
            :.|:.||..:.....|:..|::|...:..:...|          .||||....:.:  ||:.:.:
Zfish    20 SDESNSPHQTTTISQGTATTLHGLFIKTDAADTIPSVIAYQTRHTRTNSHRERRENSGGQMCTEA 84

  Fly   278 STACSSTAPGIGFAQTPLS------EPL-------------------AERLSFRASGGSNGSASA 317
            .|..|.|:..:..|:..|.      ||:                   .||.:||.:......::.
Zfish    85 ETQTSCTSVKVSGAEDRLGPMRLSHEPIQVLLVFAKEDSQSDAFWWACERAAFRCNIARTPESAL 149

  Fly   318 G------------DSRSSNQGPSNSGPAASAAVKM---------QPSSPN--------------- 346
            .            |.|......:.:......|.|:         .|.:|:
Zfish   150 ECFLDKHHEIVIIDGRHPRYFEAEAICRMIRATKLSEHTVILAVMPQTPSDQEEPSVLPLLSAGF 214

  Fly   347 ATNYLADNIQISSANLSQTEMVVGRDSAD---------YTAMHSINVGVGNS------------- 389
            :..|| :|..:|:......::..|...|.         :||:......|..|
Zfish   215 SRRYL-ENSSVSACYNELIQLEHGEVRAQFKLRACNAVFTALEQCQEAVEISSEDHVIQYVNPAF 278

  Fly   390 -----FLRGD------TDIPQESGHS---FETPSNMSFTAGQWDTESLPPVDTPDALNK------ 434
                 :.||:      |::|:...:|   .:|.:.......:|.........:.|::.:
Zfish   279 EKMMGYHRGELIGKELTELPRSDKNSADLLDTINTCIKKGKEWQGIYFSRRKSGDSIQQYVKITP 343

  Fly   435 ---AAGRIRSL--LRRMDHETVAYEDMQRNLHYAARVLEAVFIDESREGCNGNCKNLNCSRHSHG 494
               ..|:||..  ::|      .|.|..|.:|..::          .|.|        |..||..
Zfish   344 VVGQGGKIRHFVSIKR------PYSDNHRQVHKLSK----------EEKC--------CGEHSQS 384

  Fly   495 RDDQQQDNNNSNRSCSLQEASPGGAGAGVTPGADNQDSIESRTKGVSQAPQTHSGPTGPPSNTSS 559
            ..:..:..:....|..::                   ||.|.:   |.||...:......:...|
Zfish   385 ECNSLRHKDRRKESVDVR-------------------SISSHS---SDAPSLQNRRYSSMARIHS 427

  Fly   560 ETIAQPAPKLQPALETVRESVMEESPSKDPGDKGPPPPASTSTLTSQTTTSSSATAEPSAKAAES 624
            .||..|..|:...:...:||                              |....||...:..|
Zfish   428 MTIEAPITKVINIINAAQES------------------------------SPVTVAEALDRVLE- 461

  Fly   625 QAGSAGSSGSCSNPAAVHRQRRLRTPTWARSMSTNKTRLADEDDELSEVQPDAVPPEVREWLAST 689
                            :.|...|.:|           :||.::|:          |...:.:...
Zfish   462 ----------------ILRTTELYSP-----------QLASKEDD----------PHTNDLVGGL 489

  Fly   690 FTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRRVSSS------ALTAFPPDVVRLLKNLDD 748
            .:..:   ||.|..:            .||.....:.:|.|      .|...||.:..||...:.
Zfish   490 MSDGL---RRLSGNE------------YIFSKSALQNMSQSQLGVPVPLNDIPPSIAELLNEEEQ 539

  Fly   749 WTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHA 813
            |.|::..|..|...:.:.|:..::|:.:|.......:...|..:|..:|..| ...|.|||:.||
Zfish   540 WEFNILELEAATHKRPLSYLGLKIFSAFGVCEFLNCSESTLRLWLQVIETNY-HSSNSYHNSTHA 603

  Fly   814 VDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLE 878
            .||:....|.|....:...|..|:..|:||||.:||.:|.|.||:|...:|||.|:||||.||||
Zfish   604 ADVLHATAYFLRKERVKASLDQLDEVAALLAATVHDVDHPGRTNSFLCNAGSELAILYNDTAVLE 668

  Fly   879 NHHASASFRL-LREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQ-----------MKAM 931
            :|||:.:|:| :|:.:.||..::.|.:||.||..:|:|||.|:||.||:.           |.|:
Zfish   669 SHHAALAFQLTVRDSKCNIFKNMERTQFRTLRQAIIDMVLATEMTRHFEHVNKFVNSINKPMSAI 733

  Fly   932 RQLLTLQE-------ATI-----DKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDL 984
            .:..:..|       |:|     ::..:..:::.|.|:::|.:...:...|...:.||:|.|.|.
Zfish   734 EETSSNSEGSDCEGQASIRNSPENRLLIKRMLIKCADVANPCRPLELCIEWAGRISEEYFAQTDE 798

  Fly   985 EKELGLP-FSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLE 1027
            ||..||| ..|:.|||...:.:|||.|||:.:       :||.:
Zfish   799 EKRQGLPVVMPVFDRNTCSIPKSQISFIDYFI-------TDMFD 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	7/55 (13%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	87/243 (36%)
pde8b	XP_009293455.1	PDE8	1..47	CDD:285793	6/26 (23%)
		TIM_phosphate_binding	<143..>212	CDD:304361	6/68 (9%)
		PAS_9	260..357	CDD:290162	13/96 (14%)
		PAS	264..357	CDD:238075	12/92 (13%)
		PDEase_I	597..850	CDD:278654	88/246 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920