DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde1c and pde1a

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_005167982.1	Gene:	pde1a / 564465	ZFINID:	ZDB-GENE-090831-2	Length:	611	Species:	Danio rerio

Alignment Length:	508	Identity:	246/508 - (48%)
Similarity:	334/508 - (65%)	Gaps:	35/508 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   662 RLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRR 726
            ||.|.:||||::|.|:||.|||:||||||||:|...||:.:|||:|||:.||::|||||:|||||
Zfish    81 RLLDTEDELSDIQADSVPMEVRDWLASTFTRKMGVVRRRPEEKPRFRSIVHAVQAGIFVERMYRR 145

  Fly   727 VSSSALTAFPPDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEA 791
            .|:.|...:||.|:..||::|.|:||||.|.||:|...:|::.|||..||..|.:|:|....|.:
Zfish   146 TSNMAGLTYPPSVITALKDVDKWSFDVFKLQEASSDHALKFLVYELLTRYDLISRFRIPVSSLVS 210

  Fly   792 FLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTT 856
            |:..:|.||.::||||||.:||.||.||.||.:.:||:|:|||:|||.|.:.||.:||:||||||
Zfish   211 FVEALEIGYSKHRNPYHNLIHAADVTQTAHYLMLHTGVMHWLTELEILAMVFAAAIHDFEHTGTT 275

  Fly   857 NNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDM 921
            ||||:.:.||.|:|||||:||||||.||::||::|||.|||.:||::::||||.||||||:.|||
Zfish   276 NNFHIQTRSEVAILYNDRSVLENHHVSAAYRLMQEDEMNILVNLSKDDWRELRTLVIEMVMSTDM 340

  Fly   922 TNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEK 986
            :.||||:|.||..|...|. |||.|.|||:||..|||||||.|.:|:|||..|:||||||||.|.
Zfish   341 SCHFQQIKTMRNSLQQPEG-IDKAKALSLMLHAADISHPAKGWKLHYRWTQALMEEFFRQGDKEA 404

  Fly   987 ELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTA 1051
            ||||||||||||..|::|:|||.||||||||:..|:.|..|.|::|           |:|....:
Zfish   405 ELGLPFSPLCDRKATMIAQSQIGFIDFIVEPTFSVLVDTTEKIISP-----------LIEEAVKS 458

  Fly  1052 NSTTNSAIVIPNS-GITPSMDKPRDHRTE----AKTTAAEC-LARKSVTGTTASKFNIPKPWLTC 1110
            .....|::....| .:..|:.:..|..:.    ..|..:.| :.:|.|           :..|:.
Zfish   459 GGVRRSSLTGRGSAAVVESVQRHSDRGSNDECGGSTDYSLCGIDQKHV-----------RHLLSE 512

  Fly  1111 LVE-NKRIWKEQAVKDAEARALATAAEEAAAAAAAEAEESKPETETADGEQSE 1162
            ::: ||..|||.:|::     ||....|..:....|...|...|.:.:...||
Zfish   513 IIQNNKERWKELSVQE-----LANKQHERMSDLQEEPMRSTQLTLSQENHDSE 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	35/55 (64%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	141/218 (65%)
pde1a	XP_005167982.1	PDEase_I_N	85..141	CDD:285672	35/55 (64%)
pde1a	XP_005167982.1	PDEase_I	226..442	CDD:278654	140/216 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	300	1.000	Domainoid score	I1397
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21043
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1218
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D439875at33208
OrthoFinder	1	1.000	-	-		FOG0001902
OrthoInspector	1	1.000	-	-		otm25613
orthoMCL	1	0.900	-	-		OOG6_100946
Panther	1	1.100	-	-	LDO	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.970